Results 11 to 20 of about 242,877 (255)

DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier InjurySummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Tumor necrosis factor (TNF) superfamily member tumor necrosis factor–like protein 1A (TL1A) has been associated with the susceptibility and severity of inflammatory bowel diseases. However, the function of the tumor necrosis factor–
Yosuke Shimodaira, Shyam K. More, Hussein Hamade, Anna Y. Blackwood, Jay P. Abraham, Lisa S. Thomas, Jordan H. Miller, Dalton T. Stamps, Sofi L. Castanon, Noam Jacob, Connie W.Y. Ha, Suzanne Devkota, David Q. Shih, Stephan R. Targan, Kathrin S. Michelsen   +14 more
doaj   +1 more source

Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome

Genome Medicine, 2022
Background Crohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unaffected controls. However, the impact of inflammation and underlying genetic risk on these microbial profiles and
Jonathan P. Jacobs, Maryam Goudarzi, Venu Lagishetty, Dalin Li, Tytus Mak, Maomeng Tong, Paul Ruegger, Talin Haritunians, Carol Landers, Philip Fleshner, Eric Vasiliauskas, Andrew Ippoliti, Gil Melmed, David Shih, Stephan Targan, James Borneman, Albert J. Fornace, Dermot P. B. McGovern, Jonathan Braun   +18 more
doaj   +1 more source

Development and evaluation of a risk assessment tool to improve clinical triage accuracy for colonoscopic investigations

BMC Cancer, 2018
Background Gastroenterology Departments at hospitals within Australia receive thousands of General Practitioner (GP)-referral letters for gastrointestinal investigations every month. Many of these requests are for colonoscopy. This study aims to evaluate
Anton R. Lord, Lisa A. Simms, Allison Brown, Katherine Hanigan, Krupa Krishnaprasad, Belinda Schouten, Anthony R. Croft, Mark N. Appleyard, Graham L. Radford-Smith   +8 more
doaj   +1 more source

A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and AutophagySummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD).
Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney, Iulia Oancea, Gregor Kijanka, Sumaira Hasnain, Andrew J. Lucke, David P. Fairlie, Michael A. McGuckin, Timothy H. Florin, Jakob Begun   +17 more
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Mesenteric Adipose-derived Stromal Cells From Crohn’s Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis

Cellular and Molecular Gastroenterology and Hepatology, 2018
Mesenteric adipose tissue hyperplasia is a hallmark of Crohn’s disease (CD). Recently, we showed that mesenteric adipose-derived stromal cells (ADSCs) from CD, ulcerative colitis, and control patients synthesize and release adipokines in a disease ...
Jill M. Hoffman, Aristea Sideri, Jonathan J. Ruiz, Dimitris Stavrakis, David Q. Shih, Jerrold R. Turner, Charalabos Pothoulakis, Iordanes Karagiannides   +7 more
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A modern view on the management of patients with ulcerative colitis of mild and moderate severity in outpatient practice

Лечащий Врач, 2022
The article discusses modern approaches to the treatment of ulcerative colitis. It is indicated that for the choice of tactics and treatment algorithm, the extent of the lesion, as well as the severity of the current exacerbation, classified as mild ...
A. M. Kharitidis, O. B. Shchukina
doaj   +1 more source

Internet and WeChat used by patients with Crohn’s disease in China: a multi-center questionnaire survey

BMC Gastroenterology, 2019
Background Currently, WeChat is widely used in disease education for patients with Crohn’s disease (CD) in China. It is beneficial for the patients to actively engage in their disease management.
Qiao Yu, Liyi Xu, Lili Li, Min Zhi, Yubei Gu, Xinying Wang, Hong Guo, Yue Li, Yihong Fan, Bolin Yang, Meng Xue, Minfang Lv, Dingting Xu, Hanyun Zhang, Yan Li, Yongmao Song, Qun Deng, Xiaoxu Huang, Jing Zhong, Wen Hu, Yimiao Zhu, Xiaoying Wang, Jianting Cai, Yan Chen   +23 more
doaj   +1 more source

Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated FibrosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Cathelicidin (LL-37 in human and mCRAMP in mice) represents a family of endogenous antimicrobial peptides with anti-inflammatory effects.
Jun Hwan Yoo, Samantha Ho, Deanna Hoang-Yen Tran, Michelle Cheng, Kyriaki Bakirtzi, Yuzu Kubota, Ryan Ichikawa, Bowei Su, Diana Hoang-Ngoc Tran, Tressia C. Hing, Irene Chang, David Q. Shih, Richard E. Issacson, Richard L. Gallo, Claudio Fiocchi, Charalabos Pothoulakis, Hon Wai Koon   +16 more
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Prevalence and predictors of non-alcoholic liver disease on MRI among patients with Crohn's disease

BMC Gastroenterology, 2022
Background It has been documented that Crohn’s disease (CD) patients were prone to develop non-alcoholic liver fatty liver disease (NAFLD) with less metabolic factors.
Qijin Hong, Jun Shen, Qi Feng, Qing Zheng, Yuqi Qiao   +4 more
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SARS-CoV-2 IgG Antibody Levels in Women with IBD Vaccinated during Pregnancy

Vaccines, 2022
Introduction: Regulatory agencies supported vaccination of pregnant women with SARS-CoV-2 mRNA vaccines, including patients with IBD. No data exist regarding these vaccines in IBD during pregnancy.
Irit Avni Biron, Yair Maayan, Tali Mishael, Eran Hadar, Michal Neeman, Romina Plitman Mayo, Hen Y. Sela, Simcha Yagel, Rosalind Goldenberg, Ami Ben Ya’acov, Sorina Grisaru Granovsky, Jacob E. Ollech, Hadar Edelman-Klapper, Keren Masha Rabinowitz, Maor H. Pauker, Henit Yanai, Sophy Goren, Dani Cohen, Iris Dotan, Ariella Bar-Gil Shitrit   +19 more
doaj   +1 more source