Results 71 to 80 of about 948,572 (352)

Inflammatory bowel diseases [PDF]

Jornal de Pediatria, 2000
OBJECTIVE: To present a review about inflammatory bowel diseases in childhood so that pediatricians become familiar with two diseases (ulcerative colitis and Crohn s disease) that are increasing in incidence. METHODS: Articles of specific gastroenterological journals were analyzed.
openaire   +2 more sources

A Replicating Single-Cycle Adenovirus Vaccine Effective against Clostridium difficile

Vaccines, 2020
Clostridium difficile causes nearly 500,000 infections and nearly 30,000 deaths each year in the U.S., which is estimated to cost $4.8 billion. C. difficile infection (CDI) arises from bacteria colonizing the large intestine and releasing two toxins ...
William E. Matchett, Stephanie Anguiano-Zarate, Goda Baddage Rakitha Malewana, Haley Mudrick, Melissa Weldy, Clayton Evert, Alexander Khoruts, Michael Sadowsky, Michael A. Barry   +8 more
doaj   +1 more source

Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll"? [PDF]

, 2006
The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved.
Fischer, Simon, Gál, István, Lakatos, László, Lakatos, Péter László, Papp, János   +4 more
core   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and AutophagySummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD).
Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney, Iulia Oancea, Gregor Kijanka, Sumaira Hasnain, Andrew J. Lucke, David P. Fairlie, Michael A. McGuckin, Timothy H. Florin, Jakob Begun   +17 more
doaj  

Meta-analysis of gene expression disease signatures in colonic biopsy tissue from patients with ulcerative colitis

Scientific Reports, 2021
Publicly available ulcerative colitis (UC) gene expression datasets from observational studies and clinical trials include inherently heterogeneous disease characteristics and methodology. We used meta-analysis to identify a robust UC gene signature from
Bryan Linggi, Vipul Jairath, Guangyong Zou, Lisa M. Shackelton, Dermot P. B. McGovern, Azucena Salas, Bram Verstockt, Mark S. Silverberg, Shadi Nayeri, Brian G. Feagan, Niels Vande Casteele   +10 more
doaj   +1 more source

MicroRNA-124 Regulates STAT3 Expression and Is Down-regulated in Colon Tissues of Pediatric Patients With Ulcerative Colitis [PDF]

, 2013
Background & Aims - Altered levels and functions of microRNAs (miRs) have been associated with inflammatory bowel diseases (IBDs), although little is known about their roles in pediatric IBD.
Alessio Morley–Fletcher, Alvarez, Ando, Androulidaki, Atreya, Bartel, Beatriz Gras–Miralles, Berg, Bousvaros, Cao, Charalabos Pothoulakis, Christos Polytarchou, Dalal, Danese, Danese, Dimitrios Iliopoulos, Du, Efi Kokkotou, Furuta, Gao, Georgios Koukos, Harland S. Winter, Hatziapostolou, Hayashi, Iliopoulos, Iliopoulos, Jess L. Kaplan, Jostins, Karamanolis, Kellermayer, Khor, Kim, Koon, Lin, Lin, Lu, Lujambio, Manfredi, Mariah Baril–Dore, Meijer, Musso, Padgett, Paraskevi, Scholmerich, Smith, Stagakis, Sugimoto, Surdziel, Willson, Wilting, Wu, Wu, Wu, Zhang   +53 more
core   +2 more sources

The perceptions of social and information privacy risks of Inflammatory Bowel Disease patients using social media platforms for health-related support [PDF]

arXiv, 2020
With hundreds of thousands of individuals using social media to discuss health concerns, sensitive personal data is self-disclosed on these platforms every day. Previous research indicates an understanding of social privacy concerns by patients with chronic illnesses, but there is a lack of understanding in the perception of information privacy ...
arxiv  

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis [PDF]

, 2014
Inflammatory bowel diseases (IBD) are emerging globally, indicating that environmental factors may be important in their pathogenesis. Colonic mucosal epigenetic changes, such as DNA methylation, can occur in response to the environment and have been ...
Bronsky, Jiri, Ferry, George D., Frank, Eibe, Harris, R. Alan, Kaplan, Jess L., Kellermayer, Richard, Mir, Sabina A.V., Nagy-Szakal, Dorottya, Opekun, Antone, Szigeti, Reka, Winter, Harland   +10 more
core   +2 more sources