Results 21 to 30 of about 242,877 (255)

Features of Crohn's Disease Depending on the Age of Disease Onset

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2023
Aim: to evaluate the characteristics of Crohn's disea depending on the age of the disease onset in patients observed in a specialized City Center for Inflammatory Bowel Diseases Diagnosis and Treatment.Materials and methods. We observed 180 patients with
E. G. Ganich, O. B. Shchukina
doaj   +1 more source

Substance P Mediates Proinflammatory Cytokine Release From Mesenteric Adipocytes in Inflammatory Bowel Disease PatientsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Substance P (SP) neurokinin-1 receptors (NK-1Rs) are expressed in mesenteric preadipocytes, and SP binding activates proinflammatory signaling in these cells. We evaluated the expression levels of SP (Tac-1), NK-1R (Tacr-1), and NK-2R (
Aristea Sideri, Kyriaki Bakirtzi, David Q. Shih, Hon Wai Koon, Phillip Fleshner, Razvan Arsenescu, Violeta Arsenescu, Jerrold R. Turner, Iordanes Karagiannides, Charalabos Pothoulakis   +9 more
doaj   +1 more source

Identification of a Novel Substance P–Neurokinin-1 Receptor MicroRNA-221-5p Inflammatory Network in Human Colonic Epithelial CellsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Substance P (SP), a neuropeptide member of the tachykinin family, plays a critical role in colitis. MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate gene expression.
Kai Fang, Aristea Sideri, Ivy Ka Man Law, Kyriaki Bakirtzi, Christos Polytarchou, Dimitrios Iliopoulos, Charalabos Pothoulakis   +6 more
doaj   +1 more source

Mesenteric excision surgery or conservative limited resection in Crohn’s disease: study protocol for an international, multicenter, randomized controlled trial

Trials, 2020
Background The structures of the mesentery including adipose tissue, nerves, and lymphatics play an important role in the pathogenesis and disease progression of Crohn’s disease (CD).
Yi Li, Helen Mohan, Nan Lan, Xiaojian Wu, Wei Zhou, Jianfeng Gong, Bo Shen, Luca Stocchi, J. Calvin Coffey, Weiming Zhu   +9 more
doaj   +1 more source

CT enterography for evaluation of disease activity in patients with ileocolonic Crohn's disease

BMC Gastroenterology, 2022
Background CT enterography (CTE) is used routinely for assessment of activity and severity in Crohn's disease (CD), but there are few CTE scoring systems.
Jinlu Tong, Qi Feng, Chenpeng Zhang, Xitao Xu, Zhihua Ran   +4 more
doaj   +1 more source

Diagnosis, prevalence, and outcomes of sarcopenia in kidney transplantation recipients: A systematic review and meta‐analysis

Journal of Cachexia, Sarcopenia and Muscle, 2023
The prevalence of sarcopenia and its clinical predictors and clinical impact vary among kidney transplant recipients (KTRs), in part because of different diagnostic criteria.
Jin‐Zhi Zhang, Wei Shi, Min Zou, Qi‐Shan Zeng, Yue Feng, Zhen‐Yi Luo, Hua‐Tian Gan   +6 more
doaj   +1 more source

Inflammatory Bowel Disease [PDF]

Annual Review of Immunology, 2010
Insights into inflammatory bowel disease (IBD) are advancing rapidly owing to immunologic investigations of a plethora of animal models of intestinal inflammation, ground-breaking advances in the interrogation of diseases that are inherited as complex genetic traits, and the development of culture-independent methods to define the composition of the ...
Arthur, Kaser, Sebastian, Zeissig, Richard S, Blumberg   +2 more
openaire   +5 more sources

Biomarkers as Potential Treatment Targets in Inflammatory Bowel Disease: A Systematic Review

Canadian Journal of Gastroenterology and Hepatology, 2015
There is increasing interest in the concept of ‘treat-to-target’ in inflammatory bowel disease as a mechanism to standardize management and prevent complications. While clinical, radiographic and endoscopic treatment end points will figure prominently in
Travis B Murdoch, Sarah O’Donnell, Mark S Silverberg, Remo Panaccione   +3 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study

BMJ Open, 2022
Introduction Inflammatory bowel diseases (IBD), encompassing Crohn’s disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract.
Johan Burisch, Lene Terslev, Mikkel Østergaard, Annette Bøjer Jensen, Frank Krieger Jensen, Flemming Bendtsen, Charlotte Wiell, Mohamed Attauabi, Klaus Theede, Viktoria Fana, Hartwig Roman Siebner, Henrik S Thomsen, Jakob M Møller, Simon Francis Thomsen, Gorm Roager Madsen, Anne Vibeke Wewer, Rune Wilkens, Johan Ilvemark, Nora Vladimirova, Sanja Bay Hansen, Yousef Jesper Wirenfeldt Nielsen, Helene Andrea Sinclair Ingels, Trine Boysen, Jacob T Bjerrum, Christian Jakobsen, Maria Dorn-Rasmussen, Sabine Jansson, Yiqiu Yao, Ewa Anna Burian, Frederik Trier Møller, Kristina Bertl, Andreas Stavropoulos, Jakob B Seidelin   +32 more
doaj   +1 more source