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Influenza and Memory T Cells: How to Awake the Force [PDF]

Vaccines, 2016
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals ...
Jan Spitaels, Kenny Roose, Xavier Saelens   +2 more
doaj   +4 more sources

Adjuvanted influenza vaccines [PDF]

Human Vaccines & Immunotherapeutics, 2018
In spite of current influenza vaccines being immunogenic, evolution of the influenza virus can reduce efficacy and so influenza remains a major threat to public health.
John S. Tregoning, Ryan F. Russell, Ekaterina Kinnear   +2 more
doaj   +6 more sources

Vaccines for Influenza [PDF]

Vaccines, 2021
Two reviews by Harding and Heaton [...]
Apostolos P. Georgopoulos, Apostolos P. Georgopoulos, Spyros Charonis, Spyros Charonis, Effie Photini C. Tsilibary   +4 more
openaire   +3 more sources

Influenza Virus and Vaccination [PDF]

Pathogens, 2020
Influenza virus infections represent a serious public health problem causing contagious respiratory disease and substantial morbidity and mortality in humans, resulting in a considerable economic burden worldwide. Notably, the number of deaths due to influenza exceeds that of any other known pathogen.
Aitor Nogales, Marta L. DeDiego
openaire   +6 more sources

Intranasal powder live attenuated influenza vaccine is thermostable, immunogenic, and protective against homologous challenge in ferrets

npj Vaccines, 2021
Influenza viruses cause annual seasonal epidemics and sporadic pandemics; vaccination is the most effective countermeasure. Intranasal live attenuated influenza vaccines (LAIVs) are needle-free, mimic the natural route of infection, and elicit robust ...
Jasmina M. Luczo, Tatiana Bousse, Scott K. Johnson, Cheryl A. Jones, Nicholas Pearce, Carlie A. Neiswanger, Min-Xuan Wang, Erin A. Miller, Nikolai Petrovsky, David E. Wentworth, Victor Bronshtein, Mark Papania, Stephen M. Tompkins   +12 more
doaj   +1 more source

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection

Frontiers in Immunology, 2022
Targeting antigen to conventional dendritic cells (cDCs) can improve antigen-specific immune responses and additionally be used to influence the polarization of the immune responses. However, the mechanisms by which this is achieved are less clear.
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Sonja Bobic, Sonja Bobic, Anna Lysén, Anna Lysén, Peter Csaba Huszthy, Peter Csaba Huszthy, Arnar Gudjonsson, Arnar Gudjonsson, Ranveig Braathen, Ranveig Braathen, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +16 more
doaj   +1 more source

Influenza and the influenza vaccine [PDF]

Canadian Medical Association Journal, 2007
Influenza, or the “flu,” is an infection caused by the influenza virus. The virus infects the nose and throat, and it can sometimes spread to the lungs. Influenza commonly causes acute fever, cough, chills, tiredness, body aches and, in young children, ear aches.
Joanne M. Langley, Erica Weir, Noni E. MacDonald   +2 more
openaire   +3 more sources

A DNA Vaccine That Encodes an Antigen-Presenting Cell-Specific Heterodimeric Protein Protects against Cancer and Influenza

Molecular Therapy: Methods & Clinical Development, 2020
Immunogenicity of DNA vaccines can be increased by constructing the DNA in such a way that it encodes secreted homodimeric fusion proteins that target antigen-presenting cells (APCs). In this study, we have developed novel APC-targeting vaccine molecules
Ranveig Braathen, Heidi Cecilie Larsen Spång, Daniëla Maria Hinke, Jana Blazevski, Sonja Bobic, Even Fossum, Bjarne Bogen   +6 more
doaj   +1 more source

Advances in Development and Application of Influenza Vaccines

Frontiers in Immunology, 2021
Influenza A virus is one of the most important zoonotic pathogens that can cause severe symptoms and has the potential to cause high number of deaths and great economic loss.
Jidang Chen, Jiehuang Wang, Jipei Zhang, Hinh Ly   +3 more
doaj   +1 more source

DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8+ T Cell Responses, Enabling Faster Resolution of Influenza Disease [PDF]

, 2016
Current influenza vaccines are effective but imperfect, failing to cover against emerging strains of virus and requiring seasonal administration to protect against new strains. A key step to improving influenza vaccines is to improve our understanding of
Bogen, B, Brunsvik Frediksen, A, Grodeland, G, Kinnear, E, Lambert, L, Lindberg, MM, Mcdonald, JU, Stubsrud, E, Tregoning, JS   +8 more
core   +7 more sources