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Pediatric immune-mediated necrotizing myopathy
Frontiers in Neurology, 2023 Immune-mediated necrotizing myopathy (IMNM) is a type of inflammatory myopathy. Most patients with IMNM produce anti-3-hydroxy-3-methylglutaryl coenzyme A reductase or anti-signal-recognition particle autoantibodies.
Wen-Chen Liang
exaly +3 more sources
SAGE Open Medical Case Reports, 2023 Although 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors are well tolerated, a small subset of patients may develop autoimmune myopathy, classified as immune-mediated necrotizing myopathy.
Marina Roytman, Hunza Chaudhry
exaly +2 more sources
Statin-Induced Autoimmune Necrotizing Myopathy
Journal of Primary Care and Community Health, 2021 Statin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key ...
exaly +2 more sources
Monoclonal gammopathy of undetermined significance with associated necrotizing myopathy: a case report and review of the literature [PDF]
European Journal of Case Reports in Internal MedicineBackground:Â Monoclonal gammopathies encompass many types of plasma cell proliferative disorders ranging from benign to malignant. Monoclonal gammopathies that meet diagnostic criteria for monoclonal gammopathies of undetermined significance (MGUS) but ...
Anna Bode +3 more
doaj +2 more sources
Diagnostics, 2021 Immune-mediated necrotizing myopathy, a new subgroup of inflammatory myopathies, usually begins with subacute onset of symmetrical proximal muscle weakness.
Sunha Park, Dae-Hyun Jang, Jae Min Kim
exaly +3 more sources
Statinâassociated necrotizing autoimmune myopathy with concurrent myasthenia gravis
Clinical Case Reports (discontinued), 2021 Statin treatment has been associated with necrotizing autoimmune myopathy and has been linked to myasthenia gravis. We present an unprecedented clinical challenge with both disorders occurring in a patient treated with statins few months earlier.
Emma Frasson +2 more
exaly +2 more sources
Statin-induced necrotizing autoimmune myopathy: an extremely rare adverse effect from statin use
Journal of Community Hospital Internal Medicine Perspectives, 2019 Statins are widely prescribed medications to prevent cardiovascular events. While self-limited statin myopathy is relatively common, statin-induced necrotizing autoimmune myopathy (SINAM) is extremely uncommon, with incidence of two cases per million per
Rashmi Dhital +2 more
exaly +2 more sources
Beyond the Generalized Weakness: A Rare Case of Statin-Induced Immune-Mediated Necrotizing Myopathy [PDF]
Journal of Investigative Medicine High Impact Case ReportsStatin-induced immune-mediated necrotizing myopathy (IMNM) is a rare subtype of idiopathic inflammatory myopathy associated with statin exposure and characterized by positive anti-hydroxymethylglutaryl coenzyme A reductase antibodies. Here, we describe a
Leo Sakai DO +2 more
doaj +2 more sources
Emerging atypical clinicopathological manifestations of immune-mediated necrotizing myopathy (IMNM) [PDF]
Neuromuscular Disorders, Teerin Liewluck, Andrew Mammen
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A Case Report of Statin-Induced Immune-Mediated Necrotizing Myopathy Treatment Challenges
Case Reports in Rheumatology, 2022 Statin-induced necrotizing autoimmune myopathy is an immune-mediated necrotizing myopathy related to the use of statins. It is a very rare disease, which usually presents with proximal muscle weakness and frank elevation in creatine kinase levels ...
Anwar I. Joudeh +5 more
doaj +1 more source