Results 61 to 70 of about 32,525 (226)

Pregnant Women Have Attenuated Innate Interferon Responses to 2009 Pandemic Influenza A Virus Subtype H1N1 [PDF]

The Journal of Infectious Diseases, 2012
Pregnant women are considered to have a high risk for influenza virus infection, although little is known about the biological reasons for this risk. Antiviral immunity is critical during influenza virus infection, and understanding the changes that occur during pregnancy and the effect of vaccination is essential for improving health outcomes for ...
Forbes, Rebecca L., Wark, Peter A. B., Murphy, Vanessa E., Gibson, Peter G.   +3 more
openaire   +2 more sources

PA-X protein of H1N1 subtype influenza virus disables the nasal mucosal dendritic cells for strengthening virulence

Virulence, 2022
PA-X protein arises from a ribosomal frameshift in the PA of influenza A virus (IAV). However, the immune regulatory effect of the PA-X protein of H1N1 viruses on the nasal mucosal system remains unclear. Here, a PA-X deficient H1N1 rPR8 viral strain (rPR8-△PAX) was generated and its pathogenicity was determined.
Tao Qin, Yulian Chen, Dandan Huangfu, Yinyan Yin, Xinyu Miao, Yuncong Yin, Sujuan Chen, Daxin Peng, Xiufan Liu   +8 more
openaire   +3 more sources

The role of influenza neuraminidase transmembrane domain on budding and virus morphology [PDF]

, 2014
Influenza A virus neuraminidase (NA), a type II transmembrane glycoprotein plays a role in the cleavage of sialic acids and facilitating the release of mature virions from the surface of infected cells. NA has also previously been shown to play a role in
Roddy, Scott, Edward
core  

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Estimating the impact of influenza vaccination and antigenic drift on influenza-related morbidity and mortality in England & Wales using hidden Markov models [PDF]

Influenza causes substantial morbidity and mortality in some influenza sea- sons, especially among the elderly. Influenza seasons dominated by circula- tion of influenza A/H3N2 virus tend to result in more morbidity and mor- tality than seasons ...
Mann, Andrea Gail
core   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Pediatric hospital admissions from influenza A (H1N1) in Brazil: effects of the 2010 vaccination campaign

Clinics, 2012
lIn 2009, the influenza A (H1N1) virus spread rapidly around the world, causing the first pandemic of the 21st Century. In 2010, there was a vaccination campaign against this new virus subtype to reduce the morbidity and mortality of the disease in some ...
Ana Carolina Cavalcanti Marcos, Fernanda D'Angelo Monteiro Pelissoni, Kelly Simone Almeida Cunegundes, Marcelo Luiz Abramczyk, Nancy Cristina Junqueira Bellei, Nivea Aparecida Pissaia Sanches, Maria Isabel de Moraes-Pinto   +6 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Household Effects of School Closure during Pandemic (H1N1) 2009, Pennsylvania, USA

Emerging Infectious Diseases, 2010
To determine the effects of school closure, we surveyed 214 households after a 1-week elementary school closure because of pandemic (H1N1) 2009. Students spent 77% of the closure days at home, 69% of students visited at least 1 other location, and 79% of
Thomas L. Gift, Rakhee S. Palekar, Samir V. Sodha, Charlotte K. Kent, Ryan P. Fagan, W. Roodly Archer, Paul J. Edelson, Tiffany Marchbanks, Achuyt Bhattarai, David L. Swerdlow, Stephen Ostroff, Martin I. Meltzer   +11 more
doaj   +1 more source

Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites

Journal of Biomedical Science, 2023
Background The association between M segment splicing and pathogenicity remains ambiguous in human influenza A viruses. In this study, we aimed to investigate M splicing in various human influenza A viruses and characterize its physiological roles by ...
Yi-Ju Han, Kuo-Ming Lee, Guan-Hong Wu, Yu-Nong Gong, Avijit Dutta, Shin-Ru Shih   +5 more
doaj   +1 more source