Results 51 to 60 of about 241,831 (245)

EPIDEMIC RISE OF INFLUENZA IN ST. PETERSBURG IN JANUARY-MARCH 2018

Инфекция и иммунитет, 2018
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M. A. Bichurina, P. A. Petrova, A. A. Go, I. G. Chkhyndzheriya, L. V. Voloshchuk, M. M. Pisareva, N. I. Konovalova   +6 more
doaj   +1 more source

Safety and Immunogenicity of Betuvax-CoV-2, an RBD-Fc-Based SARS-CoV-2 Recombinant Vaccine: Preliminary Results of the First-in-Human, Randomized, Double-Blind, Placebo-Controlled Phase I/II Clinical Trial

Vaccines, 2023
COVID-19, being a life-threatening infection that evolves rapidly, remains a major public health concern calling for the development of vaccines with broad protection against different pathogenic strains and high immunogenicity.
Aleksandr V. Kudriavtsev, Anna V. Vakhrusheva, Nickolay A. Kryuchkov, Maria E. Frolova, Konstantin A. Blagodatskikh, Taras V. Ivanishin, Milana Djonovic, Ekaterina A. Romanovskaya-Romanko, Anton N. Kovalenko, Dmitry A. Lioznov, Tatiana G. Zubkova, Svetlana V. Teplykh, Rodion A. Oseshnyuk, Marina A. Stukova, Artur A. Isaev, Igor V. Krasilnikov   +15 more
doaj   +1 more source

Influenza A H5N1 Replication Sites in Humans

Emerging Infectious Diseases, 2005
Tissue tropism and pathogenesis of influenza A virus subtype H5N1 disease in humans is not well defined. In mammalian experimental models, H5N1 influenza is a disseminated disease. However, limited previous data from human autopsies have not shown evidence of virus dissemination beyond the lung.
Uiprasertkul, M, Puthavathana, P, Nicholls, JM, Peiris, M, Auewarakul, P, Vanprapar, N, Chokephaibulkit, K, Srisook, K, Pooruk, P, Sangsiriwut, K   +9 more
openaire   +5 more sources

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Enhancement of the Influenza Surveillance System in the Russian Federation: the Main Results of the Sentinel Surveillance for Influenza and other Acute Respiratory Viral Infections

Эпидемиология и вакцинопрофилактика, 2017
Existing influenza surveillance system is constantly improved to obtain comprehensive information for understanding of continuously changing situation with the influenza, which is a consequence of the highest variability of the pathogen, its ability to ...
A. A. Sominina, E. A. Smorodintseva, K. A. Stolyarov, A. A. Mel'nikova   +3 more
doaj   +1 more source

Antiviral responses by Swine primary bronchoepithelial cells are limited compared to human bronchoepithelial cells following influenza virus infection. [PDF]

PLoS ONE, 2013
Swine generate reassortant influenza viruses because they can be simultaneously infected with avian and human influenza; however, the features that restrict influenza reassortment in swine and human hosts are not fully understood.
Mary J Hauser, Daniel Dlugolenski, Marie R Culhane, David E Wentworth, S Mark Tompkins, Ralph A Tripp   +5 more
doaj   +1 more source

Human influenza virus recognition of sialyloligosaccharides [PDF]

FEBS Letters, 1995
Sialic acids are essential components of cell‐surface receptors utilized by influenza viruses. To evaluate the recognition of asialic sugar parts of the receptor, three representative strains of human influenza A and B viruses were tested for their binding of a panel of sialyloligosaccharides.
A.M. Sakharov, N. V. Bovin, Alexander B. Tuzikov, V. E. Piskarev, A.S. Gambaryan, Mikhail Matrosovich, Igor A. Yamskov, Nikolay E. Nifant'ev   +7 more
openaire   +3 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source