Results 61 to 70 of about 40,863 (219)

Computational design of drug candidates for influenza A virus subtype H1N1 by inhibiting the viral neuraminidase-1 enzyme [PDF]

Acta Pharmaceutica, 2014
Abstract It is critical to seek potential alternative treatments for H1N1 infections by inhibiting neuraminidase-1 enzyme. One of the viable options for inhibiting the activity of neuraminidase- 1 is peptide drug design. In order to increase peptide stability, cyclization is necessary to prevent its digestion by protease enzyme ...
Tambunan Usman Sumo Friend, Parikesit Arli Aditya, Dephinto Yonaniko, Sipahutar Feimmy Ruth Pratiwi   +3 more
openaire   +3 more sources

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Baculovirus Displaying Hemagglutinin Elicits Broad Cross-Protection against Influenza in Mice. [PDF]

PLoS ONE, 2016
The widespread influenza virus infection further emphasizes the need for novel vaccine strategies that effectively reduce the impact of epidemic as well as pandemic influenza.
Sang-Hee Sim, Joo Young Kim, Baik Lin Seong, Huan Huu Nguyen, Jun Chang   +4 more
doaj   +1 more source

Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic. [PDF]

, 2018
Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world.
Alain Gagnon, D. Ann Herring, David J. D. Earn, Enrique Acosta, Joaquin Madrenas, Kris Inwood, Lisa Y. Dillon, Matthew S. Miller, Nadine Ouellette, Robert Bourbeau, Stacey Hallman, W. Ian Lipkin   +11 more
core   +3 more sources

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Immune protection induced on day 10 following administration of the 2009 A/H1N1 pandemic influenza vaccine. [PDF]

PLoS ONE, 2010
The 2009 swine-origin influenza virus (S-OIV) H1N1 pandemic has caused more than 18,000 deaths worldwide. Vaccines against the 2009 A/H1N1 influenza virus are useful for preventing infection and controlling the pandemic.
Yizhuo Sun, Chao Bian, Ke Xu, Weibin Hu, Tongyan Wang, Jun Cui, Hongqiang Wu, Zhiyang Ling, Yongyong Ji, Guomei Lin, Lin Tian, Yanyan Zhou, Bingnan Li, Guiyu Hu, Ning Yu, Wenqi An, Ruowen Pan, Paul Zhou, Qibin Leng, Zhong Huang, Xiaowei Ma, Bing Sun   +21 more
doaj   +1 more source

Simulations of Antigenic Variability in Influenza A [PDF]

, 2008
Computational models of the immune system (IS) and pathogenic agents have several applications, such as theory testing and validation, or as a complement to first stages of drug trials.
Agostinho C. Rosa, Nuno Fachada, Vitor V. Lopes   +2 more
core   +1 more source

A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine [PDF]

, 2017
Avian H9N2 and 2009 pandemic H1N1 (pH1N1) influenza viruses can infect pigs and humans, raising the concern that H9N2: pH1N1 reassortant viruses could emerge.
Ma, Wenjun, Mancera Gracia, José Carlos, Richt, Juergen A, Saelens, Xavier, Van den Hoecke, Silvie, Van Reeth, Kristien   +5 more
core   +2 more sources

Improved Sensitivity of a Commercial Reverse Transcription-PCR Test for Subtyping of the 2009 H1N1 Influenza A Virus [PDF]

Journal of Clinical Microbiology, 2011
Rapid detection of influenza A virus and determination of its subtype are important globally for public health surveillance and locally for the selection of antiviral treatment (1). We have used the ProFlu+ assay to test respiratory samples from children for influenza A virus, influenza B virus, and respiratory syncytial virus (RSV) and the ProFlu ST ...
Nima Mosammaparast, Richard F. Rossi, Sandra Smole, Alexander J. McAdam   +3 more
openaire   +1 more source

Identification of Clinical Factors Associated With the Immunogenicity of Homologous ChAdOx1‐nCoV‐19 Vaccine in Hemodialysis Patients

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hemodialysis (HD) patients are at higher risk of severe COVID‐19 and may exhibit suboptimal vaccine responses. This study evaluates the factors influencing vaccine‐induced immunity in HD patients following the second dose of the Vaxzevria. A total of 276 HD patients and 126 controls were included. Antibody responses were assessed using binding
Chia‐Wei Chang, Ping‐Hsun Wu, Li‐Yun Chang, Yu‐Ying Huang, Teng‐Hui Huang, Su‐Chu Lee, Yi‐wen Chiu, Shang‐Jyh Hwang, Tsun‐Yung Kuo, Mei‐Chuan Kuo   +9 more
wiley   +1 more source