Results 41 to 50 of about 4,711,883 (288)
Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls. [PDF]
, 2010 BACKGROUND: Truncating mutations in ATM have been shown to increase the risk of breast cancer but the effect of missense variants remains contentious.Schürmann, Peter, Olson, J.E., Seynaeve, C., Pita, Guillermo, Malcolm W.R. Reed, Beesley, Jonathan, Severi, G., Couch, Fergus J, Wang Gohrke, Shan, Jianjun Liu, Anton-Culver, H., Broeks, Annegien, Aittomaki, K., Kang, Daehee, Wang-Gohrke, Shan, Zachary Fredericksen, Hall, Katrine Blædel Pinholt, Kosma, V.M., Beckmann, Matthias W., Meindl, A., Heli Nevanlinna, Silva, Andreá Lema Da, Dunning, A.M., Morrison, J, Schmidt, Marjanka K., Keun-Young Yoo, van Leeuwen, F.E., Jenny Chang-Claude, Chang Claude, Jenny, Per Hall, Michael Bremer, Giles, Graham G., Georgia Chenevix-Trench, Fletcher, O, Noh, D.Y., Waltes, R., Brinton, L.A., Broeks, A., Bogdanova, Natalia V., Hopper, JL, Ekici, Arif B., Ashworth, Alan, Wang-Gohrke, S., Czene, Kamila, Smith, L (Letitia), Johnson, N., Orr, Nick, Spurdle, Amanda B., Van't Veer, L.J., Brinton, Louise A., Louise A. Brinton, Schurmann, P, Spurdle, AB, Flyger, Henrik, Melissa C. Southey, Kataja, V, Nordestgaard, Børge G., Douglas F. Easton, Veli-Matti Kosma, Kristiina Aittomäki, Liu, Jianjun, Elliott, Graeme, Ahmed, S., Zalutsky, Iosif V., Morrison, Jonathan, Bojesen, S.E., Breast Cancer Association Consortium, Lindblom, A., Platte, R., Platte, Radka, Spurdle, Amanda B, Kang, D., Pita, G., Johnson, N, Garcia-Closas, M., Olson, Janet E, Ko, Yon-Dschun, Nordestgaard, B.G., Antonenkova, N.N., Isabel dos Santos Silva, Fredericksen, Z, Milne, R.L., Laura Baglietto, Hopper, J.L., Cox, A, Manjeet K. Humphreys, García Closas, Montserrat, Nichola Johnson, Wang-Gohrke, S, Bojesen, Stig E., Dork, T., Milne, Roger L, Pharoah, P.D.P., Brauch, H, Brinton, LA, Reed, M.W.R., Humphreys, Manjeet K, Pita, G, Cox, Angela, Liu, J.J., Brock, I, AOCS Grp, Anton-Culver, H, Elliott, George Arthur, Olivia Fletcher, Ekici, Arif B, Marjanka K. Schmidt, Claus R. Bartram, Ian Brock, Jonathan Beesley, Bremer Michael, Peto, Julian, Johnson, Nichola, Dallas R. English, Giles, GG, Easton, Douglas F, Ashworth, A., Børge G. Nordestgaard, Alison M. Dunning, Radka Platte, Chenevix-Trench, G, Hall, Per, Lindblom, Annika, Annika Lindblom, Schurmann, P., Asperen, C.J. van, Ko, YD, GENICA Consortium, Baglietto, L, Humphreys, Manjeet K., Peter Devilee, Baglietto, Laura, Morrison, Ann Judith, Couch, FJ, Fasching, PA, Brinton, Louise A, English, Dallas R., Meindl, A, Severi, G, Brauch, H., Reed, Malcolm W. R., Nevanlinna, Heli, Burwinkel, B., Dong Young Noh, Jonathan Morrison, Bojesen, SE, John L. Hopper, Devilee, Peter, Orr, N, Javier Benítez, Hoda Anton-Culver, Lissowska, J, Tollenaar, Rob A E M, Bartram, CR, Giles, Graham G, Noh, DY, Schmidt, Marjanka K, Southey, Melissa