Results 91 to 100 of about 968,734 (398)

Trends of influenza B during the 2010–2016 seasons in 2 regions of north and south Italy: The impact of the vaccine mismatch on influenza immunisation strategy [PDF]

, 2018
Influenza A and B viruses are responsible for respiratory infections, representing globally seasonal threats to human health. The 2 viral types often co-circulate and influenza B plays an important role in the spread of infection.
Alicino C., Ansaldi F., Calamusa G., Canepa P., Colomba G. M. E., Orsi A., Pojero F., Tramuto F., Trucchi C., Vitale F.   +9 more
core   +1 more source

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Advanced Functional Materials, EarlyView.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song, Marc Ferrer, Emily M. Lee   +5 more
wiley   +1 more source

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Enhanced isolation of influenza viruses in qualified cells improves the probability of well-matched vaccines

npj Vaccines, 2021
Influenza vaccines are utilised to combat seasonal and pandemic influenza. The key to influenza vaccination currently is the availability of candidate vaccine viruses (CVVs).
Heidi Peck, Karen L. Laurie, Steve Rockman, Vivian Leung, Hilda Lau, Sally Soppe, Cleve Rynehart, Chantal Baas, Heidi Trusheim, Ian G. Barr   +9 more
doaj   +1 more source

Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina [PDF]

, 2015
Background: Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries.
Azziz Baumgartner, Eduardo, Carballal, Guadalupe, Durand, Lizette O., Echavarría, Marcela Silvia, Ekstrom, Jorge, Marcone, Débora Natalia, Vidaurreta, Santiago Manuel   +6 more
core   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Characterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium [PDF]

, 2019
Funding text The authors are grateful for the vital contributions of the participating study volunteers, clinicians, nurses, and laboratory technicians at the Surrey study site.
Bodinham, C., Bottazzi, B., DelGiudice, G., Denoel, P., Greenwood, A., Jonsdottir, I., Kaufmann, S., Kester, K., Leroux-Roels, G., Lewis, D., Linley, C., Maertzdorf, J., Mantovani, A., Mollenkopf, H., Pizzoferro, K., van den Berg, R., Weiner, J.   +16 more
core   +1 more source

Vaccines for Pandemic Influenza

Emerging Infectious Diseases, 2006
Recent outbreaks of highly pathogenic avian influenza in Asia and associated human infections have led to a heightened level of awareness and preparation for a possible influenza pandemic. Vaccination is the best option by which spread of a pandemic virus could be prevented and severity of disease reduced.
Luke, CJ, Subbarao, K
openaire   +4 more sources

Free‐Form Microfluidic Microneedle Array Patches

Advanced Functional Materials, EarlyView.
Microfluidic microneedle array patches (MAPs) integrate hollow microneedles with embedded microfluidic channels, fabricated using high‐resolution 3D printing, to enable controlled transdermal delivery of liquid, mixed, or reconstituted therapeutics.
Ian A. Coates, Madison M. Driskill, Netra U. Rajesh, Gabriel Lipkowitz, Dan Ilyn, Yue Xu, Maria T. Dulay, Gunilla B. Jacobson, John R. Tumbleston, Jillian L. Perry, Shaomin Tian, Joseph M. DeSimone   +11 more
wiley   +1 more source

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, EarlyView.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source