Results 41 to 50 of about 261,869 (302)

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Risk of Guillain-Barré syndrome after 2010–2011 influenza vaccination [PDF]

, 2013
Influenza vaccination has been implicated in Guillain Barré Syndrome (GBS) although the evidence for this link is controversial. A case–control study was conducted between October 2010 and May 2011 in seven Italian Regions to explore the relation between
Beghi, E, Benedetti, M D, Chiò, A, D'Alessandro, R, Filippini, G, Galeotti, F, Granieri, E, Itang, study group., Logroscino, G, Massari, M, Pugliatti, M, Raschetti, R, Santuccio, C   +12 more
core   +1 more source

Influenza vaccination in the elderly [PDF]

Human Vaccines & Immunotherapeutics, 2017
Seasonal influenza is a prevalent and serious annual illness resulting in widespread morbidity and economic disruption throughout the population; the elderly and immunocompromised are particularly vulnerable to serious sequelae and mortality. The changing demographics worldwide to an aging society have important implications for public health policy ...
Jan Smetana, Roman Chlibek, Jana Shaw, Miroslav Splino, Roman Prymula   +4 more
openaire   +4 more sources

Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions

Advanced Healthcare Materials, EarlyView.
A multi‐scale, hierarchical ‘Safety‐by‐Design’ pipeline combining machine learning, ex vivo human blood assays, and in vivo models enables the systematic immunotoxicity and biocompatibility profiling of nanoscale metal‐organic frameworks, accelerating their safe clinical translation. Abstract The clinical translation of metal‐organic frameworks (MOFs) –
Yunhui Zhuang, Bárbara B. Mendes, Dhruv Menon, Jhenifer Oliveira, Xu Chen, Fatma Demir Duman, João Conniot, Sergio Mercado, Xiewen Liu, Shi‐Yuan Zhang, João Conde, Rachel E. Hewitt, David Fairen‐Jimenez   +12 more
wiley   +1 more source

Automated Label‐Free Assay for Viral Detection and Inhibitor Screening via Biomembrane‐Functionalized Microelectrode Arrays

Advanced Materials, EarlyView.
A bioelectronic sensor integrating 2D cell membranes with organic microelectrode arrays enables detection of SARS‐CoV‐2 fusion pathways. Natively‐expressed viral receptors promote monitoring of viral entry and screening of antibody‐based inhibitors.
Zixuan Lu, Jeremy Treiber, Konstantinos Kallitsis, Ekaterina Selivanovitch, Alexandra Wheeler, Maria Lopez‐Cavestany, Zhongmou Chao, Sarah L Barron, Ju An Park, Darius Hoven, Anna Scheeder, Aimee Withers, Becky M. Hess, Clemens F. Kaminski, Alberto Salleo, Anna‐Maria Pappa, Susan Daniel, Róisín M Owens   +17 more
wiley   +1 more source

A Novel Sequence-Based Antigenic Distance Measure for H1N1, with Application to Vaccine Effectiveness and the Selection of Vaccine Strains [PDF]

, 2011
H1N1 influenza causes substantial seasonal illness and was the subtype of the 2009 influenza pandemic. Precise measures of antigenic distance between the vaccine and circulating virus strains help researchers design influenza vaccines with high vaccine ...
Brown, Caton, Daniels, Deem, Donatelli, Ferguson, K. C. Subieta, K. Pan, KEITEL, Lee, M. W. Deem, Nobusawa, Pan, Rambaut, Smith, Wiley, Zaraket   +16 more
core   +3 more sources

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Influenza vaccine: a travelers’ vaccine?

Expert Review of Vaccines, 2008
Seasonal influenza affects 5-15% of the world's population annually and is considered to be the second most frequent vaccine-preventable infection in travelers. Despite increasing travel volume worldwide, guidelines on influenza vaccination for international travel are scarce.
Marti, F, Steffen, Robert, Mütsch, Margot   +2 more
openaire   +4 more sources

Nanomaterial‐Based Optical Biosensors for SARS‐CoV‐2 Detection: A Retrospective of the Pandemic

Advanced Sensor Research, EarlyView.
This review discusses nanomaterial‐based optical biosensors developed for or adapted to the detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). It concludes by providing a perspective on how lessons learned during the coronavirus disease of 2019 (COVID‐19) pandemic may be applied for future research on nanomaterial‐based ...
Flavie Martin, Scott G. Harroun, Michel Meunier   +2 more
wiley   +1 more source

Vaccine Myths: Setting the Record Straight [PDF]

, 2018
Despite their standing as one of the most remarkable public health achievements, vaccines have been surrounded by dangerous myths since the development of the smallpox vaccine in the 18th century.
Boom, Julie A, Cunningham, Rachel M, McGee, Lindy U.   +2 more
core   +1 more source