Results 51 to 60 of about 291,938 (249)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Diversity and heterogeneity in human breast cancer adipose tissue revealed at single-nucleus resolution

Frontiers in Immunology, 2023
IntroductionThere is increasing awareness of the role of adipose tissue in breast cancer occurrence and development, but no comparison of adipose adjacent to breast cancer tissues and adipose adjacent to normal breast tissues has been reported ...
Lina Tang, Tingting Li, Jing Xie, Yanping Huo, Jianping Ye, Jianping Ye, Jianping Ye   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Altered ribosomal profile in acquired resistance and reversal associates with pathological response to chemotherapy in inflammatory breast cancer

npj Breast Cancer
Therapeutic resistance presents a significant hurdle in combating inflammatory breast cancer (IBC), adding to the complexity of its management. To investigate these mechanisms, we conducted a comprehensive analysis using transcriptomic and proteomic ...
Gayathri R. Devi, Pritha Pai, Seayoung Lee, Matthew W. Foster, Dorababu S. Sannareddy, Francois Bertucci, Naoto Ueno, Steven Van Laere   +7 more
doaj   +1 more source

Improving the quality of life of people with advanced breast cancer: a global expert review and call-to-action for 2025–2035 (goal 3)

Breast
Progress in the treatment landscape for advanced breast cancer (ABC) has significantly extended the survival of people with the disease. However, longevity alone is insufficient; maintaining and enhancing quality of life (QoL) is vital to ensure that ...
Karen Gelmon, Cynthia Villarreal-Garza, Dawn Aubel, Hope S. Rugo, Julia Maués, Luzia Travado, Matthijs Van Meerveld, Runcie C.W. Chidebe, Bianca Patel, Georgia Attfield, Alexandra Lewis, Fatima Cardoso   +11 more
doaj   +1 more source

A rim-enhanced mass with central cystic changes on MR imaging: how to distinguish breast cancer from inflammatory breast diseases?

PLoS ONE, 2014
ObjectiveTo evaluate the capacity of magnetic resonance imaging (MRI) to distinguish breast cancer from inflammatory breast diseases manifesting as a rim-enhanced mass with central cystic changes.Materials and methodsForty cases of breast cancer and 52 ...
Lijun Wang, Dengbin Wang, Xiaochun Fei, Mei Ruan, Weimin Chai, Lin Xu, Xiaoxiao Li   +6 more
doaj   +1 more source

Inflammatory breast cancer associated with amyopathic dermatomyositis: a case report

Surgical Case Reports, 2020
Background Dermatomyositis is associated with malignant tumors including breast cancer, and inflammatory breast cancer is considered to have a poorer prognosis than most breast cancers.
Gaku Inaguma, Akihiko Shimada, Junya Tsunoda, Tomohiko Matsuzaki, Tomohiko Nishi, Hiroaki Seki, Hidetoshi Matsumoto   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source