Results 31 to 40 of about 380,200 (294)

DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis [PDF]

open access: yes, 2014
Inflammatory bowel diseases (IBD) are emerging globally, indicating that environmental factors may be important in their pathogenesis. Colonic mucosal epigenetic changes, such as DNA methylation, can occur in response to the environment and have been ...
Bronsky, Jiri   +10 more
core   +2 more sources

Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology [PDF]

open access: yes, 2017
Helminth parasites are highly prevalent in many low- and middle-income countries, in which inflammatory bowel disease and other immunopathologies are less frequent than in the developed world.
Fleming, John O.   +2 more
core   +1 more source

Substance P Mediates Proinflammatory Cytokine Release From Mesenteric Adipocytes in Inflammatory Bowel Disease PatientsSummary

open access: yesCellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Substance P (SP) neurokinin-1 receptors (NK-1Rs) are expressed in mesenteric preadipocytes, and SP binding activates proinflammatory signaling in these cells. We evaluated the expression levels of SP (Tac-1), NK-1R (Tacr-1), and NK-2R (
Aristea Sideri   +9 more
doaj   +1 more source

Recent trends in the epidemiology of inflammatory bowel diseases: up or down? [PDF]

open access: yes, 2006
Inflammatory bowel disease (IBD) is traditionally considered to be common in the Western world, and its incidence has sharply increased since the early 1950s.
Lakatos, Péter László
core   +1 more source

Identification of a Novel Substance P–Neurokinin-1 Receptor MicroRNA-221-5p Inflammatory Network in Human Colonic Epithelial CellsSummary

open access: yesCellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Substance P (SP), a neuropeptide member of the tachykinin family, plays a critical role in colitis. MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate gene expression.
Kai Fang   +6 more
doaj   +1 more source

Mesenteric excision surgery or conservative limited resection in Crohn’s disease: study protocol for an international, multicenter, randomized controlled trial

open access: yesTrials, 2020
Background The structures of the mesentery including adipose tissue, nerves, and lymphatics play an important role in the pathogenesis and disease progression of Crohn’s disease (CD).
Yi Li   +9 more
doaj   +1 more source

Utility of serological markers in inflammatory bowel diseases: Gadget or magic? [PDF]

open access: yes, 2007
The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Although anti-Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely ...
Altorjay, István   +3 more
core   +1 more source

Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage [PDF]

open access: yes, 2015
Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission and often serious side effects.
Brun, Paola   +10 more
core   +6 more sources

Carbohydrate Intake in the Etiology of Crohn's Disease and Ulcerative Colitis [PDF]

open access: yes, 2014
Background: Diet may have a role in the etiology of inflammatory bowel disease. In previous studies, the associations between increased intakes of carbohydrates, sugar, starch, and inflammatory bowel disease are inconsistent.
Abraham   +83 more
core   +1 more source

Enteric glia: A new player in inflammatory bowel diseases [PDF]

open access: yes, 2015
In addition to the well-known involvement of macrophages and neutrophils, other cell types have been recently reported to substantially contribute to the onset and progression of inflammatory bowel diseases (IBD).
Capoccia, E   +8 more
core   +1 more source

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