Results 141 to 150 of about 201,288 (355)

Patterns of Influenza Vaccination Coverage in the United States from 2009 to 2015 [PDF]

arXiv, 2017
Background: Globally, influenza is a major cause of morbidity, hospitalization and mortality. Influenza vaccination has shown substantial protective effectiveness in the United States. We investigated state-level patterns of coverage rates of seasonal and pandemic influenza vaccination, among the overall population in the U.S.
arxiv  

Impairment of Innate Immunity and Depletion of Vaccine‐Induced Memory B and T Cells in the Absence of the Spleen

American Journal of Hematology, EarlyView.
ABSTRACT Splenectomy or congenital asplenia is associated with severe reduction of memory B cells and increased risk of fulminant sepsis by encapsulated bacteria. Current guidelines recommend vaccinations against these pathogens before or after splenectomy, but the longevity of immunity acquired after splenectomy has not been determined.
Veronica Bordoni, Bianca Laura Cinicola, Eva Piano Mortari, Concetta Castilletti, Federica Guarracino, Christian Albano, Silvia Accordini, Anwar Baban, Antonio Di Sabatino, Carlo Maria Rossi, Marco Vincenzo Lenti, Anna Maria Zicari, Riccardo Cirelli, Marco Spada, Gian Luca Forni, Isabella Quinti, Mattia Algeri, Maddalena Casale, Silverio Perrotta, Franco Locatelli, Chiara Agrati, Rita Carsetti   +21 more
wiley   +1 more source

Aged AG129 mice support the generation of highly virulent novel mouse-adapted DENV (1-4) viruses exhibiting neuropathogenesis and high lethality

Virus Research
Dengue virus infection in humans ranges from asymptomatic infection to severe infection, with ∼2.5 % overall disease fatality rate. Evidence of neurological manifestations is seen in the severe form of the disease, which might be due to the direct ...
Gazala Siddqui, Preeti Vishwakarma, Shikha Saxena, Varun Kumar, Sneh Bajpai, Amit Kumar, Satish Kumar, Ritika Khatri, Jaskaran Kaur, Sankar Bhattacharya, Shubbir Ahmed, Gulam Hussain Syed, Yashwant Kumar, Sweety Samal   +13 more
doaj  

Quadrivalent cell culture influenza virus vaccine. Comparison to egg-derived vaccine

Human Vaccines & Immunotherapeutics, 2020
Influenza virus infections pose a serious public health problem and vaccination is the most effective public health intervention against them. The current manufacture of influenza vaccines in embryonated chicken eggs entails significant limitations ...
Alberto Pérez-Rubio, Julio Ancochea, Jose María Eiros Bouza   +2 more
doaj   +1 more source

A Novel Sequence-Based Antigenic Distance Measure for H1N1, with Application to Vaccine Effectiveness and the Selection of Vaccine Strains [PDF]

Protein Engineering, Design & Selection 24 (2011) 291-299, 2012
H1N1 influenza causes substantial seasonal illness and was the subtype of the 2009 influenza pandemic. Precise measures of antigenic distance between the vaccine and circulating virus strains help researchers design influenza vaccines with high vaccine effectiveness.
arxiv  

TIV vaccination modulates host responses to influenza virus infection that correlate with protection against bacterial superinfection [PDF]

, 2019
Background: Influenza virus infection predisposes to secondary bacterial pneumonia. Currently licensed influenza vaccines aim at the induction of neutralizing antibodies and are less effective if the induction of neutralizing antibodies is low and/or the
Choi, Angela, Christopoulou, Ioanna, García-Sastre, Adolfo, Saelens, Xavier, Schotsaert, Michael   +4 more
core   +2 more sources

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Advanced NanoBiomed Research, EarlyView.
Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska, Andre G. Skirtach, Anna M. Kaczmarek   +2 more
wiley   +1 more source

Fighting flu: novel CD8+ T‐cell targets are required for future influenza vaccines

Clinical & Translational Immunology
Seasonal influenza viruses continue to cause severe medical and financial complications annually. Although there are many licenced influenza vaccines, there are billions of cases of influenza infection every year, resulting in the death of over half a ...
Samuel Liwei Leong, Stephanie Gras, Emma J Grant   +2 more
doaj   +1 more source

Pilot Study on Evaluating the Impact of Tetanus, Diphtheria, and Pertussis (Tdap), Influenza, and COVID-19 Vaccinations on Antibody Responses in Pregnant Women

Vaccines
This study assessed IgG levels to influenza/pertussis and neutralizing antibody (Nab) responses of COVID-19 vaccines in blood of pregnant women following immunization with pertussis (Tdap), influenza, and COVID-19 vaccines.
Wei-Chun Chen, Shu-Yu Hu, Chao-Min Cheng, Ching-Fen Shen, Hui-Yu Chuang, Chin-Ru Ker, Der-Ji Sun, Ching-Ju Shen   +7 more
doaj   +1 more source

Influenza vaccines and immunopathology [PDF]

Expert Review of Vaccines, 2012
“…the concern over immunopathology resulting from T-cell responses to nucleoprotein or other conserved antigens in the absence of neutralizing antibodies in humans can be narrowed to high-dose infections with some pandemic viruses, although both in 1918 and 2009, there is evidence that T-cell responses were more likely to be responsible for protection ...
openaire   +3 more sources