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Development and Regulation of Novel Influenza Virus Vaccines: A United States Young Scientist Perspective [PDF]

Vaccines, 2018
Vaccination against influenza is the most effective approach for reducing influenza morbidity and mortality. However, influenza vaccines are unique among all licensed vaccines as they are updated and administered annually to antigenically match the ...
Surender Khurana
doaj   +2 more sources

Adjuvanted influenza vaccines [PDF]

Human Vaccines & Immunotherapeutics, 2018
In spite of current influenza vaccines being immunogenic, evolution of the influenza virus can reduce efficacy and so influenza remains a major threat to public health.
John S. Tregoning, Ryan F. Russell, Ekaterina Kinnear   +2 more
doaj   +5 more sources

Influenza Vaccines

Nature Reviews Drug Discovery, 2006
Mark J, Belsey, Brigitte, de Lima, Alex K, Pavlou, John W, Savopoulos   +3 more
europepmc   +3 more sources

Intranasal powder live attenuated influenza vaccine is thermostable, immunogenic, and protective against homologous challenge in ferrets

npj Vaccines, 2021
Influenza viruses cause annual seasonal epidemics and sporadic pandemics; vaccination is the most effective countermeasure. Intranasal live attenuated influenza vaccines (LAIVs) are needle-free, mimic the natural route of infection, and elicit robust ...
Jasmina M. Luczo, Tatiana Bousse, Scott K. Johnson, Cheryl A. Jones, Nicholas Pearce, Carlie A. Neiswanger, Min-Xuan Wang, Erin A. Miller, Nikolai Petrovsky, David E. Wentworth, Victor Bronshtein, Mark Papania, Stephen M. Tompkins   +12 more
doaj   +1 more source

Influenza vaccines [PDF]

Vaccine, 2009
Influenza A viruses pose a substantial threat to the human population whether by purposeful manipulation and release or by the natural process of interspecies transmissions from animal reservoirs. The challenge with preparing for these events with vaccination strategies is that the best forms of protective immunity target the most variable of the viral
A H, Ellebedy, R J, Webby
openaire   +2 more sources

A DNA Vaccine That Encodes an Antigen-Presenting Cell-Specific Heterodimeric Protein Protects against Cancer and Influenza

Molecular Therapy: Methods & Clinical Development, 2020
Immunogenicity of DNA vaccines can be increased by constructing the DNA in such a way that it encodes secreted homodimeric fusion proteins that target antigen-presenting cells (APCs). In this study, we have developed novel APC-targeting vaccine molecules
Ranveig Braathen, Heidi Cecilie Larsen Spång, Daniëla Maria Hinke, Jana Blazevski, Sonja Bobic, Even Fossum, Bjarne Bogen   +6 more
doaj   +1 more source

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection

Frontiers in Immunology, 2022
Targeting antigen to conventional dendritic cells (cDCs) can improve antigen-specific immune responses and additionally be used to influence the polarization of the immune responses. However, the mechanisms by which this is achieved are less clear.
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Sonja Bobic, Sonja Bobic, Anna Lysén, Anna Lysén, Peter Csaba Huszthy, Peter Csaba Huszthy, Arnar Gudjonsson, Arnar Gudjonsson, Ranveig Braathen, Ranveig Braathen, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +16 more
doaj   +1 more source

Advances in Development and Application of Influenza Vaccines

Frontiers in Immunology, 2021
Influenza A virus is one of the most important zoonotic pathogens that can cause severe symptoms and has the potential to cause high number of deaths and great economic loss.
Jidang Chen, Jiehuang Wang, Jipei Zhang, Hinh Ly   +3 more
doaj   +1 more source

Influenza Vaccination

Annals of Saudi Medicine, 1999
Nurses have an important part to play in dispelling myths about influenza vaccination and in actively encouraging older people to attend for vaccination. Irene Schofield discusses the issues.
A, Uma, P, Thirumalaikolundusubramanian
openaire   +5 more sources

Solid bioneedle-delivered influenza vaccines are highly thermostable and induce both humoral and cellular immune responses. [PDF]

PLoS ONE, 2014
The potential of bioneedles to deliver influenza vaccines was investigated. Four influenza vaccine formulations were screened to determine the optimal formulation for use with bioneedles.
Peter C Soema, Geert-Jan Willems, Klaas van Twillert, Gijsbert van de Wijdeven, Claire J Boog, Gideon F A Kersten, Jean-Pierre Amorij   +6 more
doaj   +1 more source