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Advances in Development and Application of Influenza Vaccines

Frontiers in Immunology, 2021
Influenza A virus is one of the most important zoonotic pathogens that can cause severe symptoms and has the potential to cause high number of deaths and great economic loss.
Jidang Chen, Hinh Ly, Ly Hinh
exaly   +4 more sources

Influenza Viruses and Vaccines: The Role of Vaccine Effectiveness Studies for Evaluation of the Benefits of Influenza Vaccines

Vaccines, 2022
Influenza is a vaccine preventable disease and vaccination remains the most effective method of controlling the morbidity and mortality of seasonal influenza, especially with respect to risk groups.
Claudia Maria Trombetta, Otfried Kistner, Emanuele Montomoli, Simonetta Viviani, Serena Marchi   +4 more
doaj   +2 more sources

Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity

Vaccines, 2021
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies against highly variable globular head of ...
Zhuofan Li, Yiwen Zhao, Yibo Li, Xinyuan Chen   +3 more
doaj   +2 more sources

Next-generation influenza vaccines: opportunities and challenges

Nature Reviews Drug Discovery, 2020
Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains. Developing improved vaccines that elicit broader immunity remains a public health priority.
Chih-Jen Wei, Michelle C Crank, Barney S Graham   +2 more
exaly   +2 more sources

Quadrivalent influenza nanoparticle vaccines induce broad protection

Nature, 2021
Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and immunization1.
Seyhan Boyoglu-Barnum, Geoffrey B Hutchinson, Young Jun Park   +2 more
exaly   +2 more sources

Impact of the coronavirus disease 2019 epidemic and a free influenza vaccine strategy on the willingness of residents to receive influenza vaccines in Shanghai, China

Human Vaccines & Immunotherapeutics, 2021
The influenza vaccine is not included in China’s national immunization program. Here, we assessed influenza vaccine coverage among Shanghai residents and estimated the impacts of the coronavirus disease 2019 (COVID-19) epidemic and a hypothetical free ...
Yehong Zhou, Jing Tang, Junjie Zhang, Qiangsong Wu   +3 more
doaj   +2 more sources

Current and future influenza vaccines

Nature Medicine, 2019
Although antiviral drugs and vaccines have reduced the economic and healthcare burdens of influenza, influenza epidemics continue to take a toll. Over the past decade, research on influenza viruses has revealed a potential path to improvement.
Seiya Yamayoshi, Yoshihiro Kawaoka, Yamayoshi Seiya   +2 more
exaly   +2 more sources

Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines

Vaccines, 2020
Ever since the discovery of vaccines, many deadly diseases have been contained worldwide, ultimately culminating in the eradication of smallpox and polio, which represented significant medical achievements in human health.
Ekramy E. Sayedahmed, Ahmed Elkashif, Marwa Alhashimi, Suryaprakash Sambhara, Suresh K. Mittal   +4 more
doaj   +2 more sources

Adjuvanted influenza vaccines

Human Vaccines & Immunotherapeutics, 2018
In spite of current influenza vaccines being immunogenic, evolution of the influenza virus can reduce efficacy and so influenza remains a major threat to public health.
John S. Tregoning, Ryan F. Russell, Ekaterina Kinnear   +2 more
doaj   +2 more sources

Prospects and Challenges in the Development of Universal Influenza Vaccines

Vaccines, 2020
Current influenza vaccines offer suboptimal protection and depend on annual reformulation and yearly administration. Vaccine technology has rapidly advanced during the last decade, facilitating development of next-generation influenza vaccines that can ...
Anders Madsen, Rebecca Jane Cox
doaj   +2 more sources