Results 91 to 100 of about 242,877 (255)

T cell and cytokine signatures as early predictors of response to IL-12/IL-23 inhibition in Crohn’s disease

Frontiers in Immunology
IntroductionCrohn’s disease (CD) is a disabling inflammatory disorder with highly variable response to biologic therapies. Despite the availability of multiple biologic agents, a significant proportion of patients experience primary non-response, while ...
Eduardo Martín Arranz, Eduardo Martín Arranz, Laura García-Ramirez, Laura García-Ramirez, Ana Van Den Rym, Ana Van Den Rym, Ana Van Den Rym, Cristina Suarez, Cristina Suarez, Blanca García-Solís, Blanca García-Solís, Blanca García-Solís, Nestor Díaz-Iglesias, Nestor Díaz-Iglesias, Nestor Díaz-Iglesias, Alberto López-Lera, Fernando Corvillo, José Luis Rueda García, José Luis Rueda García, Paula Blanco-San Miguel, Paula Blanco-San Miguel, María Sánchez Azofra, María Sánchez Azofra, Joaquín Poza Cordón, Joaquín Poza Cordón, Yuval Itan, Eduardo López-Collazo, Eduardo López-Collazo, Rebeca Pérez de Diego, Rebeca Pérez de Diego, Rebeca Pérez de Diego, Rebeca Pérez de Diego, María Dolores Martín-Arranz, María Dolores Martín-Arranz, María Dolores Martín-Arranz   +34 more
doaj   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Here to Heal: Mucosal CD74 Signaling in Colitis

Cellular and Molecular Gastroenterology and Hepatology, 2020
Jill M. Hoffman, PhD, Carl R. Rankin, PhD, Charalabos Pothoulakis, MD   +2 more
doaj   +1 more source

Correction to: Prevalence and predictors of non-alcoholic liver disease on MRI among patients with Crohn‘s disease

BMC Gastroenterology, 2022
Qijin Hong, Jun Shen, Qi Feng, Qing Zheng, Yuqi Qiao   +4 more
doaj   +1 more source

Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels

mBio
Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, much effort has been dedicated to identifying effective antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Qiru Zeng, Avan Antia, Luis Alberto Casorla-Perez, Maritza Puray-Chavez, Sebla B. Kutluay, Matthew A. Ciorba, Siyuan Ding   +6 more
doaj   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source