Results 31 to 40 of about 945,008 (390)

TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes

Journal of Virology, 2019
Influenza A viruses (IAV) and influenza B viruses (IBV) cause significant morbidity and mortality during seasonal outbreaks. Cleavage of the viral surface glycoprotein hemagglutinin (HA) by host proteases is a prerequisite for membrane fusion and ...
H. Limburg, Anne Harbig, Dorothea Bestle, D. A. Stein, H. Moulton, J. Jaeger, Harshavardhan Janga, Kornelia Hardes, J. Koepke, Leon N. Schulte, A. Koczulla, B. Schmeck, H. Klenk, E. Böttcher-Friebertshäuser   +13 more
semanticscholar   +1 more source

Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Wild Birds, Chile

Emerging Infectious Diseases, 2023
In December 2022, highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus emerged in Chile. We detected H5N1 virus in 93 samples and obtained 9 whole-genome sequences of strains from wild birds.
Naomi Ariyama, Catalina Pardo-Roa, Gabriela Muñoz, Carolina Aguayo, Claudia Ávila, Christian Mathieu, Leonardo I. Almonacid, Rafael A. Medina, Barbara Brito, Magdalena Johow, Victor Neira   +10 more
doaj   +1 more source

Evolution of Influenza A Virus by Mutation and Re-Assortment

International Journal of Molecular Sciences, 2017
Influenza A virus (IAV), a highly infectious respiratory pathogen, has continued to be a significant threat to global public health. To complete their life cycle, influenza viruses have evolved multiple strategies to interact with a host.
Wenhan Shao, Xinxin Li, M. U. Goraya, Song-Liang Wang, Jilong Chen   +4 more
semanticscholar   +1 more source

Human-Origin Influenza A(H3N2) Reassortant Viruses in Swine, Southeast Mexico

Emerging Infectious Diseases, 2019
The genetic diversity of influenza A viruses circulating in swine in Mexico complicates control efforts in animals and presents a threat to humans, as shown by influenza A(H1N1)pdm09 virus. To describe evolution of swine influenza A viruses in Mexico and
Martha I. Nelson, Carine K. Souza, Nídia S. Trovão, Andres Diaz, Ignacio Mena, Albert Rovira, Amy L. Vincent, Montserrat Torremorell, Douglas Marthaler, Marie R. Culhane   +9 more
doaj   +1 more source

Canalization of the evolutionary trajectory of the human influenza virus [PDF]

, 2011
Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. Antigenic evolution occurs in the context of a two-dimensional 'antigenic map', while genetic evolution shows a characteristic ladder-like ...
A Kucharski, A Monto, A Park, A Rambaut, Andrew Rambaut, B Adams, B Finkelman, C Viboud, CA Russell, D Weinreich, DJ Smith, E Goldstein, E O'Dea, E Volz, F Carrat, F Tria, G Chowell, G Hirst, IG Barr, J Gog, J Lin, J O'Brien, J Truscott, J Voeten, K Koelle, K Koelle, K Koelle, K Koelle, M Recker, Mercedes Pascual, MI Nelson, NM Ferguson, R Bush, S Bhatt, S Gould, S Kryazhimskiy, S Park, T Bedford, T Bedford, Trevor Bedford, V Gupta, WM Fitch, YI Wolf, Z Yang   +43 more
core   +5 more sources

Mortality Associated With Influenza and Respiratory Syncytial Virus in the US, 1999-2018

JAMA Network Open, 2022
Key Points Question What was the excess mortality from respiratory syncytial virus (RSV) and influenza in the US from 1999 to 2018? Findings This cross-sectional study estimates a mean of 6549 underlying respiratory deaths associated with RSV each year ...
C. Hansen, S. Chaves, C. Demont, C. Viboud   +3 more
semanticscholar   +1 more source

Multicenter Evaluation of the QIAstat-Dx Respiratory Panel for the Detection of Viruses and Bacteria in Nasopharyngeal Swab Specimens [PDF]

, 2020
The QIAstat-Dx Respiratory Panel (QIAstat-Dx RP) is a multiplex in vitro diagnostic test for the qualitative detection of 20 pathogens directly from nasopharyngeal swab (NPS) specimens. The assay is performed using a simple sample-to-answer platform with
Granato, Paul, Hannet, Irene, Hansen, Glen, Leber, Amy L., Lisby, Jan Gorm, Pareja, Josep, Relich, Ryan F., Schneider, Uffe Vest, Young, Stephen   +8 more
core   +1 more source

Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

Nature Communications, 2019
Cytosolic mitochondrial DNA (mtDNA) activates cGAS-mediated antiviral immune responses, but the mechanism by which RNA viruses stimulate mtDNA release remains unknown.
Miyu Moriyama, T. Koshiba, T. Ichinohe
semanticscholar   +1 more source

Influenza pathogenesis: mechanisms of modulation by agent proteins

Журнал инфектологии, 2015
Modern concepts of the influence of the proteins from viruses-etiological agents of flu – Influenzavirus A, B and C (Orthomyxoviridae) – on the development of different elements of the main disease pathogenesis are analyzed in the review.
M. Yu. Shchelkanov, A. F. Popov, A. I. Simakova, I. V. Zenin, E. S. Proshina, I. M. Kirillov, K. A. Dmitrenko, D. V. Shevchuk   +7 more
doaj   +1 more source

Obesity Increases the Duration of Influenza A Virus Shedding in Adults

Journal of Infectious Diseases, 2018
Epidemiologic studies indicate that obesity increases the risk of severe complications and death from influenza virus infections, especially in elderly individuals.
H. Maier, R. López, N. Sanchez, S. Ng, L. Gresh, S. Ojeda, Raquel Burger-Calderon, G. Kuan, E. Harris, Á. Balmaseda, A. Gordon   +10 more
semanticscholar   +1 more source