Results 91 to 100 of about 201,288 (355)

The Evolutionary Vaccination Dilemma in Complex Networks [PDF]

Phys. Rev. E 88, 032803 (2013), 2013
In this work we analyze the evolution of voluntary vaccination in networked populations by entangling the spreading dynamics of an influenza-like disease with an evolutionary framework taking place at the end of each influenza season so that individuals take or not the vaccine upon their previous experience.
arxiv   +1 more source

Virus Sharing, Genetic Sequencing, and Global Health Security [PDF]

, 2014
The WHO’s Pandemic Influenza Preparedness (PIP) Framework was a milestone global agreement designed to promote the international sharing of biological samples to develop vaccines, while that ensuring poorer countries would have access to those vaccines ...
A. Phelan, Fidler, J. D. Kraemer, K. S. Reddy, L. O. Gostin, M. A. Stoto, Sedyaningsih   +6 more
core   +3 more sources

Sustained Vaccine Exposure Elicits More Rapid, Consistent, and Broad Humoral Immune Responses to Multivalent Influenza Vaccines

Advanced Science, EarlyView.
This work presents an injectable polymer‐nanoparticle hydrogel depot platform for delivering multivalent influenza vaccines which induces stronger and more durable immune responses. The technology provides broader protection, including against heterologous and potential pandemic strains (H5N1, H7N9, H9N2), and enhances the effectiveness of commercial ...
Olivia M. Saouaf, Ben S. Ou, Ye Eun Song, Joshua J. Carter, Jerry Yan, Carolyn K. Jons, Christopher O. Barnes, Eric A. Appel   +7 more
wiley   +1 more source

An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged mice

Human Vaccines & Immunotherapeutics
Currently, vaccination with influenza vaccines is still an effective strategy to prevent infection by seasonal influenza virus. However, seasonal influenza vaccines frequently fail to induce effective immune protection against rapidly changing seasonal ...
Liang Xu, Zhihao Yu, Yifan Xu, Qin Wang, Guiqin Wang, Benchi Li, Qian Weng, Yongxiang Yi, Junwei Li   +8 more
doaj   +1 more source

Transient humoral protection against H5N1 challenge after seasonal influenza vaccination of humans. [PDF]

PLoS ONE, 2014
Current influenza vaccines are believed to confer protection against a narrow range of virus strains. The identification of broadly influenza neutralizing antibodies (bnAbs) has triggered efforts to develop vaccines providing 'universal' protection ...
Ramon Roozendaal, Jeroen Tolboom, Anna Roos, Sarra Riahi, Jessica Theeuwsen, Miriam V Bujny, Vincent Klaren, Hans J W M Korse, Liesbeth Dekking, Arijan Grootenhuis, Gerrit Jan Weverling, Wouter Koudstaal, Jaap Goudsmit, Katarina Radošević   +13 more
doaj   +1 more source

The Benefits and Risks of Pandemic Influenza Vaccines [PDF]

, 2015
In 2009 and 2010 the world experienced the first influenza pandemic of the 21st century. As the new influenza A(H1N1)pdm09 virus spread across the world, vaccines were being produced and licensed at an unprecedented scale and speed. In Europe, adjuvanted
Wijnans, E.G. (Leonoor)
core   +1 more source

T‐Cell‐Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS‐CoV‐2 Infection

Advanced Science, EarlyView.
This study describes the development of spike‐targeting T‐cell‐dependent bispecific full‐length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID‐19. The significance of T‐cell‐based immunity during infection is highlighted. These results have significant implications for better clinical effectiveness of therapies for COVID‐19 ...
Wenyan Fu, Wei Zhang, Zhongshuai You, Guangyao Li, Chuqi Wang, Changhai Lei, Jian Zhao, Jin Hou, Shi Hu   +8 more
wiley   +1 more source

Long‐Term COVID‐19 Smell and Taste Disorders Differ Significantly from Other Post‐Infectious Cases

The Laryngoscope, Volume 133, Issue 1, Page 169-174, January 2023., 2023
Introduction COVID‐19 is causing a wide range of clinical manifestations. Severe complications and long‐lasting sequelae have been identified. Thus, olfactory disorders are reported in up to 86% of cases in mild and moderate COVID‐19 infections. We present the first study comparing simple and complex post‐COVID‐19 cases with matched non‐COVID‐19 post ...
Dovile Stankevice, Alexander Wieck Fjaeldstad, Jane Agergaard, Therese Ovesen   +3 more
wiley   +1 more source

Nonreplicating Influenza A Virus Vaccines Confer Broad Protection against Lethal Challenge

mBio, 2015
New vaccine technologies are being investigated for their ability to elicit broadly cross-protective immunity against a range of influenza viruses. We compared the efficacies of two intranasally delivered nonreplicating influenza virus vaccines (H1 and ...
Mariana Baz, Kobporn Boonnak, Myeisha Paskel, Celia Santos, Timothy Powell, Alain Townsend, Kanta Subbarao   +6 more
doaj   +1 more source

Epitope analysis for influenza vaccine design [PDF]

arXiv, 2004
Until now, design of the annual influenza vaccine has relied on phylogenetic or whole-sequence comparisons of the viral coat proteins hemagglutinin and neuraminidase, with vaccine effectiveness assumed to correlate monotonically to the vaccine-influenza sequence difference. We use a theory from statistical mechanics to quantify the non-monotonic immune
arxiv