Results 71 to 80 of about 109,024 (308)

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, EarlyView.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source

Enhanced isolation of influenza viruses in qualified cells improves the probability of well-matched vaccines

npj Vaccines, 2021
Influenza vaccines are utilised to combat seasonal and pandemic influenza. The key to influenza vaccination currently is the availability of candidate vaccine viruses (CVVs).
Heidi Peck, Karen L. Laurie, Steve Rockman, Vivian Leung, Hilda Lau, Sally Soppe, Cleve Rynehart, Chantal Baas, Heidi Trusheim, Ian G. Barr   +9 more
doaj   +1 more source

Advances in Adjuvanted Influenza Vaccines

Vaccines, 2023
The numerous influenza infections that occur every year present a major public health problem. Influenza vaccines are important for the prevention of the disease; however, their effectiveness against infection can be suboptimal.
Shintaro Shichinohe, Tokiko Watanabe
doaj   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Influenza vaccination in the elderly [PDF]

Human Vaccines & Immunotherapeutics, 2017
Seasonal influenza is a prevalent and serious annual illness resulting in widespread morbidity and economic disruption throughout the population; the elderly and immunocompromised are particularly vulnerable to serious sequelae and mortality. The changing demographics worldwide to an aging society have important implications for public health policy ...
Jan Smetana, Roman Chlibek, Jana Shaw, Miroslav Splino, Roman Prymula   +4 more
openaire   +4 more sources

Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions

Advanced Healthcare Materials, EarlyView.
A multi‐scale, hierarchical ‘Safety‐by‐Design’ pipeline combining machine learning, ex vivo human blood assays, and in vivo models enables the systematic immunotoxicity and biocompatibility profiling of nanoscale metal‐organic frameworks, accelerating their safe clinical translation. Abstract The clinical translation of metal‐organic frameworks (MOFs) –
Yunhui Zhuang, Bárbara B. Mendes, Dhruv Menon, Jhenifer Oliveira, Xu Chen, Fatma Demir Duman, João Conniot, Sergio Mercado, Xiewen Liu, Shi‐Yuan Zhang, João Conde, Rachel E. Hewitt, David Fairen‐Jimenez   +12 more
wiley   +1 more source

Automated Label‐Free Assay for Viral Detection and Inhibitor Screening via Biomembrane‐Functionalized Microelectrode Arrays

Advanced Materials, EarlyView.
A bioelectronic sensor integrating 2D cell membranes with organic microelectrode arrays enables detection of SARS‐CoV‐2 fusion pathways. Natively‐expressed viral receptors promote monitoring of viral entry and screening of antibody‐based inhibitors.
Zixuan Lu, Jeremy Treiber, Konstantinos Kallitsis, Ekaterina Selivanovitch, Alexandra Wheeler, Maria Lopez‐Cavestany, Zhongmou Chao, Sarah L Barron, Ju An Park, Darius Hoven, Anna Scheeder, Aimee Withers, Becky M. Hess, Clemens F. Kaminski, Alberto Salleo, Anna‐Maria Pappa, Susan Daniel, Róisín M Owens   +17 more
wiley   +1 more source

An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged mice

Human Vaccines & Immunotherapeutics
Currently, vaccination with influenza vaccines is still an effective strategy to prevent infection by seasonal influenza virus. However, seasonal influenza vaccines frequently fail to induce effective immune protection against rapidly changing seasonal ...
Liang Xu, Zhihao Yu, Yifan Xu, Qin Wang, Guiqin Wang, Benchi Li, Qian Weng, Yongxiang Yi, Junwei Li   +8 more
doaj   +1 more source

Bacterially produced recombinant influenza vaccines based on virus-like particles. [PDF]

PLoS ONE, 2013
Although current influenza vaccines are effective in general, there is an urgent need for the development of new technologies to improve vaccine production timelines, capacities and immunogenicity.
Andrea Jegerlehner, Franziska Zabel, Alice Langer, Klaus Dietmeier, Gary T Jennings, Philippe Saudan, Martin F Bachmann   +6 more
doaj   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source