Results 71 to 80 of about 263,867 (303)

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

Adjuvanted influenza vaccines [PDF]

Human Vaccines & Immunotherapeutics, 2018
In spite of current influenza vaccines being immunogenic, evolution of the influenza virus can reduce efficacy and so influenza remains a major threat to public health. One approach to improve influenza vaccines is to include adjuvants; substances that boost the immune response.
John S. Tregoning, Ryan F. Russell, Ekaterina Kinnear   +2 more
openaire   +5 more sources

Influenza and memory T cells : how to awake the force [PDF]

, 2016
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen, Hartshorn, Hufford, Jin, Jordan, Luo, Mosmann, Razvi, Topham, Topham, Topham, Von Andrian, Wijburg   +12 more
core   +3 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Influenza virus circulation and vaccine effectiveness during June 2021–May 2023 in Thailand

Vaccine: X
Thai Ministry of Public Health recommends influenza vaccination for certain risk groups. We evaluated 2023 Southern Hemisphere influenza vaccine effectiveness against medically attended influenza using surveillance data from nine Thai hospitals and a ...
Kriengkrai Prasert, Prabda Praphasiri, Sutthichai Nakphook, Darunee Ditsungnoen, Patranuch Sapchookul, Kanlaya Sornwong, Suriya Naosri, Pilailuk Akkapaiboon Okada, Piyarat Suntarattiwong, Tawee Chotpitayasunondh, Martha P. Montgomery, William W. Davis, Chakrarat Pittayawonganon   +12 more
doaj   +1 more source

Universal influenza vaccines: from viruses to nanoparticles

Expert Review of Vaccines, 2018
Introduction: The current seasonal influenza vaccine confers only limited protection due to waning antibodies or the antigenic shift and drift of major influenza surface antigens. A universal influenza vaccine which induces broad cross-protection against
Ye Wang, Lei Deng, Sang-Moo Kang, Bao-Zhong Wang   +3 more
doaj   +1 more source

A Review of the 2016-2017 Flu Season: Guidelines, Costs, and Barriers

Online Journal of Rural Nursing and Health Care, 2017
In the United States (US), about 50,000 influenza-related deaths occur annually (Centers for Medicaid and Medicare Services [CMS], 2014).  The most important preventive measure for the influenza virus is for people to obtain the influenza vaccine (Varsha
Simone Chinnis, James Sterrett, Richetta Deas, Whitney Smith, Ruth Conner   +4 more
doaj   +1 more source

Uptake rates, knowledge, attitudes, and practices toward seasonal influenza vaccination among healthcare workers in Lebanon

Human Vaccines & Immunotherapeutics, 2021
Despite recommendations and their occupational risk to influenza infection vaccine hesitancy remains a challenge among healthcare workers (HCWs). No studies have been conducted in Lebanon to assess the influenza vaccine’s acceptance among HCWs.
Malak Alame, Malak Kaddoura, Samer Kharroubi, Fatima Ezzeddine, Ghadir Hassan, Marwa Diab El-Harakeh, Lubna Al Ariqi, Abdinasir Abubaker, Hassan Zaraket   +8 more
doaj   +1 more source

Adjuvanted influenza vaccines

Expert Review of Vaccines, 2013
Influenza is one of the most common causes of human morbidity and mortality that is preventable by vaccination. Immunization with available vaccines provides incomplete protection against illness caused by influenza virus, especially in high-risk groups such as the elderly and young children.
Orli, Even-Or, Sarit, Samira, Ronald, Ellis, Eli, Kedar, Yechezkel, Barenholz   +4 more
openaire   +2 more sources

Microfluidic‐Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo‐Lysosomal Trafficking Optimization

Advanced Science, EarlyView.
This study investigates the impact of various post‐processing methods (filtration, sonication, dialysis, and heating) on lipid nanoparticles produced using microfluidics. The nanoparticles are designed for efficient delivery of miRNA into cells. The work highlights how processing conditions influence nanoparticle stability and quality, providing ...
Alicja Kosik‐Kozioł, Michał Pruchniewski, Daniel Rybak, Piotr Jenczyk, Karolina Zakrzewska, Magdalena Bartolewska, Sławomir Błoński, Paweł Nakielski, Filippo Pierini   +8 more
wiley   +1 more source