Results 91 to 100 of about 18,649 (278)

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies – A longitudinal study [PDF]

Aim: To explore if patient global assessment (PGA) is associated with inflammation over time and if associations are explained by other measures of disease activity and function in patients with idiopathic inflammatory myopathies (IIM).Methods: PGA and ...
Mercado m．, Vazquez-Del, Lilleker, James B., Leonard, Dag,, Lodin, Karin, Vencovsky, Jiri, Vazquez -Del Mercado, M., Mercado, Mónica Vázquez-Del, Lundberg, Ingrid, Alexanderson, Helene,, Shinjo, Samuel Katsuyuki,, Leonard, Dag, Lilleker, James B, Maurer, Britta,, Andersson, Helena,, Maurer, Britta, Espinosa-Ortega, Fabricio, Lundberg, Ingrid E.,, Chinoy, Hector, Griger, Zoltan, Ceribelli, Angela, Vazquez -Del Mercado, M.,, Torres-Ruiz, Jiram,, Espinosa-Ortega, Fabricio,, Lundberg, Ingrid e., Andersson, Helena, Vasquez-Del Mercado, Monica, Lundberg, Ingrid E, Chinoy, Hector; id_orcid, Lodin, Karin,, Lilleker, James B.,, Ceribelli, Angela,, Dastmalchi, Maryam,, Alexanderson, Helene, Chinoy, Hector,, Griger, Zoltan,, Torres-Ruiz, Jiram, Shinjo, Samuel katsuyuki, Dastmalchi, Maryam, Vencovsky, Jiri,, Lilleker, James b.; id_orcid   +39 more
core   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Immune-Mediated Necrotizing Myopathy: An Often Misdiagnosed Entity

European Journal of Case Reports in Internal Medicine, 2015
Immune-mediated necrotizing myopathies (IMNM) are recognized as a subgroup of idiopathic inflammatory myopathies (IIM). IMNM are defined based on a combination of clinical presentation and laboratory studies, requiring a specific myopathological pattern ...
Joana Almeida Espírito Santo, Rui Garcia, Benilde Barbosa, Olinda Rebelo, José Pereira de Moura   +4 more
doaj   +1 more source

Patients on statins with elevated transaminases: Frequency of follow‐up creatine kinase testing and gastroenterology referral

British Journal of Clinical Pharmacology, EarlyView.
Abstract Purpose To quantify how often creatine kinase (CK) is measured after newly elevated aminotransferases in statin users, and whether absent CK data are associated with gastroenterology (GI) referrals. Methods Retrospective chart review of adult outpatients on statins with a first alanine/aspartate aminotransferase (ALT/AST) elevation during a 5 ...
Faris Shweikeh, Anas Kartoumah, Rajshri Joshi, Anjali Nadihaan, Mohammed Mouchli, Inderprit Singh   +5 more
wiley   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Incidence and outcomes of neuromuscular immune-related adverse events in head and neck cancer patients treated with checkpoint inhibitors

Scientific Reports
Immune checkpoint inhibitors (ICIs) are a transformative therapy for many cancers, including head and neck cancer (HNC). However, their unique mechanism can trigger immune-related adverse events.
Stefanie Glaubitz, Jana Zschüntzsch, Andreas Sakkas, Mario Scheurer, Frank Wilde, Alexander Schramm, Marcel Ebeling   +6 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Value of serum muscle enzymes in the differential diagnosis of myopathies

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To explore the expression differences of serum muscle enzymes among different types of myopathies and viral hepatitis. Methods This study enrolled 578 patients with myopathies and 51 patients with viral hepatitis from January to September 2018.
Yuan-yuan MA, Meng YU, Xiao-fang LI, Zhi-ying XIE, Xue-ying LI, Zhe ZHANG, Yun YUAN, Zhao-xia WANG   +7 more
doaj  

Autoimmune inflammatory myopathies

, 2007
The autoimmune inflammatory myopathies constitute a heterogeneous group of acquired myopathies that have in common the presence of endomysial inflammation and moderate to severe muscle weakness. Based on currently evolved distinct clinical, histologic, immunopathologic, and autoantibody features, these disorders can be best classified as ...
openaire   +4 more sources