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Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su+6 more
wiley +1 more source
Anti-influenza antibody level after vaccination in north of Iran [PDF]
Objective:Influenza is a highly transmitted disease and about 10% of the world's population is affected by this disease annually. The aim of this research was to study the variation of serum antibody levels among subjects who had already been vaccinated ...
Abbasi, A.+3 more
core
Inactivated Influenza Vaccine Efficacy: Diminished Antigenicity of Split-Product Vaccines in Mice [PDF]
David W. Barry+2 more
openalex +1 more source
Abstract Clinical endpoint classification (CEC)—that is, evaluation of clinical events using pre‐defined criteria—is commonly conducted in clinical trial operations to ensure systematic and consistent assessment of endpoints needed to assess the intervention's safety and efficacy.
Veraprapas Kittipibul+13 more
wiley +1 more source
Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines [PDF]
A. N. Slepushkin+4 more
openalex +1 more source
Respiratory infections heighten risks for heart failure (HF) patients, yet 2020 data from France show low vaccination rates: 12.6% for pneumococcus and 63.1% for influenza. Using logistic regression on 763,945 HF patients, older age, female sex, and social deprivation were associated with lower pneumococcus vaccination, despite frequent healthcare ...
F. Roubille+6 more
wiley +1 more source
Antibody Responses in Serum and Nasal Secretions According to Age of Recipient and Method of Administration of A2/Hong Kong/68 Inactivated Influenza Virus Vaccine [PDF]
Robert V. Fulk+4 more
openalex +1 more source
ABSTRACT The ICH Q14 guideline introduces a structured framework for analytical method development based on Analytical Quality by Design (AQbD) principles, aiming to ensure robust, reliable, and fit‐for‐purpose methods throughout the product lifecycle.
Ewoud van Tricht+1 more
wiley +1 more source
Chromatographic isolation of the hemagglutinin polypeptides from influenza virus vaccine and determination of their amino-terminal sequences. [PDF]
Doris J. Bucher+3 more
openalex +1 more source