Results 41 to 50 of about 3,225,863 (285)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Utility of serological markers in inflammatory bowel diseases: Gadget or magic? [PDF]

, 2008
The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Anti–Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely investigated ...
Papp, Mária, Lakatos, Péter László, Norman, G. L., Altorjay, István   +3 more
core  

Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases.

, 2007
Anemia is a common complication of inflammatory bowel diseases. An international working party has formed and developed guidelines for evaluation and treatment of anemia and iron deficiency that should serve practicing gastroenterologists. Within a total
Rampton, D, Travis, Simon, Berstad, A, Hjortswang, Henrik,, Schroeder, O, Stein, J, Van Assche, G, Oldenburg, B, Beglinger, C, Travis, S, Gomollon, F, Dignass, A, Befrits, R, Hjortswang, H, Koutroubakis, I, Gasche, C, Erichsen, K, Kulnigg, S   +17 more
core   +1 more source

Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases [PDF]

, 2014
Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining
Syed Tariq Sadiq, Nibali, L, Luigi Nibali, Henderson, B, Sadiq, ST, Brian Henderson, Donos, N, Nikos Donos   +7 more
core   +2 more sources

Identification of areas of functioning and disability addressed in Inflammatory bowel disease-specific patient reported outcome measures [PDF]

, 2012
Inflammatory Bowel Disease (IBD) is a chronic disabling disease of the gastrointestinal tract. The disease is strongly associated with limited performance of everyday activities and restrictions in work and employment, recreation and relationships to ...
Achleitner, Ulrike
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Mesenteric fat proliferation on magnetic resonance enterography is a predictor of long-term disease complications in crohn’s disease

BMC Gastroenterology
Background Fibrofatty proliferation of mesenteric fat is a common finding on magnetic resonance enterography (MRE) in Crohn’s disease (CD) patients. Mesenteric fat may play a role in inflammation, fibrosis, and stricture formation, but its prognostic ...
Eduard Koifman, Inna Spector Cohen, Rebeca Lopez-Alonso, Dana Ben Hur, Anat Ilivitzki, Matti Waterman   +5 more
doaj   +1 more source

A Replicating Single-Cycle Adenovirus Vaccine Effective against Clostridium difficile

Vaccines, 2020
Clostridium difficile causes nearly 500,000 infections and nearly 30,000 deaths each year in the U.S., which is estimated to cost $4.8 billion. C. difficile infection (CDI) arises from bacteria colonizing the large intestine and releasing two toxins ...
William E. Matchett, Stephanie Anguiano-Zarate, Goda Baddage Rakitha Malewana, Haley Mudrick, Melissa Weldy, Clayton Evert, Alexander Khoruts, Michael Sadowsky, Michael A. Barry   +8 more
doaj   +1 more source

Impact of the first wave of COVID-19 on Crohn’s disease after the end of “zero-COVID” policy in China

Frontiers in Public Health, 2023
BackgroundThe incidence and severity of coronavirus disease 2019 (COVID-19) among Crohn’s disease (CD) patients are unknown in China. This study aimed to clarify the clinical courses and outcomes of CD patients in the first COVID-19 wave after the end of
Wen Hu, Xiao Li, Zelin Yan, Qiuzhi Wang, Jiakai Luo, Qiao Yu, Shuyan Li, Shiyuan Lu, Atiyeh Roozbahani, Ehsan Ghoushi, Yan Chen, Jun Li   +11 more
doaj   +1 more source