Analyzing the Decision to Get Flu Shot: An Empirical Study [PDF]
Influenza vaccination has been shown to be cost effective in reducing morbidity and mortality and in decreasing work absenteeism and use of health-care resources.
Gregory Yom Din +3 more
core
Pandemic Influenza Vaccines [PDF]
, 2009 Since their compositions remain uncertain, universal pandemic vaccines are yet to be created. They would aim to protect globally against pandemic influenza viruses that have not yet evolved. Thus they differ from seasonal vaccines to influenza virus, which are updated annually in spring to incorporate the latest circulating viruses, and are then ...
DiMenna, Lauren J. +1 more
openaire +2 more sources
Advanced Science, EarlyView.This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley +1 more source
Angewandte Chemie, EarlyView.The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito +9 more
wiley +2 more sources
Pandemic Flu Preparedness: Lessons From the Frontlines [PDF]
, 2009 Outlines early lessons from the 2009 H1N1 influenza outbreak and recommendations for strengthening the U.S. core public health capacity, including vaccine stockpile and development, planning and coordination, infrastructure, and surge capacity and ...
core
A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles
Advanced Science, EarlyView.A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee +6 more
wiley +1 more source
Toll-Like Receptor 7 Agonist Imiquimod in Combination with Influenza Vaccine Expedites and Augments Humoral Immune Responses against Influenza A(H1N1)pdm09 Virus Infection in BALB/c Mice [PDF]
, 2014 Jinxia Zhang +8 more
openalex +1 more source
DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition
Advanced Science, EarlyView.A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao +8 more
wiley +1 more source
Models for predicting the evolution of influenza to inform vaccine strain selection
Human Vaccines & Immunotherapeutics, 2018 Influenza vaccine composition is reviewed before every flu season because influenza viruses constantly evolve through antigenic changes. To inform vaccine updates, laboratories that contribute to the World Health Organization Global Influenza ...
Joseph K. Agor, Osman Y. Özaltın
doaj +1 more source
Effects of Different Adjuvants in the Context of Intramuscular and Intranasal Routes on Humoral and Cellular Immune Responses Induced by Detergent-Split A/H3N2 Influenza Vaccines in Mice [PDF]
, 2011 Mariana Baz +9 more
openalex +1 more source