Results 41 to 50 of about 243,068 (237)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Flu seasons during the period 2018-2023 in Sarajevo Canton, Bosnia and Herzegovina: possible impact of the SARS-CoV-2 pandemic on the influenza A and B virus circulation

Medicinski Glasnik
Aim During the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many countries reported a significant decrease in the prevalence of influenza virus cases.
Almedina Moro, Amela Dedeić Ljubović, Edina Zahirović, Selma Mutevelić, Suzana Arapčić, Goran Čerkez, Irma Salimović-Bešić   +6 more
doaj   +1 more source

No serological evidence that harbour porpoises are additional hosts of influenza B viruses. [PDF]

PLoS ONE, 2014
Influenza A and B viruses circulate among humans causing epidemics almost annually. While various hosts for influenza A viruses exist, influenza B viruses have been detected only in humans and seals.
Rogier Bodewes, Marco W G van de Bildt, Cornelis E van Elk, Paulien E Bunskoek, David A M C van de Vijver, Saskia L Smits, Albert D M E Osterhaus, Thijs Kuiken   +7 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Influenza B virus evolution: diversity of biological properties through the prism of genetic variability

Инфекция и иммунитет
Although the history of the influenza virus existence goes back thousands of years, the first human influenza A virus was discovered only in 1933, when proper models and substrates for virus isolation became available; then the influenza B virus was ...
Irina V. Kiseleva, N. V. Larionova, A. I. Zheltukhina   +2 more
doaj   +1 more source

POPULATION IMMUNITY TO INFLUENZA VIRUS A(H1N1)pdm09, A(H3N2) AND B IN THE ADULT POPULATION OF THE RUSSIAN FEDERATION LONG-TERM RESEARCH RESULTS

Инфекция и иммунитет, 2017
Analysis of changes in the population immunity level in adults for more than 20 Russian cities, collaborating with the Federal Center for Influenza, to circulating influenza viruses A(H1N1)pdm09, A(H3N2) and B in the period from 2009 to 2015 performed ...
O. S. Konshina, A. A. Sominina, E. A. Smorodintseva, K. A. Stolyarov, I. Yu. Nikonorov   +4 more
doaj   +1 more source

Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. [PDF]

PLoS ONE, 2009
There is an urgent need for new drugs against influenza type A and B viruses due to incomplete protection by vaccines and the emergence of resistance to current antivirals.
Kerstin Wunderlich, Daniel Mayer, Charlene Ranadheera, Anne-Sophie Holler, Benjamin Mänz, Arnold Martin, Geoffrey Chase, Werner Tegge, Ronald Frank, Ulrich Kessler, Martin Schwemmle   +10 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century.

PLoS ONE, 2019
We describe the epidemiological characteristics, pattern of circulation, and geographical distribution of influenza B viruses and its lineages using data from the Global Influenza B Study.
Saverio Caini, Gabriela Kusznierz, Verònica Vera Garate, Sonam Wangchuk, Binay Thapa, Francisco José de Paula Júnior, Walquiria Aparecida Ferreira de Almeida, Richard Njouom, Rodrigo A Fasce, Patricia Bustos, Luzhao Feng, Zhibin Peng, Jenny Lara Araya, Alfredo Bruno, Doménica de Mora, Mónica Jeannette Barahona de Gámez, Richard Pebody, Maria Zambon, Rocio Higueros, Rudevelinda Rivera, Herman Kosasih, Maria Rita Castrucci, Antonino Bella, Hervé A Kadjo, Coulibaly Daouda, Ainash Makusheva, Olga Bessonova, Sandra S Chaves, Gideon O Emukule, Jean-Michel Heraud, Norosoa H Razanajatovo, Amal Barakat, Fatima El Falaki, Adam Meijer, Gé A Donker, Q Sue Huang, Tim Wood, Angel Balmaseda, Rakhee Palekar, Brechla Moreno Arévalo, Ana Paula Rodrigues, Raquel Guiomar, Vernon Jian Ming Lee, Li Wei Ang, Cheryl Cohen, Florette Treurnicht, Alla Mironenko, Olha Holubka, Joseph Bresee, Lynnette Brammer, Mai T Q Le, Phuong V M Hoang, Clotilde El Guerche-Séblain, John Paget, Global Influenza B Study team   +54 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source