Results 181 to 190 of about 25,700 (224)

Understanding of Drug-Target Interactions: A case Study in Influenza Virus A Subtype H5N1

AIP Conference Proceedings, 2007
This study aims at gaining insight into molecular mechanisms of action of three drug targets of the life cycle of influenza virus A subtype H5N1, namely Hemagglutinin (H5), Neuraminidase (N1) and M2 ion channel (M2), using molecular mechanics and molecular dynamics techniques.
Thanyada Rungrotmongkol, Maturos Malaisree, Panita Decha, Chittima Laohpongspaisan, Ornjira Aruksakunwong, Pathumwadee Intharathep, Somsak Pianwanit, Pornthep Sompornpisut, Vudhichai Parasuk, Eugene Megnassan, Vladimir Frecer, Stanislav Miertus, Supot Hannongbua, Theodore E. Simos, George Maroulis   +14 more
openaire   +1 more source

Characterisation and haemagglutinin gene epitope mapping of a variant strain of H5N1 subtype avian influenza virus

Veterinary Microbiology, 2013
H5N1 avian influenza virus (AIV) undergoes rapid evolution, and its antigenicity needs to be constantly evaluated in order to update the vaccine strain. In this report, a clade 7.2 AIV isolate named A/Chicken/Huadong/4/2008 (DT) is identified. Antigenic analysis revealed that DT had a significant low cross-reactive HI titre with antiserum against a ...
Yanfang, Li, Xiaojian, Zhang, Quangang, Xu, Qiang, Fu, Yinbiao, Zhu, Sujuan, Chen, Daxin, Peng, Xiufan, Liu   +7 more
openaire   +2 more sources

Simultaneous detection of influenza virus type B and influenza A virus subtypes H1N1, H3N2, and H5N1 using multiplex real-time RT-PCR

Applied Microbiology and Biotechnology, 2011
Use of multiplex real-time reverse transcription polymerase chain reaction (RT-PCR) for the simultaneous detection of influenza type B virus and influenza A virus subtypes H5N1, H3N2, and H1N1 has been described. The method exhibited a high specificity and sensitivity of approximately 10(1)-10(2) copies per microliter or 10(-3)-10(-2) TCID50/L for each
Fang, Shisong, Li, Jianxiong, Cheng, Xiaowen, Zhao, Cunyou, Wang, Ting, Lv, Xing, Wang, Xin, Wu, Chunli, Zhang, Renli, Cheng, Jinquan, Hong, Xue, Yu, Muhua   +11 more
openaire   +3 more sources

Single-Step Multiplex Reverse Transcription–Polymerase Chain Reaction (RT-PCR) for Influenza A Virus Subtype H5N1 Detection

Viral Immunology, 2004
Influenza A virus subtype H5N1 causes a rapidly fatal systemic disease in domestic poultry and spreads directly from poultry to humans. The aim of this study was to develop a rapid, cost-saving and effective method for influenza A virus subtype H5N1 detection.
Sunchai, Payungporn, Piraya, Phakdeewirot, Salin, Chutinimitkul, Apiradee, Theamboonlers, Juthatip, Keawcharoen, Kanisak, Oraveerakul, Alongkorn, Amonsin, Yong, Poovorawan   +7 more
openaire   +2 more sources

Prepandemic Influenza Vaccine H5N1 (Split Virion, Inactivated, Adjuvanted) [Prepandrix™]

BioDrugs, 2008
Although rare, influenza pandemics are a recurrent event, and influenza A/H5N1 is generally considered to be the most likely causative agent of the next pandemic. Vaccines are widely considered to be the first line of defense for protecting populations in advance of an influenza pandemic.
Natalie J, Carter, Greg L, Plosker
openaire   +2 more sources

Encephalitis in a Stone Marten (Martes foina) after Natural Infection with Highly Pathogenic Avian Influenza Virus Subtype H5N1

Journal of Comparative Pathology, 2007
Recent outbreaks of disease in different avian species, caused by the highly pathogenic avian influenza virus (HPAIV), have involved infection by subtype H5N1 of the virus. This virus has also crossed species barriers and infected felines and humans.
R, Klopfleisch, P U, Wolf, C, Wolf, T, Harder, E, Starick, M, Niebuhr, T C, Mettenleiter, J P, Teifke   +7 more
openaire   +2 more sources

Human single-chain antibodies that neutralize homologous and heterologous strains and clades of influenza a virus subtype H5N1

Antiviral Therapy, 2008
Background Human antibodies that interfere with the biological activity of haemagglutinins (HAs) of influenza viruses have high potential as an antiviral agent. Methods Human single-chain antibody fragments (HuScFv) to recombinant and native HAs of the influenza virus H5N1 subtype were produced using a human antibody phage display library with the ...
Santi, Maneewatch, Jeeraphong, Thanongsaksrikul, Thaweesak, Songserm, Kanyarat, Thueng-In, Kasem, Kulkeaw, Umaporn, Thathaisong, Potjanee, Srimanote, Pongsri, Tongtawe, Pramuan, Tapchaisri, Wanpen, Chaicumpa   +9 more
openaire   +2 more sources

Isolation and characterization of influenza A virus (subtype H5N1) that caused the first highly pathogenic avian influenza outbreak in chicken in Bhutan

Veterinary Microbiology, 2012
We characterized Influenza A/H5N1 virus that caused the first outbreak of highly pathogenic avian influenza (HPAI) in chickens in Bhutan in 2010. The virus was highly virulent to chicken, killing them within two days of the experimental inoculation with an intravenous pathogenicity index (IVPI) of 2.88.
S C, Dubey, N, Dahal, S, Nagarajan, C, Tosh, H V, Murugkar, K, Rinzin, B, Sharma, R, Jain, M, Katare, S, Patil, R, Khandia, Z, Syed, S, Tripathi, P, Behera, M, Kumar, D D, Kulkarni, Lal, Krishna   +16 more
openaire   +2 more sources

Rapid Detection of Avian Influenza Virus A and Subtype H5N1 by Single Step Multiplex Reverse Transcription-polymerase Chain Reaction

Virus Genes, 2006
Outbreaks of H5N1 highly pathogenic avian influenza (HPAI) virus caused great economic losses to the poultry industry and resulted in human deaths in Thailand and Viet Nam in 2004. Rapid typing and subtyping of H5N1 viruses, especially from clinical specimens, are desirable for taking prompt control measures to prevent the spread of the disease.
Hui-Ling, Wei, Gui-Rong, Bai, Aaron S, Mweene, Ying-Chun, Zhou, Yan-Long, Cong, Juan, Pu, Shuai, Wang, Hiroshi, Kida, Jin-Hua, Liu   +8 more
openaire   +2 more sources

Comparison of neuraminidase activity of influenza A virus subtype H5N1 and H1N1 using reverse genetics virus.

The Southeast Asian journal of tropical medicine and public health, 2010
Neuraminidase (NA) is an envelope surface glycoprotein of influenza A viruses. It cleaves alpha-(2,3) or alpha-(2,6) glycosidic linkage between a terminal sialic acid residue of the host cell receptor and hemagglutinin of the viral envelope, thus releasing viral progeny from the infected cell.
Anchalee, Rawangkhan, Donruedee, Sanguansermsri, Narutchala, Suwannakhon, Sutatip, Pongcharoen, Purinthra, Pensuwan, Chanpen, Chamnanpood, Pornchai, Chamnanpood, Phanchana, Sanguansermsri   +7 more
openaire   +1 more source