Results 191 to 200 of about 20,121 (221)

Understanding of Drug-Target Interactions: A case Study in Influenza Virus A Subtype H5N1

AIP Conference Proceedings, 2007
This study aims at gaining insight into molecular mechanisms of action of three drug targets of the life cycle of influenza virus A subtype H5N1, namely Hemagglutinin (H5), Neuraminidase (N1) and M2 ion channel (M2), using molecular mechanics and molecular dynamics techniques.
Thanyada Rungrotmongkol, Maturos Malaisree, Panita Decha, Chittima Laohpongspaisan, Ornjira Aruksakunwong, Pathumwadee Intharathep, Somsak Pianwanit, Pornthep Sompornpisut, Vudhichai Parasuk, Eugene Megnassan, Vladimir Frecer, Stanislav Miertus, Supot Hannongbua, Theodore E. Simos, George Maroulis   +14 more
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Characterisation and haemagglutinin gene epitope mapping of a variant strain of H5N1 subtype avian influenza virus

Veterinary Microbiology, 2013
H5N1 avian influenza virus (AIV) undergoes rapid evolution, and its antigenicity needs to be constantly evaluated in order to update the vaccine strain. In this report, a clade 7.2 AIV isolate named A/Chicken/Huadong/4/2008 (DT) is identified. Antigenic analysis revealed that DT had a significant low cross-reactive HI titre with antiserum against a ...
Yanfang, Li, Xiaojian, Zhang, Quangang, Xu, Qiang, Fu, Yinbiao, Zhu, Sujuan, Chen, Daxin, Peng, Xiufan, Liu   +7 more
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Susceptibility and transmissibility of pigeons to Asian lineage highly pathogenic avian influenza virus subtype H5N1

Avian Pathology, 2007
To determine whether or not pigeons are susceptible to infection with Asian lineage highly pathogenic (HP) avian influenza virus (AIV) subtype H5N1 and can serve as a transmission host for H5N1 HPAIV, we experimentally infected 187 young and adult pigeons with five different isolates of H5N1 HPAIV and co-habited some experimentally infected pigeons ...
Yuehuan, Liu, Jiao, Zhou, Hanchun, Yang, Weiguang, Yao, Weidong, Bu, Bing, Yang, Weiping, Song, Yanni, Meng, Jian, Lin, Chunhua, Han, Junjie, Zhu, Zhijun, Ma, Jingyi, Zhao, Xiuqing, Wang   +13 more
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Isolation and Identification of Highly Pathogenic Avian Influenza Virus Subtype H5N1 in Peafowl (Pavo cristatus)

Avian Diseases Digest, 2010
An outbreak of highly pathogenic avian influenza (HPAI) virus subtype H5N1 was first diagnosed in a "backyard" flock of peafowl (Pavo cristatus) raised on palace premises in the Kingdom of Saudi Arabia in December 3, 2007. The flock consisted of 40 peafowl, and their ages ranged from 3 to 5 years old.
Mahmoud Moussa, Ismail, Owais Ahmed, Khan, Giovanni, Cattoli, Huaguang, Lu   +3 more
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[In vitro study of antiviral activity of Myramistin against subtypes H3N2 and H5N1 of influenza virus].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2009
In vitro antiviral effect of myramistin on influenza virus (MDCK cell culture) was studied. The drug showed significant dose-dependent antiviral activity against the virus. When used prophylactically (1 hour before exposure to the virus) in subtoxic doses, myramistin was effective in inhibiting replication of the influenza virus [strains A/Aichi/2/68 ...
A P, Agafonov, M O, Skarnovich, V A, Petrishchenko, L N, Shishkina, A N, Sergeev, V V, Svistov, I V, Smirnov, N A, Kirichenko, Iu S, Krivoshein   +8 more
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Simultaneous detection of influenza virus type B and influenza A virus subtypes H1N1, H3N2, and H5N1 using multiplex real-time RT-PCR

Applied Microbiology and Biotechnology, 2011
Use of multiplex real-time reverse transcription polymerase chain reaction (RT-PCR) for the simultaneous detection of influenza type B virus and influenza A virus subtypes H5N1, H3N2, and H1N1 has been described. The method exhibited a high specificity and sensitivity of approximately 10(1)-10(2) copies per microliter or 10(-3)-10(-2) TCID50/L for each
Fang, Shisong, Li, Jianxiong, Cheng, Xiaowen, Zhao, Cunyou, Wang, Ting, Lv, Xing, Wang, Xin, Wu, Chunli, Zhang, Renli, Cheng, Jinquan, Hong, Xue, Yu, Muhua   +11 more
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Comparison of neuraminidase activity of influenza A virus subtype H5N1 and H1N1 using reverse genetics virus.

The Southeast Asian journal of tropical medicine and public health, 2010
Neuraminidase (NA) is an envelope surface glycoprotein of influenza A viruses. It cleaves alpha-(2,3) or alpha-(2,6) glycosidic linkage between a terminal sialic acid residue of the host cell receptor and hemagglutinin of the viral envelope, thus releasing viral progeny from the infected cell.
Anchalee, Rawangkhan, Donruedee, Sanguansermsri, Narutchala, Suwannakhon, Sutatip, Pongcharoen, Purinthra, Pensuwan, Chanpen, Chamnanpood, Pornchai, Chamnanpood, Phanchana, Sanguansermsri   +7 more
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[Characterization of murine leukemia virus recombinants that express H5N1 subtype avian influenza virus hemagglutinin glycoproteins].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2009
One highly pathogenic strain of avian influenza virus (AIV) was isolated from goose in China recently, designated as F-3. In order to study the viral entry mechanisms, the hemagglutinin (HA) gene of H5N1 subtype AIV isolate was amplified by RT-PCR, and then cloned into pGEM-T vector and sequenced.
Hua-Lei, Liu, Li-Jun, Rong, Bin, Zhou, Jian-Chao, Wei, Qi-Sheng, Zheng, Pu-Yani, Chen   +5 more
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Development of a recombinant fowlpox virus vector-based vaccine of H5N1 subtype avian influenza.

Developments in biologicals, 2006
The genetic stability of the recombinant fowlpox virus (named rFPV-HA-NA) was confirmed by serial passage on chicken embryo fibroblast (CEF) cells. The immune efficacy, safety, the minimum immunising dose, the time of immunity induced and the immune duration of the vector-based vaccine was evaluated in specific-pathogen-free (SPF) chickens.
C, Qiao, K, Yu, Y, Jiang, C, Li, G, Tian, X, Wang, H, Chen   +6 more
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[Generation of attenuated H5N1 and H5N2 subtypes of influenza virus recombinants by reverse genetics system].

Wei sheng wu xue bao = Acta microbiologica Sinica, 2006
The HA connecting peptide at cleavage site, PQRERRKKR / GL, of an H5N1 subtype avian influenza virus (AIV) was replaced with PQRESR / GL, and then the modified HA gene was cloned into the transcription/expression vector, pHW2000, constructing a plasmid named pHW524-HA. The NA (N1) gene from the H5N1 virus and the NA (N2) gene from an H9N2 AIV were also
Jian-hong, Lu, Jin-xue, Long, Wei-xing, Shao, Dong-ping, Wei, Xiu-fan, Liu   +4 more
openaire   +1 more source