Results 91 to 100 of about 2,144,005 (298)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Expression of inflammatory and non-inflammatory cytokines.

, 2015
Six-micrometer sections of pig brain tissues proximal to installed parasites and sections of an equivalent region from sham-operated pigs (40X) were incubated with antibodies against inflammatory cytokines (IL-17, TNF-α, and IL6), the non-inflammatory ...
Humberto Cisneros (781352), Raul J. Bobes (5664664), Armando Trejo (781351), Roberto García-Navarrete (781353), Marisela Hernández (363819), Juana Villeda Hernández (781354), Nelly Villalobos (363809), Gabriela Rosas (363794), Beatriz Hernández (363797), Agnès Fleury (362463), Edda Sciutto (362469), Gladis Fragoso (363818), Aline S. de Aluja (363812)   +12 more
core   +1 more source

A Possible Change Process of Inflammatory Cytokines in the Prolonged Chronic Stress and Its Ultimate Implications for Health

The Scientific World Journal, 2014
Sustained stress triggers series of changes in the brain and the body. At the early stage of stress, the activated hypothalamus-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) axis can upregulate the levels of glucocorticoid (GCs) and ...
Rui Tian, Gonglin Hou, Dan Li, Ti-Fei Yuan   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Cytokines and pulmonary inflammatory and immune diseases [PDF]

, 1999
Cytokines are important soluble signalling molecules that dictate and coordinate inflammatory and immune responses. Further understanding the role of cytokines in the pathobiologic mechanisms of pulmonary inflammatory and immune diseases holds the ...
Gauldie, J., Xing, Z., Wang, J., Jordana, M.   +3 more
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Effects of inhibiting pro-inflammatory cytokines.

, 2013
Effects of inhibiting pro-inflammatory cytokines.
Andrea L. Graham (304605), Hao Hong Yiu (304604), Robert F. Stengel (304606)   +2 more
core   +1 more source

The Effect of Physical Activity on Cytokine Production: A Systematic Parallel Study of Horse and Human Athletes

International Journal of Equine Science
Cytokines are glycoproteins responsible for cellular communication, influenced by exercise. Their levels vary depending on the intensity and type of physical activity in both humans and horses. This review aimed to assess the effects of various types and
Ifeoluwa Peace Oladapo, Abolaji Samson Olagunju, Olalekan Chris Akinsulie, Eduarda Proença, Ursula Yaeko Yoshitani, Marcelo Beltrão Molento   +5 more
doaj   +1 more source

Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock

Brazilian Journal of Infectious Diseases, 2011
Background: Severe pathogenic infection triggers excessive release of cytokines as part of the massive inflammatory response associated with septic shock.
Aida Abdelhamid Korish, PhD, Maha Mohamed Arafa, KSUFSP   +1 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source