C., Fredericksen, Z., Milne, RL, Beckmann, MW, Beesley, J, Yoo, Keun-Young, Blomqvist, Carl, Chanock, S., Milne, Roger L., Easton, Douglas F., Tuomas Heikkinen, Couch, Fergus J., Alan Ashworth, Schmidt, M.K., Benítez, Javier, Montserrat García-Closas, Wang, X.S., Giles, G.G., Fasching, Peter A., Barbara Burwinkel, Benitez, J, Schmutzler, RK, Dörk, Thilo, Peto, J., Couch, F.J., Angela Cox, Dunning, Alison M., Arif B. Ekici, Olson, Janet E., Kamila Czene, dos Santos Silva, Isabel, Mannermaa, A., Pharoah, Paul D. P., Stig E. Bojesen, Larsen, Marie Sofie Yoo, AOCS Group, Hiltrud Brauch, Blomqvist, C, Hamann, U., Chang-Claude, J., Tollenaar, Rob A. E. M., Vesa Kataja, Baglietto, L., Chenevix Trench, Georgia, Ahmed, Shahana, Strick, Reiner, Aittomaki, K, Strick, R, Bremer, M, Spurdle, A.B., Natalia V. Bogdanova, Margolin, Sara, Brock, I., Anton Culver, Hoda, Hopper, John L., Benitez, J., Hall, P, Waltes, Regina, Hamann, U, Zalutsky, Iosif V, Flora E. van Leeuwen, Anton-Culver, Hoda, Bogdanova, N.V., Antonenkova, NN, van Asperen, Christie J., Arias, J.I., Natalia N. Antonenkova, Henrik Flyger, Wang, XS, Wang, Xianshu, Liu, JJ, van Leeuwen, Flora E., Keith Humphreys, Yon-Dschun Ko, Morrison, J., Gaubert, Giles, Janet E. Olson, Silva, Isabel dos Santos, Kataja, Vesa, Beckmann, Matthias W, Fasching, P.A., van Asperen, CJ, Ekici, A.B., Breast Canc Assoc Consortium, Ziogas, A, van Asperen, Christie J, Ziogas, Argyrios, Rita K. Schmutzler, Lissowska, J., Dunning, Alison M, Heikkinen, T., Dunning, AM, Burwinkel, B, Czene, K, Broeks, A, Easton, DF, Tollenaar, Rob AEM, Tollenaar, RAEM, Kang, D, Zalutsky, IV, Hamann, Ute, Kosma, Veli-Matti, Dork,Thilo, Orr, N., English, D.R., Van't Veer, Laura J., Bogdanova, Natalia V, Chenevix-Trench, Georgia, Jolanta Lissowska, Humphreys, MK, Pharoah, Paul DP, Southey, M.C., Chang-Claude, J, Heikkinen, T, Sara Margolin, Ute Hamann, Rob A.E.M. Tollenaar, Smith, Letitia, Olson, JE, Annegien Broeks, Reed, MWR, Caroline Seynaeve, Leeuwen, F.E. van, Bremer, M., Roger L. Milne, Thilo Dörk, van Leeuwen, Flora E, Carl Blomqvist, Hall, P., Reed, Malcolm W R, Laura J. Van't Veer, Humphreys, K., Ziogas, A., Bojesen, Stig E, Schmutzler, R.K., Melanie Maranian, Ekici, AB, Iosif V. Zalutsky, Peto, J, Brauch, Hiltrud, Reed, Malcolm WR, Elliott, G., Amanda B. Spurdle, Chanock, Stephen, Julian Peto, Yoo, KY, Ignacio Arias, José, Bartram, Claus R., Smith, L., Beesley, J., Christie J. van Asperen, Beckmann, M.W., Daehee Kang, Argyrios Ziogas, van Leeuwen, FE, Strick, R., Yoo, K.Y., Arias, JI, Graeme Elliott, Devilee, P, Arias, José Ignacio, José Ignacio Arias, Ashworth, A, Hopper, John L, Nordestgaard, BG, Stephen Chanock, Lindblom, A, Meindl, Alfons, Bogdanova, NV, Hansen, Anne Lindblom, Arto Mannermaa, Humphreys, K, Margolin, S., Heikkinen, Tuomas, Ko, Yon Dschun, García-Closas, Montserrat, Fletcher, O., Flyger, H., Travis, Brandon