Results 61 to 70 of about 263,867 (303)

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Knowledge, attitudes, barriers and uptake rate of influenza virus vaccine among adults with chronic diseases in Jordan: a multicentric cross-sectional study

Frontiers in Public Health
BackgroundSeasonal Influenza is a major cause of morbidity and mortality worldwide. Despite the well-established preventive role of the influenza vaccine particularly for patients at high risk, influenza vaccine uptake remains suboptimal. In Jordan, data
Munir Abu-Helalah, Munir Abu-Helalah, Tarek Gharibeh, Mohammad Al-Hanaktah, Islam Khatatbeh, Fadi Batarseh, Amro Asfour, Omar Okkeh, Abdallah Dalal, Ahmad Alhendi, Huthaifa Ababneh   +10 more
doaj   +1 more source

Comparison of the post-marketing safety profile between influenza and COVID-19 vaccines: An analysis of the vaccine adverse event reporting system

Saudi Pharmaceutical Journal, 2022
The global coronavirus disease (COVID-19) epidemic can be partially managed by vaccines; however, the public must be informed about the safety of COVID-19 vaccines to avoid hesitancy.
Abdullah K. Al-Ahmari, Amnah AlAsmari, Anoud AlKorbi, Nehad J Ahmed, Ziyad S. Almalki, Ahmed M. Alshehri, Ahmed A. Albassam, Ghada M. Alem   +7 more
doaj   +1 more source

Influenza vaccine efficacy [PDF]

Canadian Medical Association Journal, 2015
I am writing in response to a recent news article[1][1] published in CMAJ . The lack of efficacy of this year’s vaccine preparation is often used as an argument against vaccination. Although the match between the vaccine H3N2 strain and the circulating H3N2 wild-type may not be optimum, we ...
openaire   +2 more sources

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Influenza vaccine [PDF]

Paediatrics & Child Health, 2003
V A, Pai, B V, Pai
openaire   +5 more sources

Sequencing and Phylogenetic Analysis of NS Gene of Two Isolates of H9N2 Influenza Virus and The Growth Characteristics of the Virus on A549 Cells

مجله دانشکده پزشکی اصفهان, 2014
مقدمه: ویروس‌ آنفلوانزای پرندگان تحت تیپ 2N9H در طول دو دهه‌ی گذشته در آسیا به صورت پانزوتیک در آمده است. این ویروس، علاوه بر ایجاد بیماری در طیور پرورشی، چندین مورد ابتلای انسانی در آسیا را سبب شده است.
Shahla Shahsavandi, Abbas Ahmadi-Vasmehjani, Mohammad Shayestehpour, Kaweh Sadeghi, Mohammad Majid Ebrahimi, Hadi Fazel   +5 more
doaj  

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Knowledge and Attitudes of Adult Diabetic Patients Attending Primary Health Care in Bahrain about Seasonal Influenza and Influenza Vaccination - A Cross-Sectional Study

Journal of the Bahrain Medical Society
Introduction: Influenza is a highly contagious respiratory viral illness that is vaccine-preventable and occurs seasonally. While most cases present with mild respiratory symptoms, influenza can lead to severe complications in vulnerable ...
Fatema Ali Mohamed Alekri, Maryam Majeed Ahmed   +1 more
doaj   +1 more source

Age-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom [PDF]

, 2013
An analysis was undertaken to measure age-specific vaccine effectiveness (VE) of 2010/11 trivalent seasonal influenza vaccine (TIV) and monovalent 2009 pandemic influenza vaccine (PIV) administered in 2009/2010.
B. SMYTH, C. KEARNS, C. MOORE, C. ROBERTSON, Castilla, D. M. FLEMING, D. RH. THOMAS, H. DURNALL, Hardelid, J. ELLIS, J. M. WATSON, J. McMENAMIN, M. ZAMBON, N. ANDREWS, P. SEBASTIAN-PILLAI, Pebody, R. G. PEBODY, S. COTTRELL, van Buuren, W. CARMAN, Wichmann   +20 more
core   +2 more sources