Results 61 to 70 of about 380,200 (294)

A prospective evaluation of the predictive value of faecal calprotectin in quiescent Crohn’s disease [PDF]

, 2014
Background: The faecal calprotectin (FC) test is a non-invasive marker for gastrointestinal inflammation. Aim: To determine whether higher FC levels in individuals with quiescent Crohn’s disease are associated with clinical relapse over the ensuing 12 ...
Allan J. Morris, Beltrán, Best, Boschetti, Centre for Evidence-based purchasing, Cosnes, Costa, D'Haens, D'Incà, Daniel R. Gaya, De Suray, Ferreiro, García-Sánchez, Gisbert, Gisbert, Graham D. Naismith, Guidi, Hanaway, Jack W. Winter, Joanna I. Munro, Jones, Kallel, Karen Rankin, Kennedy, Laharie, Lamb, Langhorst, Lemann, Louis, Lyn A. Smith, Manz, Mao, Molander, Naismith, Pardi, Primas, Roseth, Roseth, Roseth, Sarah J.E. Barry, Saverymuttu, Schoepfer, Schoepfer, Sipponen, Sipponen, Susan Laird, Sutherland, Tibble, Tibble, Van Rheenen, Wagner   +50 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Meta-analysis of gene expression disease signatures in colonic biopsy tissue from patients with ulcerative colitis

Scientific Reports, 2021
Publicly available ulcerative colitis (UC) gene expression datasets from observational studies and clinical trials include inherently heterogeneous disease characteristics and methodology. We used meta-analysis to identify a robust UC gene signature from
Bryan Linggi, Vipul Jairath, Guangyong Zou, Lisa M. Shackelton, Dermot P. B. McGovern, Azucena Salas, Bram Verstockt, Mark S. Silverberg, Shadi Nayeri, Brian G. Feagan, Niels Vande Casteele   +10 more
doaj   +1 more source

Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models [PDF]

, 2015
Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments.
Azevedo, Vasco, Bermudez Humaran, Luis G., Chatel, Jean Marc, de Moreno, Maria Alejandra, del Carmen, Silvina Andrea, Langella, Philippe, Leblanc, Jean Guy Joseph, Miyoshi, Anderson   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles: A focus on inflammatory bowel disease

Clinical and Translational Medicine
Background Mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) have emerged as key regulators of intercellular communication, orchestrating essential biological processes by delivering bioactive cargoes to target cells.
Laura Clua‐Ferré, Roger Suau, Irene Vañó‐Segarra, Iris Ginés, Carolina Serena, Josep Manyé   +5 more
doaj   +1 more source

Correlation Between Low Bone Density and Disease Activity in Patients with Ulcerative Colitis [PDF]

, 2015
BACKGROUND Different clinical and epidemiological studies using dual-energy X-ray absorptiometry have shown an increased prevalence of low bone mineral density in patients with inflammatory bowel diseases.
Aghaei, M., Amiriani, T., Besharat, M., Besharat, S., Faghani, M., Joshaghani, H., Mirkarimi, H.S., Pourramezan, Z., Roshandel, G.   +8 more
core  

NOD2 and inflammation: current insights [PDF]

, 2018
The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory ...
Cucchiara, Salvatore, Negroni, Anna, Pierdomenico, Maria, Stronati, Laura   +3 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

SARS-CoV-2 Omicron BA.1 Variant Infection of Human Colon Epithelial Cells

Viruses
The Omicron variant of SARS-CoV-2, characterized by multiple subvariants including BA.1, XBB.1.5, EG.5, and JN.1, became the predominant strain in early 2022.
Avan Antia, David M. Alvarado, Qiru Zeng, Luis A. Casorla-Perez, Deanna L. Davis, Naomi M. Sonnek, Matthew A. Ciorba, Siyuan Ding   +7 more
doaj   +1 more source