Results 121 to 130 of about 201,288 (355)

Increasing Herd Immunity with Influenza Revaccination [PDF]

arXiv, 2013
Seasonal influenza is a significant public health concern in the United States and globally. While influenza vaccines are the single most effective intervention to reduce influenza morbidity and mortality, there is considerable debate surrounding the merits and consequences of repeated seasonal vaccination.
arxiv  

Influenza Virus Vaccine Efficacy Based On Conserved Sequence Alignment [PDF]

, 2012
The rapid outbreak of bird flu challenges the outcome of effective vaccine for the upcoming years. The recent research established different norms to eliminate flu pandemics. This can be made possible with skilled experimental analyses and by tracking the recent virulent strain and can be broadly applicable with effective testing of vaccine efficacy ...
arxiv   +1 more source

Targeting Antigen‐Presenting Cells to Enhance the Tumor‐Spleen Immunity Cycle through Liposome‐Neoantigen Vaccine

Advanced Science, EarlyView.
LNPsD18, a cationic liposome that enhances antigen‐presenting cell uptake in the spleen and tumor without targeting ligands is developed. Co‐delivering neoantigens and a TLR9 agonist significantly improve DC activation, tumor immunity, and survival in liver and colorectal cancer models, demonstrating the importance of dual‐site APC targeting for cancer
Yu Xu, Bing Wang, Yue Huang, JianPing Liao, Chenyi Wu, Chenxi Zhou, Zishi Kang, Shiyang Jiang, Bing‐Chen Wu, Da Zhang, Ruihua Xu, Xiaolong Liu, Feng Wang   +12 more
wiley   +1 more source

Predicting influenza H3N2 vaccine efficacy from evolution of the dominant epitope [PDF]

arXiv, 2018
We predict vaccine efficacy with a measure of antigenic distance between influenza A(H3N2) and candidate vaccine viruses based on amino acid substitutions in the dominant epitopes. In 2016-2017, our model predicts 19% efficacy compared to 20% observed.
arxiv  

Reduction in respiratory mortality not associated with influenza in Russia: effect of the introduction of pneumococcal vaccination (PCV13), or improvement in care? [PDF]

arXiv, 2020
Background. Pneumococcal vaccination (PCV13) for children (as well as older adults) in Russia was introduced in 2014, with no prior PCV7 use. While pneumonia hospitalization rates, both in children and adults did not decrease in the following years, respiratory mortality rates did decline with time.
arxiv  

Restoring Tumor Cell Immunogenicity Through Ion‐Assisted p53 mRNA Domestication for Enhanced In Situ Cancer Vaccination Effect

Advanced Science, EarlyView.
PRIZE, a P53‐repair nanosystem based on a virus‐mimicking nanostructure, delivers p53 mRNA into tumor cells, restoring P53 levels and enhancing immunogenicity. Its biomineralized structure stabilizes the mRNA, prolongs P53's half‐life, and precisely targets tumors.
Yan Liang, Jingge Zhang, Jinjin Wang, Yuhe Yang, Xinyu Tan, Shuguang Li, Zhenzhen Guo, Zhenzhong Zhang, Junjie Liu, Jinjin Shi, Kaixiang Zhang   +10 more
wiley   +1 more source

Safety and immunogenicity of mRNA COVID‐19 vaccine in inpatients with muscular dystrophy

Muscle &Nerve, Volume 67, Issue 2, Page 117-123, February 2023., 2023
Abstract Introduction/Aims Due to muscular weakness and cardiopulmonary dysfunction, patients with muscular dystrophy (MD) have an increased risk of serious complications from coronavirus disease‐2019 (COVID‐19). Although vaccination is recommended, COVID‐19 vaccination safety and immunogenicity in these patients are unknown.
Tomoko Saito, Toshio Saito, Hiroya Hashimoto, Katsuhisa Ogata, Michio Kobayashi, Hiroto Takada, Satoshi Kuru, Takashi Kimura, Akinori Nakamura, Tsuyoshi Matsumura   +9 more
wiley   +1 more source

Religious Festivals and Influenza [PDF]

arXiv, 2017
Objectives Influenza outbreaks have been widely studied. However, the patterns between influenza and religious festivals remained unexplored. This study examined the patterns of influenza and Hanukkah in Israel, and that of influenza and Hajj in Bahrain, Egypt, Iraq, Jordan, Oman and Qatar.
arxiv  

Individual vaccination as Nash equilibrium in a SIR model with application to the 2009-10 Influenza A(H1N1) epidemic in France [PDF]

Bull Math Biol 77, 1955-1984 (2015)
The vaccination against ongoing epidemics is seldom compulsory but remains one of the most classical means to fight epidemic propagation. However recent debates concerning the innocuity of vaccines and their risk with respect to the risk of the epidemic itself lead to severe vaccination campaign failures and new mass behaviors appeared driven by ...
arxiv   +1 more source

Pandemic Influenza Vaccines [PDF]

, 2009
Since their compositions remain uncertain, universal pandemic vaccines are yet to be created. They would aim to protect globally against pandemic influenza viruses that have not yet evolved. Thus they differ from seasonal vaccines to influenza virus, which are updated annually in spring to incorporate the latest circulating viruses, and are then ...
Lauren J. DiMenna, Hildegund C. J. Ertl
openaire   +3 more sources