Results 121 to 130 of about 114,480,210 (307)

Targeting Hemagglutinin: Approaches for Broad Protection against the Influenza A Virus

Viruses, 2019
Influenza A viruses are dynamically epidemic and genetically diverse. Due to the antigenic drift and shift of the virus, seasonal vaccines are required to be reformulated annually to match with current circulating strains.
Yun Zhang, Cong Xu, Hao Zhang, George Dacai Liu, Chunyi Xue, Yongchang Cao   +5 more
doaj   +1 more source

THE SIZE OF INFLUENZA VIRUS [PDF]

Journal of Experimental Medicine, 1944
The sedimentation behavior of influenza virus in dilute solutions of electrolyte was found to be quite variable. At times the virus activity appeared to sediment at a rate comparable with that of particles about 80 to 120 mµ in diameter, at other times at a rate comparable with that of particles about 10 mµ in diameter, and at still other times the ...
openaire   +2 more sources

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Intra- and interspecies transmission of H7N7 highly pathogenic avian influenza virus during the avian influenza epidemic in the Netherlands in 2003 [PDF]

, 2009
The poultry epidemic of H7N7 highly pathogenic avian influenza (HPAI) virus in the Netherlands in 2003 was probably the result of the introduction of an H7N7 low pathogenic avian influenza (LPAI) virus (by interspecies transmission from wild birds) and ...
Goot, J.A., van der, Stegeman, J.A., Jong, M.C.M., de, Koch, G.   +3 more
core  

The multifunctional NS1 protein of influenza A viruses [PDF]

, 2008
The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor that has multiple accessory functions during viral infection.
Hale, Benjamin Geoffrey, Hale, B.G., Ortin, J., Jackson, D., Randall, Richard Edward, Randall, R.E., Jackson, David, Ortin, J   +7 more
core   +1 more source

Risk of Swine Influenza Virus Spillover at the Human-Swine Interface – a Scoping Review

International Journal of Public Health
ObjectivesWe conducted this scoping review to describe the factors that influence the risk of spillover of Swine Influenza Virus (SIV) at various human-swine interfaces.MethodsWe used the PubMed and EMBASE databases to identify relevant articles ...
Sendhilkumar Muthappan, Rizwan Suliankatchi Abdulkader, Gulam Mohd, Jasmine Beryl Lydia, Janana Priya, Anusha Salvankar, Pujitha Mallina, Vineetha Varanasi, Manickam Ponnaiah, Subarna Roy, Manoj V. Murhekar   +10 more
doaj   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export [PDF]

, 2014
This work is supported by grants from the Wellcome Trust (grants 087751/A/08/Z) and MRC (G1001726/1).We have examined the requirements for virus transcription and replication and thus the roles of input and progeny genomes in the generation of interferon
Randall, Richard E, Smith, Matt, Killip, Marian J, Jackson, David   +3 more
core   +1 more source

Identification of Novel and Efficacious Chemical Compounds that Disturb Influenza A Virus Entry in vitro

Frontiers in Cellular and Infection Microbiology, 2017
Influenza A virus is a negative RNA stranded virus of the family Orthomyxoviridae, and represents a major public health threat, compounding existing disease conditions.
Hany Khalil, Tamer El Malah, Ahmed I. Abd El Maksoud, Ibrahim El Halfawy, Ahmed A. El Rashedy, Mahmoud El Hefnawy   +5 more
doaj   +1 more source

Avian influenza virus

Uirusu, 2004
Recent outbreaks of highly pathogenic avian influenza in chickens and ducks that occurred in 9 Asian countries including Japan alarmed to realize that there is no border for infections and gave a rise to great concern for human health as well as for agriculture. This H5N1 virus jumped the species barrier and caused severe disease with high mortality in
openaire   +3 more sources