Results 21 to 30 of about 968,734 (398)

Influenza vaccines: Past, present, and future

Reviews in Medical Virology, 2021
Globally, infection by seasonal influenza viruses causes 3–5 million cases of severe illness and 290,000–650,000 respiratory deaths each year. Various influenza vaccines, including inactivated split‐ and subunit‐type, recombinant and live attenuated ...
Y. Kim, Kee-Jong Hong, Hun Kim, J. Nam
semanticscholar   +1 more source

DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8+ T Cell Responses, Enabling Faster Resolution of Influenza Disease [PDF]

, 2016
Current influenza vaccines are effective but imperfect, failing to cover against emerging strains of virus and requiring seasonal administration to protect against new strains. A key step to improving influenza vaccines is to improve our understanding of
Bogen, B, Brunsvik Frediksen, A, Grodeland, G, Kinnear, E, Lambert, L, Lindberg, MM, Mcdonald, JU, Stubsrud, E, Tregoning, JS   +8 more
core   +7 more sources

A DNA Vaccine That Encodes an Antigen-Presenting Cell-Specific Heterodimeric Protein Protects against Cancer and Influenza

Molecular Therapy: Methods & Clinical Development, 2020
Immunogenicity of DNA vaccines can be increased by constructing the DNA in such a way that it encodes secreted homodimeric fusion proteins that target antigen-presenting cells (APCs). In this study, we have developed novel APC-targeting vaccine molecules
Ranveig Braathen, Heidi Cecilie Larsen Spång, Daniëla Maria Hinke, Jana Blazevski, Sonja Bobic, Even Fossum, Bjarne Bogen   +6 more
doaj   +1 more source

M2e-Based Influenza Vaccines with Nucleoprotein: A Review

Vaccines, 2021
Discovery of conserved antigens for universal influenza vaccines warrants solutions to a number of concerns pertinent to the currently licensed influenza vaccines, such as annual reformulation and mismatching with the circulating subtypes.
M. Tan, W. Tan, Noorjahan Banu Mohamed Alitheen, W. Yap   +3 more
semanticscholar   +1 more source

Solid bioneedle-delivered influenza vaccines are highly thermostable and induce both humoral and cellular immune responses. [PDF]

PLoS ONE, 2014
The potential of bioneedles to deliver influenza vaccines was investigated. Four influenza vaccine formulations were screened to determine the optimal formulation for use with bioneedles.
Peter C Soema, Geert-Jan Willems, Klaas van Twillert, Gijsbert van de Wijdeven, Claire J Boog, Gideon F A Kersten, Jean-Pierre Amorij   +6 more
doaj   +1 more source

Haemagglutination inhibition and virus microneutralisation serology assays: use of harmonised protocols and biological standards in seasonal influenza serology testing and their impact on inter-laboratory variation and assay correlation: A FLUCOP collaborative study

Frontiers in Immunology, 2023
IntroductionThe haemagglutination inhibition assay (HAI) and the virus microneutralisation assay (MN) are long-established methods for quantifying antibodies against influenza viruses. Despite their widespread use, both assays require standardisation to
Joanna Waldock, Edmond J. Remarque, Lingyi Zheng, Sammy Ho, Katja Hoschler, Britta Neumann, Hanna Sediri-Schön, Claudia M. Trombetta, Emanuele Montomoli, Serena Marchi, Giulia Lapini, Fan Zhou, Sarah L. Lartey, Rebecca J. Cox, Marzia Facchini, Maria Rita Castrucci, Damien Friel, Thierry Ollinger, Catherine Caillet, Nedzad Music, Giuseppe Palladino, Othmar G. Engelhardt, the FLUCOP consortium   +22 more
doaj   +1 more source

Influenza Vaccines: Successes and Continuing Challenges

Journal of Infectious Diseases, 2021
Influenza vaccines have been available for over 80 years. They have contributed to significant reductions in influenza morbidity and mortality. However, there have been limitations in their effectiveness, in part due to the continuous antigenic evolution
T. Becker, Husni Elbahesh, L. Reperant, G. Rimmelzwaan, A. Osterhaus   +4 more
semanticscholar   +1 more source

Comparative safety of mRNA COVID‐19 vaccines to influenza vaccines: A pharmacovigilance analysis using WHO international database

Journal of Medical Virology, 2021
Two messenger RNA (mRNA) vaccines developed by Pfizer‐BioNTech and Moderna are being rolled out. Despite the high volume of emerging evidence regarding adverse events (AEs) associated with the COVID‐19 mRNA vaccines, previous studies have thus far been ...
Min Seo Kim, S. Jung, Jong Gyun Ahn, Se Jin Park, Y. Shoenfeld, A. Kronbichler, A. Koyanagi, E. Dragioti, K. Tizaoui, Sung Hwi Hong, L. Jacob, J. Salem, D. Yon, Seung Won Lee, S. Ogino, Hanna Kim, Jerome H. Kim, J. Excler, F. Marks, J. Clemens, M. Eisenhut, Y. Barnett, L. Butler, C. Ilie, E. Shin, Jae Il Shin, Lee Smith   +26 more
semanticscholar   +1 more source

An Overview of Influenza Viruses and Vaccines

Vaccines, 2021
Influenza remains one of the major public health concerns because it causes annual epidemics and can potentially instigate a global pandemic. Numerous countermeasures, including vaccines and antiviral treatments, are in use against seasonal influenza ...
R. Nuwarda, A. Alharbi, Veysel Kayser
semanticscholar   +1 more source

Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir [PDF]

, 2014
Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza ...
Barclay, Wendy S., Bean, Thomas J., Bruce, Christine, Carroll, Miles W., Dimmock, N. J., Dove, Brian K., Dowall, Stuart, Easton, A. J. (Andrew J.), Hallis, Bassam, Marriott, Anthony C., Newman, Edmund, Pearson, Geoff, Plank, Jenna, Rayner, Emma, Ryan, Kathryn A., Silman, Nigel J., Taylor, Irene, Whittaker, Catherine J.   +17 more
core   +9 more sources