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Development of a recombinant fowlpox virus vector-based vaccine of H5N1 subtype avian influenza.
Developments in biologicals, 2006The genetic stability of the recombinant fowlpox virus (named rFPV-HA-NA) was confirmed by serial passage on chicken embryo fibroblast (CEF) cells. The immune efficacy, safety, the minimum immunising dose, the time of immunity induced and the immune duration of the vector-based vaccine was evaluated in specific-pathogen-free (SPF) chickens.
C, Qiao +6 more
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Avian Pathology, 2010
The recent epidemic caused by H5N1 highly pathogenic avian influenza (HPAI) viruses has spread over many parts of Asia, Europe and Africa. Wild birds, particularly waterfowl, are considered to play a role in viral dissemination. However, detailed information on whether wild terrestrial birds act as carriers is currently unavailable.
Yoshikazu, Fujimoto +10 more
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The recent epidemic caused by H5N1 highly pathogenic avian influenza (HPAI) viruses has spread over many parts of Asia, Europe and Africa. Wild birds, particularly waterfowl, are considered to play a role in viral dissemination. However, detailed information on whether wild terrestrial birds act as carriers is currently unavailable.
Yoshikazu, Fujimoto +10 more
openaire +2 more sources
Journal of Chemical Information and Modeling, 2009
The outbreak of avian influenza A subtype H5N1 virus has raised a global concern for both animal as well as human health. Recently, drug resistance in H5N1 infections has been widely reported due to neuraminidase mutations. Consequently, the understanding of inhibitor-neuraminidase interactions at the molecular level represents the main goal of our ...
Thanyarat, Udommaneethanakit +4 more
openaire +2 more sources
The outbreak of avian influenza A subtype H5N1 virus has raised a global concern for both animal as well as human health. Recently, drug resistance in H5N1 infections has been widely reported due to neuraminidase mutations. Consequently, the understanding of inhibitor-neuraminidase interactions at the molecular level represents the main goal of our ...
Thanyarat, Udommaneethanakit +4 more
openaire +2 more sources
Canadian Journal of Microbiology, 2007
To investigate the genomic patterns of influenza A virus subtypes, such as H3N2, H9N2, and H5N1, we collected 1842 sequences of the hemagglutinin and neuraminidase genes from the NCBI database and parsed them into 7 categories: accession number, host species, sampling year, country, subtype, gene name, and sequence.
Insung, Ahn, Hyeon S, Son
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To investigate the genomic patterns of influenza A virus subtypes, such as H3N2, H9N2, and H5N1, we collected 1842 sequences of the hemagglutinin and neuraminidase genes from the NCBI database and parsed them into 7 categories: accession number, host species, sampling year, country, subtype, gene name, and sequence.
Insung, Ahn, Hyeon S, Son
openaire +2 more sources
Molecular Biology Reports, 2009
The conserved M2 protein of influenza A virus is considered as a promising candidate target for a broad-spectrum, recombinant influenza A vaccine. In the present study, the open reading frame (ORF) of avian influenza A/chicken/Iran/101/1998 (H9N2) M2 gene was amplified then cloned in pAED4, prokaryotic expression vector. M2 protein was produced through
Seyyed Mahmoud, Ebrahimi +4 more
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The conserved M2 protein of influenza A virus is considered as a promising candidate target for a broad-spectrum, recombinant influenza A vaccine. In the present study, the open reading frame (ORF) of avian influenza A/chicken/Iran/101/1998 (H9N2) M2 gene was amplified then cloned in pAED4, prokaryotic expression vector. M2 protein was produced through
Seyyed Mahmoud, Ebrahimi +4 more
openaire +2 more sources
2014
The Spanish flu first occurred in 1918 and killed about 50 million people in the world. In 2005, by using gene decoding process, Robert B. Belshe identified that the Spanish flu was occurred by H1N1, which is highly pathogenic influenza A virus. Influenza A virus has been mutated consistently and unexpectedly; H5N1, H5N2, and H7N9 which used to be ...
Dae Young Kim +3 more
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The Spanish flu first occurred in 1918 and killed about 50 million people in the world. In 2005, by using gene decoding process, Robert B. Belshe identified that the Spanish flu was occurred by H1N1, which is highly pathogenic influenza A virus. Influenza A virus has been mutated consistently and unexpectedly; H5N1, H5N2, and H7N9 which used to be ...
Dae Young Kim +3 more
openaire +1 more source
Bing du xue bao = Chinese journal of virology, 2010
Abstract:One H5N1 subtype avian influenza virus, A/duck/Shandong/009/2008 (Dk/SD/009/08), was isolated from apparently healthy domestic ducks in some live bird market in East China during our epidemiological surveillance. To investigate the genetic composition, Dk/SD/009/08 was subjected to genome sequencing.
Min, Gu +6 more
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Abstract:One H5N1 subtype avian influenza virus, A/duck/Shandong/009/2008 (Dk/SD/009/08), was isolated from apparently healthy domestic ducks in some live bird market in East China during our epidemiological surveillance. To investigate the genetic composition, Dk/SD/009/08 was subjected to genome sequencing.
Min, Gu +6 more
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Co-evolution of immunity and seasonal influenza viruses
Nature Reviews Microbiology, 2023Alvin X Han, Colin A Russell
exaly
Influenza lineage extinction during the COVID-19 pandemic?
Nature Reviews Microbiology, 2021Marios Koutsakos +2 more
exaly
Next-generation influenza vaccines: opportunities and challenges
Nature Reviews Drug Discovery, 2020Chih-Jen Wei +2 more
exaly