Results 71 to 80 of about 114,221,800 (220)

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species [PDF]

, 2011
Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts.
García-Sastre, Adolfo, García-Sastre, A., Rong Hai, Hale Benjamin G., Pena, Lindomar, Hai, Rong, John Steel, Manicassamy Balaji, Daniel R. Pérez, Pérez Daniel R., Manicassamy, Balaji, Pena, L., Benjamin G. Hale, Sutton, T., Zsuzsanna T Varga, Troy Sutton, Sutton Troy, Varga Zsuzsanna T., Hale, B.G., Varga, Zsuzsanna T, Pena Lindomar, Zsuzsanna T. Varga, Hale, Benjamin G, Balaji Manicassamy, Adolfo García-Sastre, Schmolke, M., Hai Rong, Hai, R., Daniel R Pérez, Pérez, D.R., Sutton, Troy, Steel, John, Pérez, Daniel R, Steel, J., Steel John, García-Sastre Adolfo, Manicassamy, B., Mirco Schmolke, Lindomar Pena, Benjamin G Hale, Schmolke, Mirco, Varga, Z.T., Schmolke Mirco   +42 more
core   +2 more sources

Evolutionary Dynamics of 2009 Pandemic Influenza A Virus Subtype H1N1 in South Africa During 2009–2010 [PDF]

The Journal of Infectious Diseases, 2012
The 2009 pandemic influenza A virus subtype H1N1 (A[H1N1]pdm09) was first detected in June 2009 in South Africa and later resulted in extensive transmission throughout Africa. Established routine surveillance programs and collaboration between private and public sector laboratories allowed for comprehensive molecular epidemiological and antigenic ...
Venter, Marietjie, Naidoo, Dhamari, Pretorius, Marthi Andréa, Buys, Amelia, McAnerney, Johanna M., Blumberg, Lucille Hellen, Madhi, Shabir A., Cohen, Cheryl, Schoub, Barry D.   +8 more
openaire   +3 more sources

The comparative clinical course of pregnant and non-pregnant women hospitalised with influenza A(H1N1)pdm09 infection [PDF]

, 2012
Introduction: The Influenza Clinical Information Network (FLU-CIN) was established to gather detailed clinical and epidemiological information about patients with laboratory confirmed A(H1N1)pdm09 infection in UK hospitals.
Read, R. C., Openshaw, Peter J.M., Semple, Malcolm G., Lim Wei Shen, Semple, MG, Bannister Barbara, Taylor, B. L., Taylor Bruce L., Puja R. Myles (145227), Read Robert C., Semple, M. G., Wei Shen Lim (145243), Net, I. C. I., Semple Malcolm G., Karl G. Nicholson (145257), Myles Puja R., Bannister, Barbara, Brett, S. J., Nguyen-Van-Tam, Jonathan S., Stephen J Brett, Jonathan S. Nguyen-Van-Tam (145263), Peter J M Openshaw, Myles, PR, Barbara Bannister, Jonathan S Nguyen-Van-Tam, James McMenamin (145252), Brett, SJ, Puja R Myles, James McMenamin, Lim, W. S., Brett Stephen J., Nguyen-Van-Tam, JS, Enstone Joanne E., Karl G Nicholson, Wei Shen Lim, Enstone, Joanne E., Nicholson, Karl G., Openshaw Peter J. M., Dolan, G. P., Enstone, J. E., Robert C Read, Stephen J. Brett (145230), Brett, Stephen J., Lim, Wei Shen, McMenamin, J., Bruce L Taylor, Read, Robert C., Read, RC, Peter J. M. Openshaw (145235), McMenamin, J, Myles, Puja R., Joanne E Enstone, Dolan, Gayle P., Enstone, JE, Myles, P. R., Nicholson, KG, Gayle P. Dolan (145225), Robert C. Read (145234), Malcolm G Semple, Malcolm G. Semple (80199), Lim, WS, Taylor, BL, Nicholson, K. G., Nguyen-Van-Tam Jonathan S., McMenamin, James, Bruce L. Taylor (145248), Dolan Gayle P., Barbara Bannister (145260), Nguyen-Van-Tam, J. S., Influenza Clinical Information Network (FLU-CIN), Taylor, Bruce L., Dolan, GP, Bannister, B., Nicholson Karl G., Openshaw, P. J. M., Gayle P Dolan, McMenamin James, Openshaw, PJM, Joanne E. Enstone (145232), Bannister, B   +79 more
core   +1 more source

