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Adjuvanted influenza vaccines [PDF]

open access: yesHuman Vaccines & Immunotherapeutics, 2018
In spite of current influenza vaccines being immunogenic, evolution of the influenza virus can reduce efficacy and so influenza remains a major threat to public health.
John S. Tregoning   +2 more
doaj   +9 more sources

Cell culture-derived flu vaccine: Present and future [PDF]

open access: yesHuman Vaccines & Immunotherapeutics, 2018
The benefit of influenza vaccines is difficult to estimate due to the complexity of accurately assessing the burden of influenza. To improve the efficacy of influenza vaccines, vaccine manufacturers have developed quadrivalent influenza vaccine (QIV ...
Alberto Pérez Rubio, Jose María Eiros
doaj   +2 more sources

Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity [PDF]

open access: yesVaccines, 2021
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies against highly variable globular head of ...
Zhuofan Li   +3 more
doaj   +4 more sources

Universal or Specific? A Modeling-Based Comparison of Broad-Spectrum Influenza Vaccines against Conventional, Strain-Matched Vaccines. [PDF]

open access: yesPLoS Computational Biology, 2016
Despite the availability of vaccines, influenza remains a major public health challenge. A key reason is the virus capacity for immune escape: ongoing evolution allows the continual circulation of seasonal influenza, while novel influenza viruses invade ...
Rahul Subramanian   +3 more
doaj   +2 more sources

Advances in Nucleic Acid Universal Influenza Vaccines [PDF]

open access: yesVaccines
Currently, vaccination with influenza vaccines is still an effective strategy to prevent infection by seasonal influenza virus in spite of some drawbacks with them.
Liang Xu   +3 more
doaj   +2 more sources

Prospects and Challenges in the Development of Universal Influenza Vaccines [PDF]

open access: yesVaccines, 2020
Current influenza vaccines offer suboptimal protection and depend on annual reformulation and yearly administration. Vaccine technology has rapidly advanced during the last decade, facilitating development of next-generation influenza vaccines that can ...
Anders Madsen, Rebecca Jane Cox
doaj   +3 more sources

Multi-COBRA hemagglutinin formulated with cGAMP microparticles elicits protective immune responses against influenza viruses [PDF]

open access: yesmSphere
In humans, seasonal influenza viruses cause epidemics. Avian influenza viruses are of particular concern because they can infect multiple species and lead to unpredictable and severe disease.
Xiaojian Zhang   +5 more
doaj   +3 more sources

The need for novel influenza vaccines in low- and middle-income countries: A narrative review [PDF]

open access: yesBrazilian Journal of Infectious Diseases
Influenza viruses cause 3–5 million severe cases and 300,000–600,000 deaths worldwide. Most of the disease burden is in Low- and Middle-Income Countries (LMICs) owing to factors such as high population density, infrastructure challenges, poor quality ...
Julia R. Spinardi   +4 more
doaj   +2 more sources

Vaccines for Influenza [PDF]

open access: yesVaccines, 2021
Two reviews by Harding and Heaton [...]
Apostolos P. Georgopoulos   +4 more
openaire   +3 more sources

Influenza Vaccines

open access: yesNature Reviews Drug Discovery, 2006
Mark J, Belsey   +3 more
europepmc   +3 more sources

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