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Influenza vaccine: a travelers’ vaccine?
Expert Review of Vaccines, 2008 Seasonal influenza affects 5-15% of the world's population annually and is considered to be the second most frequent vaccine-preventable infection in travelers. Despite increasing travel volume worldwide, guidelines on influenza vaccination for international travel are scarce.
Marti, F +2 more
openaire +4 more sources
Adjuvanted influenza vaccines [PDF]
Human Vaccines & Immunotherapeutics, 2012 The search for adjuvants has been stimulated by the need to ensure greater protection against influenza among subjects who show a reduced immune response to conventional influenza vaccines. Aluminum salts have long been used but are not considered satisfactory.
N. Principi, S. Esposito
openaire +5 more sources
Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines
mBio, 2019 Current seasonal influenza vaccines are suboptimal and low in immunogenicity and do not provide long-lasting immunity and cross protection against influenza virus strains that have antigenically drifted. More-effective influenza vaccines which can induce
Pui Wang +17 more
semanticscholar +1 more source
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Advax-SM™-Adjuvanted COBRA (H1/H3) Hemagglutinin Influenza Vaccines
Adjuvants enhance immune responses stimulated by vaccines. To date, many seasonal influenza vaccines are not formulated with an adjuvant. In the present study, the adjuvant Advax-SM™ was combined with next generation, broadly reactive influenza ...
Sanchez, P.L. +9 more
core +1 more source
Nonreplicating Influenza A Virus Vaccines Confer Broad Protection against Lethal Challenge
mBio, 2015 New vaccine technologies are being investigated for their ability to elicit broadly cross-protective immunity against a range of influenza viruses. We compared the efficacies of two intranasally delivered nonreplicating influenza virus vaccines (H1 and ...
Mariana Baz +6 more
doaj +1 more source
Pandemic Influenza Vaccines [PDF]
, 2009 Since their compositions remain uncertain, universal pandemic vaccines are yet to be created. They would aim to protect globally against pandemic influenza viruses that have not yet evolved. Thus they differ from seasonal vaccines to influenza virus, which are updated annually in spring to incorporate the latest circulating viruses, and are then ...
DiMenna, Lauren J. +1 more
openaire +2 more sources
M2e-based universal influenza vaccines: a historical overview and new approaches to development
Journal of Biomedical Sciences, 2019 The influenza A virus was isolated for the first time in 1931, and the first attempts to develop a vaccine against the virus began soon afterwards. In addition to causing seasonal epidemics, influenza viruses can cause pandemics at random intervals ...
Daria А. Mezhenskaya +2 more
semanticscholar +1 more source
Advanced Science, EarlyView.Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao +19 more
wiley +1 more source
The averted costs due to influenza vaccination with trivalent and quadrivalent vaccines
Журнал инфектологии, 2017 Now WHO experts annually formulates references on structure of both the 3rd, and 4 valent vaccines against influenza applied worldwide.The purpose of work was the assessment of averted costs due to influenza vaccination with trivalent and quadrivalent ...
S. M. Kharit +4 more
doaj +1 more source