Results 21 to 30 of about 48,199 (194)

Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine [PDF]

, 2014
Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine ...
A. L. Vincent, Anderson, Bao, Bowman, Brown, Centers for Disease Control and Prevention, Core Team R, D. F. Burke, Darriba, De Jong, E. Skepner, Edgar, Feng, Fouchier, Garten, Gauger, Harmon, Hinshaw, Houser, Karasin, Kawaoka, Khurana, Kitikoon, Koel, Lewis, Lindstrom, Lorusso, Loving, Maddison, Miller, Montalvao, Myers, N. S. Lewis, Nelson, Nelson, Nfon, Olsen, P. Kitikoon, Paradis, Pena, Polewicz, PyMOL, Röhm, Salmon, Shinde, Skowronski, Smith, Smith, Stamatakis, T. K. Anderson, Tong, Tong, Vincent, Vincent, Vincent, Vincent, Webby, Webby, Ye   +58 more
core   +1 more source

Compositional Constraint Is the Key Force in Shaping Codon Usage Bias in Hemagglutinin Gene in H1N1 Subtype of Influenza A Virus

International Journal of Genomics, 2014
It is vital to unravel the codon usage bias in order to gain insights into the evolutionary forces dictating the viral evolution process. Influenza A virus has attracted attention of many investigators over the years due to high mutation rate and being ...
H. Deka, S. Chakraborty
semanticscholar   +1 more source

Seroepidemiologic Effects of Influenza A(H1N1)pdm09 in Australia, New Zealand, and Singapore

Emerging Infectious Diseases, 2013
To estimate population attack rates of influenza A(H1N1)pdm2009 in the Southern Hemisphere during June–August 2009, we conducted several serologic studies. We pooled individual-level data from studies using hemagglutination inhibition assays performed in
James M. Trauer, Don Bandaranayake, Robert Booy, Mark I. Chen, Michelle Cretikos, Gary K. Dowse, Dominic E. Dwyer, Michael E. Greenberg, Q. Sue Huang, Gulam Khandaker, Jen Kok, Karen L. Laurie, Vernon J. Lee, Jodie McVernon, Scott Walter, Peter G. Markey   +15 more
doaj   +1 more source

Diagnostic approach for the differentiation of the pandemic influenza A(H1N1)v virus from recent human influenza viruses by real-time PCR. [PDF]

PLoS ONE, 2010
BACKGROUND: The current spread of pandemic influenza A(H1N1)v virus necessitates an intensified surveillance of influenza virus infections worldwide. So far, in many laboratories routine diagnostics were limited to generic influenza virus detection only.
Martin Schulze, Andreas Nitsche, Brunhilde Schweiger, Barbara Biere   +3 more
doaj   +1 more source

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus [PDF]

, 2018
Aim: The only small molecule drugs currently available for treatment of influenza A virus (IAV) are M2 ion channel blockers and sialidase inhibitors. The prototype thiazolide, nitazoxanide, has successfully completed Phase III clinical trials against ...
Andrew V Stachulski, Brian M Eklov, Chandrakala Pidathala, Eleanor C Row, Giuseppe Belardo, J Edward Semple, Jean-Francois Rossignol, La Frazia S, M Gabriella Santoro, Mazhar Iqbal, Neil G Berry, Paul M O'Neill, Podlogar BL, Rossignol JF, Rossignol JF, Sara Piacentini, Sarah A Allman, Simone La Frazia   +17 more
core   +1 more source

Mouse Models of Influenza Infection with Circulating Strains to Test Seasonal Vaccine Efficacy

Frontiers in Immunology, 2018
Influenza virus infection is a significant cause of morbidity and mortality worldwide. The surface antigens of influenza virus change over time blunting both naturally acquired and vaccine induced adaptive immune protection.
Helen T. Groves, Jacqueline U. McDonald, Pinky Langat, Ekaterina Kinnear, Paul Kellam, John McCauley, Joanna Ellis, Catherine Thompson, Ruth Elderfield, Lauren Parker, Wendy Barclay, John S. Tregoning   +11 more
doaj   +1 more source

Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus [PDF]

, 2014
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the reasons for its unusual severity among young adults.
A. Rambaut, Adalja, Antonovics, Davenport, Dowdle, Fan, FROST, G.-Z. Han, Kawaoka, KENDAL, M. Worobey, Masurel, Masurel, Masurel, Masurel, Molinari, Morens, Mulder, Nelson, REKART, SCHOENBAUM, Schulman, Shanks, Shanks, Taubenberger, Thompson, Thompson, Waffarn, Webster, Wolfe   +29 more
core   +2 more sources

Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle

PLoS Pathogens, 2022
Annual influenza vaccination is recommended to update the variable hemagglutinin antigens. Here, we first designed a virus-like particle (VLP) displaying consensus multi-neuraminidase (NA) subtypes (cN1, cN2, B cNA) and M2 ectodomain (M2e) tandem repeat (
Ki-hye Kim, Zhuo Li, Noopur Bhatnagar, Jeeva Subbiah, Bo Ryoung Park, C. Shin, P. Pushko, Bao-Zhong Wang, Sang-Moo Kang   +8 more
semanticscholar   +1 more source

Distribution of influenza virus types by age using case-based global surveillance data from twenty-nine countries, 1999-2014

BMC Infectious Diseases, 2018
Background Influenza disease burden varies by age and this has important public health implications. We compared the proportional distribution of different influenza virus types within age strata using surveillance data from twenty-nine countries during ...
Saverio Caini, Peter Spreeuwenberg, Gabriela F. Kusznierz, Juan Manuel Rudi, Rhonda Owen, Kate Pennington, Sonam Wangchuk, Sonam Gyeltshen, Walquiria Aparecida Ferreira de Almeida, Cláudio Maierovitch Pessanha Henriques, Richard Njouom, Marie-Astrid Vernet, Rodrigo A. Fasce, Winston Andrade, Hongjie Yu, Luzhao Feng, Juan Yang, Zhibin Peng, Jenny Lara, Alfredo Bruno, Doménica de Mora, Celina de Lozano, Maria Zambon, Richard Pebody, Leticia Castillo, Alexey W. Clara, Maria Luisa Matute, Herman Kosasih, Nurhayati, Simona Puzelli, Caterina Rizzo, Herve A. Kadjo, Coulibaly Daouda, Lyazzat Kiyanbekova, Akerke Ospanova, Joshua A. Mott, Gideon O. Emukule, Jean-Michel Heraud, Norosoa Harline Razanajatovo, Amal Barakat, Fatima el Falaki, Sue Q. Huang, Liza Lopez, Angel Balmaseda, Brechla Moreno, Ana Paula Rodrigues, Raquel Guiomar, Li Wei Ang, Vernon Jian Ming Lee, Marietjie Venter, Cheryl Cohen, Selim Badur, Meral A. Ciblak, Alla Mironenko, Olha Holubka, Joseph Bresee, Lynnette Brammer, Phuong Vu Mai Hoang, Mai Thi Quynh Le, Douglas Fleming, Clotilde El-Guerche Séblain, François Schellevis, John Paget, Global Influenza B Study group   +63 more
doaj   +1 more source

Estimating Influenza-associated Mortality in Korea: The 2009-2016 Seasons [PDF]

Journal of Preventive Medicine and Public Health, 2019
Objectives Estimating influenza-associated mortality is important since seasonal influenza affects persons of all ages, causing severe illness or death.
Kwan Hong, Sangho Sohn, Byung Chul Chun
doaj   +1 more source