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The potential cost-effectiveness of quadrivalent versus trivalent influenza vaccine in elderly people and clinical risk groups in the UK: a lifetime multi-cohort model. [PDF]
To estimate the potential cost-effectiveness of quadrivalent influenza vaccine compared with trivalent influenza vaccine in the UK.A lifetime, multi-cohort, static Markov model was constructed, with nine age groups each divided into healthy and at-risk ...
Laure-Anne Van Bellinghen+2 more
doaj +1 more source
Adjuvanted influenza vaccines [PDF]
The search for adjuvants has been stimulated by the need to ensure greater protection against influenza among subjects who show a reduced immune response to conventional influenza vaccines. Aluminum salts have long been used but are not considered satisfactory.
N. Principi+1 more
openaire +7 more sources
Recombinant Influenza Vaccines [PDF]
This review covers the problems encountered in the construction and production of new recombinant influenza vaccines. New approaches to the development of influenza vaccines are investigated; they include reverse genetics methods, production of virus-like particles, and DNA- and viral vector-based vaccines.
Sedova, E.+9 more
openaire +4 more sources
The Usage of Influenza Vaccine to Prevent Seasonal Influenza during Pandemic COVID-19
Influenza is an acute respiratory disease caused by influenza virus. Influenza can affect million people in every year and causing morbidity. Some of cases can be severe and need hospitalized, especially in elderly people.
Yelvi Levani, Ayu Lidya Paramita
doaj +1 more source
Broadly Protective Strategies Against Influenza Viruses: Universal Vaccines and Therapeutics
Influenza virus is a respiratory pathogen that can cause disease in humans, with symptoms ranging from mild to life-threatening. The vast majority of influenza virus infections in humans are observed during seasonal epidemics and occasional pandemics ...
Olivia A. Vogel, Balaji Manicassamy
doaj +1 more source
Conserved epitopes shared between virus subtypes are often subdominant, making it difficult to induce broadly reactive antibodies by immunization. Here, we generate a plasmid DNA mix vaccine that encodes protein heterodimers with sixteen different ...
Daniëla Maria Hinke+9 more
doaj +1 more source
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
Adjuvanted influenza vaccines [PDF]
In spite of current influenza vaccines being immunogenic, evolution of the influenza virus can reduce efficacy and so influenza remains a major threat to public health. One approach to improve influenza vaccines is to include adjuvants; substances that boost the immune response.
John S. Tregoning+2 more
openaire +6 more sources
Interim Estimates of 2018–19 Seasonal Influenza Vaccine Effectiveness — United States, February 2019
In the United States, annual vaccination against seasonal influenza is recommended for all persons aged ≥6 months (https://www.cdc.gov/flu/protect/whoshouldvax.htm). Effectiveness of seasonal influenza vaccine varies by season.
J. Doyle+21 more
semanticscholar +1 more source
Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu+6 more
wiley +1 more source