Results 251 to 260 of about 114,480,210 (307)

3-Amidinophenylalanine-Derived Inhibitors' Antiviral Effect Against H1N1 Influenza A Virus. [PDF]

Antibiotics (Basel)
Tóth L, Marosi A, Schmacke LC, Steinmetzer T, Rácz A, Bajusz D, Jerzsele Á, Kunsági-Máté S, Poór M, Pászti-Gere E.   +9 more
europepmc   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

SNX-BAR proteins 5 and 6 are required for NCOA7-AS antiviral activity against influenza A virus. [PDF]

J Biol Chem
Arnaud-Arnould M, Rebendenne A, Tauziet M, Urbach S, El Koulali K, Ricci EP, Wencker M, Moncorgé O, Blaise M, Goujon C.   +9 more
europepmc   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

The impact of viral and host factors on the influenza A virus transmission bottleneck. [PDF]

PLoS Pathog
Krupinsky KC, Bendall EE, Zhu Y, Stockwell MS, Nguyen HQ, Meece JK, Maldonado Y, Ellingson KD, Lutrick K, Asturias EJ, Rao S, Bowman NM, Rolfes M, Biddle JE, Mellis A, Schmitz JE, Chappell JD, Halasa NB, Fitzsimmons WJ, Martin ET, Grijalva CG, Talbot HK, Lauring AS.   +22 more
europepmc   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Bacterial alteration of redox stressors impacts environmental stability of influenza A virus. [PDF]

mSphere
Williams MR, Rowe HM.
europepmc   +1 more source

A Novel Sparse Cellular Labeling System with Tunable Gradients and Long‐Term Stability

Advanced Science, EarlyView.
The Tri‐M (Multi‐recombinase, Multi‐recognition site, and Multi‐nested) sparse cellular labeling system, built upon competitive recombination, integrates transgenic mice with viral injection to achieve tunable and long‐term stable sparse labeling of specific cell types with region selectivity, from sparse populations to individual cells, facilitating ...
Xiaomei Tang, Zhenye Hou, Li Lu, Yige Song, Changdong Chai, Lanfang Li, Yuhang Shen, Shuo Wang, Ya Zhao, Jinyu Zeng, Yiqing Guo, Fuliang Jiang, Zhigao Xiang, Hao Li, Aodi He, Bing Zhang, Youming Lu, Xinyan Li   +17 more
wiley   +1 more source

Attenuation of Influenza a Virus into Live Vaccines Through C-End Degrons. [PDF]

Adv Sci (Weinh)
Wang P, Li L, Chen Y, Tong L, Li Z, Yu R, Shen Q, Wang Q, Hou J, Zhang Q, Si X, Wang N, Zhou D, Tian WX, Si L.   +14 more
europepmc   +1 more source

Delactylation of viral proteins by SIRT1 suppresses influenza A virus replication. [PDF]

mBio
Chen D, Zhao G, Zhou J, Sun P, He S, Lv C, Chen Y, Zhu S, Gao M, Guo G.   +9 more
europepmc   +1 more source