Results 41 to 50 of about 301,386 (199)

The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development [PDF]

, 2020
Many inflammation-associated diseases, including cancers, increase in women after menopause and with obesity. In contrast to anti-inflammatory actions of 17β-estradiol, we find estrone, which dominates after menopause, is pro-inflammatory.
Nunes de Paiva, Vanessa, D’Amico, Massimo, Thaller, Seth R., Vivanco, Maria del Mar, Morata-Tarifa, Cynthia, Ince, Tan, Slingerland, Joyce M, Rodgers, Steven E., Kesmodel, Susan, Lippman, Marc E., Radhakrishnan, Ramya, Qureshi, Rehana, Picón Ruiz, Manuel, Lippman, Marc E, D'Amico, Massimo, Aurrekoetxea-Rodriguez, Iskander, Yoon, Hyunho, Thaller, Seth R, Picon-Ruiz, Manuel, Slingerland, Joyce M., Rodgers, Steven E   +20 more
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Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy : results from the BIG 02-98 phase III trial [PDF]

, 2012
Introduction: Pre-clinical data suggest p53-dependent anthracycline-induced apoptosis and p53-independent taxane activity. However, dedicated clinical research has not defined a predictive role for TP53 gene mutations. The aim of the current study was to
Emmanuel Quinaux, Prudence A Francis, Lynnette Fernández-Cuesta, Dell'Orto, P, P. Falagan Lotsch, C. Oakman, A. D. Leo, Pierre Hainaut, Hainaut, P, Azambuja, Evandro De, P. A. Francis, Magali Olivier, D. Larsimont, Larsimont, D, E. Quinaux, G. Viale, Dolci, M Stella, M. S. Dolci, Martine Piccart-Gebhart, Francis, Prudence A, Oakman, C, Dell'orto, Patrizia, Viale, Giuseppe, Evandro De Azambuja, Priscila Falagan-Lotsch, Olivier, Magali, Crown, John, L. Fernández Cuesta, Ke-seay Smoth, Hainaut, Pierre, John Crown, Fernández-Cuesta, L, Viale, G, Leo, Angelo, Larsimont, Denis, M. Piccart Gebhart, Fernández-Cuesta, Lynnette, de Azambuja, Evandro, Giuseppe Viale, Falagan-Lotsch, P, Crown, J, Patrizia Dell'Orto, Piccart-Gebhart, Martine, M Stella Dolci, Piccart-Gebhart, M, Buyse, Marc, Quinaux, E, Denis Larsimont, M. Olivier, M. Buyse, Catherine Oakman, Quinaux, Emmanuel, P. Dell'orto, Olivier, M, Oakman, Catherine, Dolci, MS, Leo, Angelo Di, Buyse, M, Smoth, Ke-Seay, P. Hainaut, Smoth, KS, Azambuja, ED, Angelo Di Leo, J. Crown, Leo, AD, Dolci, Stella, E. D. Azambuja, Francis, P, Francis, PA, Falagan-Lotsch, Priscila, Marc Buyse, K. Smoth   +71 more
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Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles [PDF]

, 2020
Cellular senescence is a potent tumor-suppressive program that prevents neoplastic events. Paradoxically, senescent cells develop an inflammatory secretome, termed the senescence-associated secretory phenotype (SASP), which is implicated in age-related ...
Jiang, Jing, Cao, Liu, Xu, Qixia, Lam, Eric W-F, Jiramongkol, Yannasittha, Han, Liu, Chin, Y Eugene, Sun, Yu, Qian, Min, Zhang, Boyi, Li, Shenjun, Guo, Jianming, Long, Qilai, Dou, Xuefeng   +13 more
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Cumulative environmental quality is associated with breast cancer incidence differentially by summary stage and urbanicity

Scientific Reports, 2023
Individual environmental contaminants have been associated with breast cancer; however, evaluations of multiple exposures simultaneously are limited. Herein, we evaluated associations between breast cancer summary stages and the Environmental Quality ...
Larisa M. Gearhart-Serna, Brittany A. Mills, Hillary Hsu, Oluwadamilola M. Fayanju, Kate Hoffman, Gayathri R. Devi   +5 more
doaj   +1 more source