Reed, Southey, MC, Aittomäki, Kristiina, Zalutsky, I.V., Reiner Strick, Elliott, G, Waltes, R, Nevanlinna, H., Fergus J. Couch, Schmutzler, Rita K., Orr, Nick; id_orcid, Nick Orr, English, Dallas R, van 't Veer, LJ (Laura), Guillermo Pita, Severi, Gianluca, English, DR, Yoo, Keun Young, Kosma, VM, Garcia-Closas, M, Pharoah, Paul D P, Seynaeve, Caroline, Shan Wang-Gohrke, Van't Veer, Laura J, Graham G. Giles, Devilee, P., Nordestgaard, Børge G, Antonenkova, Natalia N., Peter A. Fasching, Czene, K., Paul D.P. Pharoah, Bremer, Michael, Platte, R, Maranian, Melanie, Silva, ID, Chanock, S, Maranian, M., Fletcher, Olivia, Shahana Ahmed, Burwinkel, Barbara, Humphreys, M.K., Southey, Melissa C, Pharoah, PDP, Antonenkova, Natalia N, Flyger, H, Margolin, S, Matthias W. Beckmann, Alfons Meindl, Mannermaa, A, Schmutzler, Rita K, Noh, Dong Young, Tollenaar, R.A.E.M., Dork, T, Cox, A., Nevanlinna, H, Bartram, Claus R, van Asperen, C.J., Kosma, Veli Matti, Ahmed, S (Shahana), Mannermaa, Arto, Easton, D.F., Chang-Claude, Jenny, Lissowska, Jolanta, Peter Schürmann, Ko, Y.D., Xianshu Wang, Brock, Ian, Silva, I.D., Chenevix-Trench, G., Kataja, V., Maranian, M, Humphreys, Keith, Fasching, Peter A, Regina Waltes, Fredericksen, Zachary, Gianluca Severi, Blomqvist, C., Letitia Smith, Bartram, C.R., kConFab Investigators, Silva, IDS, Fletcher, O;Johnson, N;Dos Santos Silva, I;Orr, N;Ashworth, A;Nevanlinna, H;Heikkinen, T;Aittomäki, K;Blomqvist, C;Burwinkel, B;Bartram, CR;Meindl, A;Schmutzler, RK;Cox, A;Brock, I;Elliott, G;Reed, MW;Southey, MC;Smith, L;Spurdle, AB;Hopper, JL;Couch, FJ;Olson, JE;Wang, X;Fredericksen, Z;Schürmann, P;Waltes, R;Bremer, M;Dörk, T;Devilee, P;van Asperen, CJ;Tollenaar, RA;Seynaeve, C;Hall, P;Czene, K;Humphreys, K;Liu, J;Ahmed, S;Dunning, AM;Maranian, M;Pharoah, PD;Chenevix-Trench, G;Beesley, J;Bogdanova, NV;Antonenkova, NN;Zalutsky, IV;Anton-Culver, H;Ziogas, A;Brauch, H;Ko, YD;Hamann, U;Fasching, PA;Strick, R;Ekici, AB;Beckmann, MW;Giles, GG;Severi, G;Baglietto, L;English, DR;Milne, RL;Benitez, J;Arias, JI;Pita, G;Nordestgaard, BG;Bojesen, SE;Flyger, H;Kang, D;Yoo, KY;Noh, DY;Mannermaa, A;Kataja, V;Kosma, VM;Garcia-Closas, M;Chanock, S;Lissowska, J;Brinton, LA;Chang-Claude, J;Wang-Gohrke, S;Broeks, A;Schmidt, MK;van Leeuwen, FE;Van't Veer, LJ;Margolin, S;Lindblom, A;Humphreys, MK;Morrison, J;Platte, R;Easton, DF +416 morecore +1 more sourceRisk determination and prevention of breast cancer [PDF]
, 2014 Breast cancer is an increasing public health problem. Substantial advances have been made in the treatment of breast cancer, but the introduction of methods to predict women at elevated risk and prevent the disease has been less successful.Howell, Anthony; id_orcid, Anderson, Annie, Key, Timothy, Montserat Garcia-Closas, A. Howell (7638146), Saxton, John, M. N. Harvie (7671182), J. M. Saxton (7638221), Annie S Anderson, Saxton, John