Results 141 to 150 of about 114,480,210 (307)

Human Co-Infection with Avian and Seasonal Influenza Viruses, China

Emerging Infectious Diseases, 2014
Jun Li, Yu Kou, Xinfen Yu, Yongxiang Sun, Yinyan Zhou, Xiaoying Pu, Tao Jin, Jingcao Pan, George F. Gao   +8 more
doaj   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

Advanced Science, EarlyView.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen, Ming‐Ying Xiao, Lan‐Lan Guo, Hao‐Yue Hu, Sui‐Xian Zhang, Bai‐Qiang Dong, Chen‐Fei Wu, Xia‐Hang Huang, Li Li, Run‐Zhe Chen, Yuan‐Yang Huang, Ying Jin, Hai Song, Ying Wang, Qi‐Wen Li, Ming Chen, Xuan Li, Yuan‐Yuan Chen   +17 more
wiley   +1 more source

What Consumers Need to Know about Bird Flu (Influenza H5N1)

EDIS
Bird flu is caused by the H5N1 subtype of influenza A virus. This publication aims to help consumers better understand bird flu and ways bird flu may impact consumable products, such as eggs or milk. Written by A. McLeod-Morin, B. D. Anderson, G. Morris,
Ashley McLeod-Morin, Benjamin Anderson, Glenn Morris, Cynthia Sanders, Colleen Larson, Ricky Telg, Annabel Henson   +6 more
doaj   +3 more sources

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Serological response to avian influenza viruses among occupationally exposed population in Taiwan, a longitudinal cohort study, 2021–2023

Journal of the Formosan Medical Association
The Taiwan Centers for Disease Control (TCDC) initiated longitudinal sero-epidemiological surveillance of avian influenza viruses (AIVs) targeting poultry workers exposed on affected farms since 2021.
Tsung-Pei Tsou, Chieh-Yu Lin, Shu-Er Yang, Hui-Tzu Wang, I-Ling Yu, Ming-Tsan Liu, Yi-Chien Chih   +6 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Cross-reactive human antibody responses to H9N2 influenza virus, New York, United States, 2025

Eurosurveillance
Understanding population immunity to emerging viruses is critical for risk assessment. We characterised antibody responses to avian influenza A(H9N2) viruses in 298 human sera from adults in New York City. We observed widespread cross-reactive H9-binding
Florian Krammer
doaj   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Influenza Virus [PDF]

Transfusion Medicine and Hemotherapy, 2009
openaire   +2 more sources