Changes over time in socioeconomic inequalities in breast and rectal cancer survival in England and Wales during a 32-year period (1973-2004): the potential role of health care. [PDF]

, 2011
BACKGROUND: Socioeconomic inequalities in cancer survival are well documented but they vary for different cancers and over time. Reasons for these differences are poorly understood.
B. Rachet, Coleman, MP, G. Lyratzopoulos, Lyratzopoulos, G, Baum, M, Thompson, MR, J.M. Barbiere, M. Baum, Rachet, B, M.R. Thompson, M.P. Coleman, Barbiere, JM   +11 more
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Effects of an exercise and hypocaloric healthy eating intervention on indices of psychological health status, hypothalamic-pituitary-adrenal axis regulation and immune function after early-stage breast cancer: a randomised controlled trial [PDF]

, 2014
Introduction : Many women experience emotional distress, depression and anxiety after a diagnosis of breast cancer. Psychological stress and depression have been associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation that may adversely ...
Scott, Emma, Woodroofe, Nicola, Coleman, R. E., Helen Crank, Coleman, Robert, Powers, Hilary J, Mutrie, N., Powers, Hilary, John M Saxton, Powers, H.J., Crank, H., Powers, Hilary J., Saxton, John, Saxton, John M, Crank, Helen, Saxton, J.M., Robert E Coleman, Daley, A.J., Daley, Amanda J, Saxton, John M., Amanda J Daley, Emma J Scott, Powers, H. J., Coleman, R.E., Scott, E.J., Woodroofe, M.N., Hilary J Powers, Daley, Amanda, Scott, E. J., M Nicola Woodroofe, Scott, Emma J, Mutrie, Nanette, Coleman, Robert E, Daley, A. J., Nanette Mutrie, Woodroofe, M Nicola   +35 more
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Peroxisome proliferator activated receptor-α/hypoxia inducible factor-1α interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells. [PDF]

PLoS ONE, 2013
AIMS: Cancer stem cell biology is tightly connected to the regulation of the pro-inflammatory cytokine network. The concept of cancer stem cells "inflammatory addiction" leads to envisage the potential role of anti-inflammatory molecules as new anti ...
Alessio Papi, Gianluca Storci, Tiziana Guarnieri, Sabrina De Carolis, Sara Bertoni, Nicola Avenia, Alessandro Sanguinetti, Angelo Sidoni, Donatella Santini, Claudio Ceccarelli, Mario Taffurelli, Marina Orlandi, Massimiliano Bonafé   +12 more
doaj   +1 more source

A New N-staging System for Predicting Postoperative Survival of M0 Stage Inflammatory Breast Cancer

Zhongliu Fangzhi Yanjiu, 2022
Objective To establish a new N-stage system combining the number of metastatic lymph nodes and the ratio of metastatic lymph nodes for postoperative M0 stage inflammatory breast cancer patients.
SUI Daxing, WANG Xueying, ZHANG Jiaxin
doaj   +1 more source

An update on inflammatory breast cancer

Oncology Reviews, 2011
Inflammatory breast cancer is one of the most aggressive forms of breast cancer. Once considered to be a uniformly fatal disease, treatment of this entity has evolved significantly over the last two decades.
P. Thapaliya, N. J. Karlin
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Blockade of store-operated calcium entry sensitizes breast cancer cells to cisplatin therapy via modulating inflammatory response

Saudi Pharmaceutical Journal, 2023
Store-operated calcium entry (SOCE) is an important pathway for calcium signaling that regulates calcium influx across the plasma membrane upon the depletion of calcium stores in the endoplasmic reticulum.
Abdullah S. Alhamed, Mohammed Alqinyah, Musab A. Alsufayan, Ibrahim A. Alhaydan, Yasseen A. Alassmrry, Hajar O. Alnefaie, Mohammad M. Algahtani, Adel F. Alghaith, Hussain N. Alhamami, Abdullah M. Albogami, Khalid Alhazzani, Alanazi AZ   +11 more
doaj   +1 more source