M, Robert B Clarke, Michelle N Harvie, Evans, Gareth, Key, Timothy J., M. Garcia-Closas (7638116), Garcia-Closas, Montserat, Andy J. Gescher (7671179), Clarke, Robert; id_orcid, D. G. Evans (7608134), Gescher, Andy J, Stephen W Duffy, Key, Timothy J, Clarke, Robert, Harvie, Michelle N., Harvie, Michelle, Anthony Howell, Anderson, Annie S.; id_orcid, D Gareth Evans, John M Saxton, T. J. Key (7638161), Duffy, Stephen W., Anderson, Annie S, R. B. Clarke (7638080), Andy J Gescher, Clarke, Robert B., Saxton, John M., Duffy, Stephen W, Evans, Gareth; id_orcid, Duffy, Stephen, S. W. Duffy (7638095), Timothy J Key, A. S. Anderson (7638050), Howell, Anthony, Gescher, Andy, Evans, D. Gareth, Gescher, Andy J. +45 morecore +2 more sourcesPeroxisome proliferator activated receptor-α/hypoxia inducible factor-1α interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells. [PDF]
PLoS ONE, 2013 AIMS: Cancer stem cell biology is tightly connected to the regulation of the pro-inflammatory cytokine network. The concept of cancer stem cells "inflammatory addiction" leads to envisage the potential role of anti-inflammatory molecules as new anti ...Alessio Papi, Gianluca Storci, Tiziana Guarnieri, Sabrina De Carolis, Sara Bertoni, Nicola Avenia, Alessandro Sanguinetti, Angelo Sidoni, Donatella Santini, Claudio Ceccarelli, Mario Taffurelli, Marina Orlandi, Massimiliano Bonafé +12 moredoaj +1 more sourceAssociation of genetic variants at 8q24 with breast cancer risk. [PDF]
, 2008 Recent whole genome association studies of prostate, breast, and colorectal cancer have identified susceptibility loci on 8q24. We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both ...Johnson, Nichola, Fletcher, Olivia, Coupland, Ben, dos Santos Silva, Isabel, Gibson, Lorna, Leonard, Angela, Fraser, Agnes, Ashworth, Alan, Houlston, Richard, Peto, Julian +9 morecore +1 more sourceMetastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano +2 morewiley +1 more sourcep53 mutation, deprivation and poor prognosis in primary breast cancer [PDF]
, 2010 Background: The deprivation gap for breast cancer survival remains unexplained by stage at presentation, treatment, or co-morbidities. We hypothesised that p53 mutation might contribute to the impaired outcome observed in patients from deprived ...P R Quinlan, L Baker, Bourdon, J-C; id_orcid, Baker, L., C A Purdie, Birse-Stewart-Bell, L-J, Dewar, J.A., Dewar, J. A., J A Dewar, A M Thompson, Thompson, A.M., Birse-Stewart-Bell, L.-J., Purdie, C.A., Quinlan, P. R., Quinlan, P.R., Ashfield, A., C McCowan, J-C Bourdon, Jordan, L.B., Thompson, A.M, Wu, L., L-J Birse-Stewart-Bell, A Ashfield, L Wu, Patten, N., N Patten, Mccowan, C., Jordan, L. B., Bourdon, J.-C., Purdie, C. A., L B Jordan, Mccowan, C.; id_orcid +31 morecore +1 more sourceNeutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang +8 morewiley +1 more source
