Results 51 to 60 of about 2,123,414 (312)

Propagation of Rhinovirus C in Differentiated Immortalized Human Airway HBEC3-KT Epithelial Cells

Viruses, 2019
Rhinoviruses (RVs) are classified into three species: RV-A, B, and C. Unlike RV-A and -B, RV-C cannot be propagated using standard cell culture systems. In order to isolate RV-Cs from clinical specimens and gain a better understanding of their biological
Mina Nakauchi, Noriyo Nagata, Ikuyo Takayama, Shinji Saito, Hideyuki Kubo, Atsushi Kaida, Kunihiro Oba, Takato Odagiri, Tsutomu Kageyama   +8 more
doaj   +1 more source

Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways

Nature Communications, 2022
The SARS-CoV-2 variant of concern Omicron, has been reported to mainly use the endocytosis pathway for viral entry, bypassing the furin/TMPRSS2 pathway utilised by other variants. Here, the authors test a panel of SARS-CoV-2 variants in TMPRSS2 knock out
Naoko Iwata-Yoshikawa, Masatoshi Kakizaki, Nozomi Shiwa-Sudo, Takashi Okura, Maino Tahara, Shuetsu Fukushi, Ken Maeda, Miyuki Kawase, Hideki Asanuma, Yuriko Tomita, Ikuyo Takayama, Shutoku Matsuyama, Kazuya Shirato, Tadaki Suzuki, Noriyo Nagata, Makoto Takeda   +15 more
doaj   +1 more source

First detection of SARS-CoV-2 variant B.1.1.529 (Omicron) in Ecuador

New Microbes and New Infections, 2022
The National Institute of Research and Public Health reported the first local record of the Omicron variant detected in Ecuador. A fully vaccinated subject returned from South Africa with a negative RT-PCR.
A. Carrazco-Montalvo, I. Armendáriz-Castillo, C.L. Tello, D. Morales, R. Armas-Gonzalez, D. Guizado-Herrera, A. León-Sosa, D. Ramos-Sarmiento, B. Fuertes, L. Patino, P. Cárdenas, S. Márquez, B. Prado-Vivar, J.J. Guadalupe, B. Gutiérrez, M.B. Wong, M. Grunauer, G. Trueba, P. Rojas-Silva, V. Barragán   +19 more
doaj   +1 more source

Metagenomic Nanopore Sequencing of Influenza Virus Direct from Clinical Respiratory Samples

Journal of Clinical Microbiology, 2019
Influenza is a major global public health threat as a result of its highly pathogenic variants, large zoonotic reservoir, and pandemic potential. Metagenomic viral sequencing offers the potential for a diagnostic test for influenza virus which also ...
Kuiama Lewandowski, Yifei Xu, S. Pullan, S. Lumley, D. Foster, N. Sanderson, A. Vaughan, M. Morgan, Nicole Bright, J. Kavanagh, R. Vipond, M. Carroll, A. Marriott, K. Gooch, M. Andersson, K. Jeffery, T. Peto, D. Crook, A. Walker, P. Matthews, P. Matthews   +20 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

Nature Communications
The current model is that the influenza virus polymerase (FluPol) binds either to host RNA polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its conformation and activity towards transcription or replication of the ...
Tim Krischuns, Benoît Arragain, Catherine Isel, Sylvain Paisant, Matthias Budt, Thorsten Wolff, Stephen Cusack, Nadia Naffakh   +7 more
doaj   +1 more source

Newcastle disease virus in Egyptian domestic poultry, 2019–2021: Molecular characterization, phylogenetic analysis, and coinfection with avian influenza A virus

Open Veterinary Journal
Background: Newcastle Disease Virus (NDV) is a major viral disease of poultry that causes outbreaks in chickens in Egypt. Aim: The aim of this study was to determine the prevalence and molecular characteristics of NDV and its cocirculation with avian
Ahmed El Taweel, Mohamed El Sayes, Asmaa Maatouq, Mokhtar Gomaa, Yassmin Moatasim, Omnia Kutkat, Pamela P. McKenzie, Ahmed Kandeil, Richard J. Webby, Mohamed Ahmed Ali, Ghazi Kayali, Rabeh El-Shesheny   +11 more
doaj   +1 more source

Influenza virus polymerase inhibitors in clinical development

Current Opinion in Infectious Diseases, 2019
Purpose of review We review antivirals inhibiting subunits of the influenza polymerase complex that are advancing in clinical development. Recent findings Favipiravir, pimodivir, and baloxavir are inhibitory in preclinical models for influenza A viruses,
F. Hayden, N. Shindo
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Detection of Influenza and Other Respiratory Pathogens by RT-qPCR and Characterization by Genomic Sequencing Using ILI/SARI Hospital-Based Sentinel Surveillance System

Viruses
Limited surveillance and laboratory testing for non-influenza viruses remains a challenge in Uganda. The World Health Organization (WHO) designated National Influenza Center (NIC) tested samples from patients with influenza-like illness (ILI) and severe ...
Charity A. Nassuna, Fahim Yiga, Joweria Nakaseegu, Esther Amwine, Bridget Nakamoga, Noel Ayuro, Nicholas Owor, David Odongo, Jocelyn Kiconco, Thomas Nsibambi, Samuel Wasike, Ben Andagalu, Chelsea Harrington, Adam W. Crawley, Julius Ssempiira, Ray Ransom, Amy L. Boore, Barnabas Bakamutumaho, John T. Kayiwa, Julius J. Lutwama   +19 more
doaj   +1 more source