Results 241 to 250 of about 2,843,834 (270)

Process intensification of the baculovirus expression vector system using a perfusion process with a low multiplicity of infection at high cell concentrations

open access: yesBiotechnology Progress, EarlyView.
Abstract The emergence of new viruses and the spread of existing pathogens necessitate efficient vaccine production methods. The baculovirus expression vector system (BEVS) is an efficient and scalable system for subunit and virus‐like particle vaccine production and gene therapy vectors.
Jort J. Altenburg   +7 more
wiley   +1 more source

A method for facile production of variable lymphocyte receptors using SHuffle Escherichia coli

open access: yesBiotechnology Progress, EarlyView.
Abstract Variable lymphocyte receptors (VLRs) are the antigen receptors of jawless vertebrates such as lamprey. VLRs are of growing biotechnological interest for their ability to bind certain antigenic targets with higher affinity than traditional immunoglobulins.
Elizabeth A. Appelt   +9 more
wiley   +1 more source

Influenza a virus antiparallel helical nucleocapsid-like pseudo-atomic structure. [PDF]

open access: yesNucleic Acids Res
Chenavier F   +7 more
europepmc   +1 more source

Continuous purification of a parvovirus using two aqueous two‐phase extraction steps

open access: yesBiotechnology Progress, EarlyView.
Abstract Aqueous two‐phase systems (ATPS) are a liquid–liquid extraction method that offers low‐cost, continuous‐adaptable virus purification. A two‐step ATPS using polyethylene glycol (PEG) and sodium citrate that recovered 66% of infectious porcine parvovirus with 2.0 logs of protein removal and 1.0 logs of DNA removal in batch has now been run ...
Natalie M. Nold   +11 more
wiley   +1 more source

Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

open access: yesCancer Communications, EarlyView.
Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grade serous ovarian cancer (HGSOC), but the underlying ...
Chenyang Wang   +11 more
wiley   +1 more source

Chemical composition, antioxidant, antimicrobial, antidiabetic and butyrylcholinesterase inhibitory activities in vitro of the essential oil and crude extracts of the aerial parts of Thymus ciliatus

open access: yesChemistry &Biodiversity, Accepted Article.
This study explores the potential of Thymus ciliatus as a natural source of bioactive compounds by investigating its chemical composition and in vitro biological activities, including antioxidant, antimicrobial, antidiabetic, and anti‐Alzheimer properties. The analysis of the essential oil was performed using GC‐MS revealing α‐terpinenyl acetate (18.74%
Nadia Djermane   +8 more
wiley   +1 more source

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