Results 31 to 40 of about 18,784 (176)

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules.

PLoS ONE, 2011
For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (
Anna Hultberg, Nigel J Temperton, Valérie Rosseels, Mireille Koenders, Maria Gonzalez-Pajuelo, Bert Schepens, Lorena Itatí Ibañez, Peter Vanlandschoot, Joris Schillemans, Michael Saunders, Robin A Weiss, Xavier Saelens, José A Melero, C Theo Verrips, Steven Van Gucht, Hans J de Haard   +15 more
doaj   +1 more source

Timing of Influenza A(H5N1) in Poultry and Humans and Seasonal Influenza Activity Worldwide, 2004–2013

Emerging Infectious Diseases, 2015
Co-circulation of influenza A(H5N1) and seasonal influenza viruses among humans and animals could lead to co-infections, reassortment, and emergence of novel viruses with pandemic potential. We assessed the timing of subtype H5N1 outbreaks among poultry,
Lizette O. Durand, Patrick Glew, Diane Gross, Matthew R. Kasper, Susan C. Trock, Inkyu K. Kim, Joseph S. Bresee, Ruben O. Donis, Timothy M. Uyeki, Marc-Alain Widdowson, Eduardo Azziz-Baumgartner   +10 more
doaj   +1 more source

Phage‐Mediated Presentation of a Conserved HA2 Epitope From Influenza A Virus Elicits Significant IgY Antibody Responses in Broiler Chickens

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
The conserved region of HA2 peptide of Influenza A virus was expressed on the surface of Protein VIII from M13 phage. Immunization of broiler chickens by this hybrid phage showed high levels of antibody responses, highlighting its potential as a promising tool for universal vaccine development against Influenza A virus.
Zinat Lotfi, Mehdi Golchin, Mohammad Ali Shamshirgaran   +2 more
wiley   +1 more source

Pathogenicity of Highly Pathogenic Avian Influenza Virus (H5N1) in Adult Mute Swans

Emerging Infectious Diseases, 2008
Adult, healthy mute swans were experimentally infected with highly pathogenic avian influenza virus A/Cygnus cygnus/Germany/R65/2006 subtype H5N1. Immunologically naive birds died, whereas animals with preexisting, naturally acquired avian influenza ...
Donata Kalthoff, Angele Breithaupt, Jens P. Teifke, Anja Globig, Timm Harder, Thomas C. Mettenleiter, Martin Beer   +6 more
doaj   +1 more source

Molecular and Phylogenetic Analysis of Hemaglutinin Gene of Avian Influenza a Viruses Subtype H5N1 Isolate from Quail [PDF]

, 2021
Teuku Zahrial Helmi, Wayan Tunas Artama, Aris Haryanto, Rumi Sahara Zamzami   +3 more
openalex   +1 more source

Advances in Microbial Diagnostics: Machine Learning and Nanotechnology for Zoonotic Disease Control

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 1, January/February 2026.
This review highlights how integrating machine learning with nanotechnology enables enhanced diagnostics, personalized treatments, and the prediction of outbreaks for zoonotic diseases, offering a unified framework to advance global health. ABSTRACT Zoonotic diseases pose significant global health threats, with microbial pathogens, including bacteria ...
Narges Lotfalizadeh, Cinzia Santucciu, Valentina Chisu, Helia Sepahvand, Abbas Rahdar, Razieh Behzadmehr, Octavio Luiz Franco, Guettari Moez, Luiz Fernando Romanholo Ferreira   +8 more
wiley   +1 more source

A replication-deficient H9N2 influenza virus carrying H5 hemagglutinin conferred protection against H9N2 and H5N1 influenza viruses in mice

Frontiers in Microbiology, 2022
H5N1 and H9N2 influenza viruses have been reported to cause human infections and are believed to have pandemic potential. The vaccine is an effective tool to prevent influenza virus infection.
Weigang Ren, Shuli Pei, Wenming Jiang, Meixia Zhao, Le Jiang, Honggang Liu, Yongxiang Yi, Yongxiang Yi, Mizhou Hui, Junwei Li, Junwei Li   +10 more
doaj   +1 more source

Exploring the Antiviral Potential of Tungsten Oxide Nanoparticles Against Herpes Simplex Virus Type 1: A Promising Alternative to Acyclovir

IET Nanobiotechnology, Volume 2026, Issue 1, 2026.
Herpes simplex virus type 1 (HSV‐1) is responsible for the majority of cold sores, herpetic keratitis‐induced blindness, profound skin lesions, and encephalitis that can be fatal. Currently, acyclovir and its derivatives are the first‐line therapy for the treatment of HSV‐1 infection.
Abdulhussain Kadhim Jwaziri, Pegah Khales, Seyed Jalal Kiani, Homayoun Yaghouti, Roghayeh Babaei, Zahra Salavatiha, Ahmad Tavakoli, Akon Higuchi   +7 more
wiley   +1 more source