In Vitro and In Vivo Antiviral Activity of Nylidrin by Targeting the Hemagglutinin 2-Mediated Membrane Fusion of Influenza A Virus

Viruses, 2020
Influenza A virus, one of the major human respiratory pathogens, is responsible for annual seasonal endemics and unpredictable periodic pandemics. Despite the clinical availability of vaccines and antivirals, the antigenic diversity and drug resistance ...
Yejin Jang, Jin Soo Shin, Joo-Youn Lee, Heegwon Shin, Sang Jick Kim, Meehyein Kim   +5 more
doaj   +1 more source

Natural Reassortment of Eurasian Avian-Like Swine H1N1 and Avian H9N2 Influenza Viruses in Pigs, China

Emerging Infectious Diseases, 2022
Several zoonotic influenza A viruses detected in humans contain genes derived from avian H9N2 subtypes. We uncovered a Eurasian avian-like H1N1 swine influenza virus with polymerase basic 1 and matrix gene segments derived from the H9N2 subtype ...
Wanying Sun, Samuel S.M. Cheng, Kristy N.T. Lam, Tsz C. Kwan, Ricky W.K. Wong, Leo H.K. Lau, Gigi Y.Z. Liu, Leo L.H. Luk, John K.C. Li, Haogao Gu, Malik Peiris, Leo L.M. Poon   +11 more
doaj   +1 more source

Some Exposure for Influenza Hemagglutinin Interface Antibodies

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Influenza viruses are a constant threat to human health. Current vaccines often confer low to moderate protection against infection with seasonal viruses and little‐to‐no protection against pandemic viruses. Improved vaccines are needed. These vaccines will need to reliably elicit antibodies to conserved sites that are broadly protective.
Kevin R. McCarthy
wiley   +1 more source

Pregnant Women Have Attenuated Innate Interferon Responses to 2009 Pandemic Influenza A Virus Subtype H1N1 [PDF]

The Journal of Infectious Diseases, 2012
Pregnant women are considered to have a high risk for influenza virus infection, although little is known about the biological reasons for this risk. Antiviral immunity is critical during influenza virus infection, and understanding the changes that occur during pregnancy and the effect of vaccination is essential for improving health outcomes for ...
Forbes, Rebecca L., Wark, Peter A. B., Murphy, Vanessa E., Gibson, Peter G.   +3 more
openaire   +2 more sources

Respiratory and systematic humoral and cellular immune response of pigs to a heterosubtypic influenza A virus infection [PDF]

, 2001
The level of heterosubtypic immunity (Het-I) and the immune mechanisms stimulated by a heterosubtypic influenza virus infection were investigated in pigs. Pigs are natural hosts for influenza virus and, like humans, they host both subtypes H1N1 and H3N2.
Heinen, P.P., de Boer Luijtze, E.A., Boer Luijtze, E.A., de, Bianchi, A.T.J.   +3 more
core  

Use of cumulative incidence of novel influenza A/H1N1 in foreign travelers to estimate lower bounds on cumulative incidence in Mexico [PDF]

, 2009
Background: An accurate estimate of the total number of cases and severity of illness of an emerging infectious disease is required both to define the burden of the epidemic and to determine the severity of disease. When a novel pathogen first appears,
Dowell, Scott F., Lipsitch Marc, Miller, Joel, O'Hagan, JJ, Reed, C, Wallinga Jacco, Jacco Wallinga, Scott F Dowell, Goldstein, E, O'Hagan Justin J., Ted Cohen, Goldstein Edward, Lajous, M, Carrie Reed, Riley, Steven, Riley Steven, Reed, Carrie, Justin J O'Hagan, Lipsitch, M, Lajous, Martin, McCarron Meg, Danon, Leon, Dowell, SF, McCarron, Meg, Cohen, T, Leon Danon, Meg McCarron, Lipsitch, Marc, Reed Carrie, Cohen Ted, O'Hagan, Justin, Danon, L, Miller Joel C., Dowell, Scott, Miller, Joel C., Lajous Martin, Goldstein, Edward, Wallinga, J, Danon Leon, Miller, JC, Wallinga, Jacco, McCarron, M, O'Hagan, Justin J., Dowell Scott F., Edward Goldstein, Steven Riley, Riley, S, Martin Lajous, Marc Lipsitch, Joel C Miller, Cohen, Ted   +50 more
core   +1 more source