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Animal Models Utilized for the Development of Influenza Virus Vaccines

Vaccines, 2021
Animal models have been an important tool for the development of influenza virus vaccines since the 1940s. Over the past 80 years, influenza virus vaccines have evolved into more complex formulations, including trivalent and quadrivalent inactivated ...
Ericka Kirkpatrick Roubidoux, Stacey Schultz-Cherry   +1 more
doaj   +2 more sources

Navigating the Transition to RNA-Based Influenza Vaccines: A State-of-the-Art Review. [PDF]

Vaccines (Basel)
Seasonal influenza and the ongoing emergence of zoonotic influenza viruses, including highly pathogenic avian influenza A (H5N1), remain substantial global public health threats, underscoring the need for rapidly adaptable vaccine platforms.
Panagiotopoulos AP, Tsakri D, Laskaris A, Saldari C, Ranellou K, Mariolis I, Tsakris A, Anastassopoulou C.   +7 more
europepmc   +2 more sources

Intranasal powder live attenuated influenza vaccine is thermostable, immunogenic, and protective against homologous challenge in ferrets

npj Vaccines, 2021
Influenza viruses cause annual seasonal epidemics and sporadic pandemics; vaccination is the most effective countermeasure. Intranasal live attenuated influenza vaccines (LAIVs) are needle-free, mimic the natural route of infection, and elicit robust ...
Jasmina M. Luczo, Tatiana Bousse, Scott K. Johnson, Cheryl A. Jones, Nicholas Pearce, Carlie A. Neiswanger, Min-Xuan Wang, Erin A. Miller, Nikolai Petrovsky, David E. Wentworth, Victor Bronshtein, Mark Papania, Stephen M. Tompkins   +12 more
doaj   +1 more source

A DNA Vaccine That Encodes an Antigen-Presenting Cell-Specific Heterodimeric Protein Protects against Cancer and Influenza

Molecular Therapy: Methods & Clinical Development, 2020
Immunogenicity of DNA vaccines can be increased by constructing the DNA in such a way that it encodes secreted homodimeric fusion proteins that target antigen-presenting cells (APCs). In this study, we have developed novel APC-targeting vaccine molecules
Ranveig Braathen, Heidi Cecilie Larsen Spång, Daniëla Maria Hinke, Jana Blazevski, Sonja Bobic, Even Fossum, Bjarne Bogen   +6 more
doaj   +1 more source

Advances in Development and Application of Influenza Vaccines

Frontiers in Immunology, 2021
Influenza A virus is one of the most important zoonotic pathogens that can cause severe symptoms and has the potential to cause high number of deaths and great economic loss.
Jidang Chen, Jiehuang Wang, Jipei Zhang, Hinh Ly   +3 more
doaj   +1 more source

Influenza Viruses and Vaccines: The Role of Vaccine Effectiveness Studies for Evaluation of the Benefits of Influenza Vaccines

Vaccines, 2022
Influenza is a vaccine preventable disease and vaccination remains the most effective method of controlling the morbidity and mortality of seasonal influenza, especially with respect to risk groups.
Claudia Maria Trombetta, Otfried Kistner, Emanuele Montomoli, Simonetta Viviani, Serena Marchi   +4 more
doaj   +1 more source

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection

Frontiers in Immunology, 2022
Targeting antigen to conventional dendritic cells (cDCs) can improve antigen-specific immune responses and additionally be used to influence the polarization of the immune responses. However, the mechanisms by which this is achieved are less clear.
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Sonja Bobic, Sonja Bobic, Anna Lysén, Anna Lysén, Peter Csaba Huszthy, Peter Csaba Huszthy, Arnar Gudjonsson, Arnar Gudjonsson, Ranveig Braathen, Ranveig Braathen, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +16 more
doaj   +1 more source

Solid bioneedle-delivered influenza vaccines are highly thermostable and induce both humoral and cellular immune responses. [PDF]

PLoS ONE, 2014
The potential of bioneedles to deliver influenza vaccines was investigated. Four influenza vaccine formulations were screened to determine the optimal formulation for use with bioneedles.
Peter C Soema, Geert-Jan Willems, Klaas van Twillert, Gijsbert van de Wijdeven, Claire J Boog, Gideon F A Kersten, Jean-Pierre Amorij   +6 more
doaj   +1 more source

Engineered Nanoparticulate Vaccines to Combat Recurring and Pandemic Influenza Threats

Advanced NanoBiomed Research, 2022
Recurring seasonal flu epidemics and occasional pandemics are among the most severe threats to public health. Current seasonal influenza vaccines provide limited protection against drifted circulating strains and no protection against influenza pandemics.
Chunhong Dong, Bao-Zhong Wang
doaj   +1 more source

Haemagglutination inhibition and virus microneutralisation serology assays: use of harmonised protocols and biological standards in seasonal influenza serology testing and their impact on inter-laboratory variation and assay correlation: A FLUCOP collaborative study

Frontiers in Immunology, 2023
IntroductionThe haemagglutination inhibition assay (HAI) and the virus microneutralisation assay (MN) are long-established methods for quantifying antibodies against influenza viruses. Despite their widespread use, both assays require standardisation to
Joanna Waldock, Edmond J. Remarque, Lingyi Zheng, Sammy Ho, Katja Hoschler, Britta Neumann, Hanna Sediri-Schön, Claudia M. Trombetta, Emanuele Montomoli, Serena Marchi, Giulia Lapini, Fan Zhou, Sarah L. Lartey, Rebecca J. Cox, Marzia Facchini, Maria Rita Castrucci, Damien Friel, Thierry Ollinger, Catherine Caillet, Nedzad Music, Giuseppe Palladino, Othmar G. Engelhardt, the FLUCOP consortium   +22 more
doaj   +1 more source