The Sterile Inflammatory Response [PDF]
Annual Review of Immunology, 2010 The acute inflammatory response is a double-edged sword. On the one hand, it plays a key role in initial host defense, particularly against many infections. On the other hand, its aim is imprecise, and as a consequence, when it is drawn into battle, it can cause collateral damage in tissues.
Kenneth L, Rock +3 more
openaire +2 more sources
Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice [PDF]
, 2013 We combined in silico, in vivo, and in vitro studies to gain insights into age-dependent changes in acute inflammation in response to bacterial endotoxin (LPS). Time-course cytokine, chemokine, and NO2-/NO3- data from "middle-aged" (6-8 months old) C57BL/
Vodovotz, Yoram +36 more
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Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation [PDF]
, 2010 Introduction: Hypothermia improves survival and neurological recovery after cardiac arrest. Pro-inflammatory cytokines have been implicated in focal cerebral ischemia/reperfusion in-jury.
Meybohm, Patrick +17 more
core +1 more source
Clinical & Translational Immunology, 2021 Objectives Inhibitors of bromodomain and extra terminal domain (BET) proteins are a new and growing class of anti‐cancer drugs, which decrease oncogene expression by targeting superenhancers.
Zeinab Dalloul +14 more
doaj +1 more source
Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus
Viruses, 2017 Reovirus is under development as a therapeutic for numerous types of cancer. In contrast to other oncolytic viruses, the safety and efficacy of reovirus have not been improved through genetic manipulation.
Emily J. Simon +3 more
doaj +1 more source
Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent
Journal of Immunology Research, 2019 Meningococcal disease such as sepsis and meningitidis is hallmarked by an excessive inflammatory response. The causative agent, Neisseria meningitidis, expresses the endotoxin lipooligosaccharide (LOS) that is responsible for activation of immune cells ...
Berhane Asfaw Idosa +6 more
doaj +1 more source
Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses
eLife, 2022 Natural killer (NK) cells recognize and kill target cells undergoing different types of stress. NK cells are also capable of modulating immune responses. In particular, they regulate T cell functions.
Sara G Dosil +12 more
doaj +1 more source
Network Representation Learning-Based Drug Mechanism Discovery and Anti-Inflammatory Response Against COVID-19 [PDF]
, 2021 Recent studies have been demonstrated that the excessive inflammatory response is an important factor of death in COVID-19 patients. In this study, we proposed a network representation learning-based methodology, termed AIdrug2cov, to discover drug ...
Fei, Li +7 more
core +1 more source
Systemic Inflammatory Response Index, a Potential Inflammatory Biomarker in Disease Severity of Myasthenia Gravis: A Pilot Retrospective Study [PDF]
Journal of Inflammation ResearchSuwen Huang,1,* Yanchu Wang,1,2,* Jinrong Zhu,1,3,* Shengqi Li,1,2 Shenyi Lin,1,2 Wei Xie,1,2 Siyao Chen,1,2 Yukai Wang,1,3 Lingsheng Wang,1,2 Qiaoqiao Jin,1,2 Yiyun Weng,1 Dehao Yang4 1Department of Neurology, The First Affiliated Hospital ...
Huang S +11 more
doaj +1 more source
Oxygen Increases Lung Inflammatory Response in Spontaneous One-Lung Ventilation in Rabbits: A Prospective Randomized Experimental Study [PDF]
, 2014 Study objective: The purpose of this study was to investigate if oxygen supplementation would increase lung inflammatory response in a spontaneous one-lung ventilation animal model, when compared to room-air oxygen fraction.
Couceiro, A. +5 more
core +2 more sources