Results 111 to 120 of about 5,045,493 (316)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Enabling the information commons

, 2004
As more libraries embrace the term 'information commons' to name services and symbolise their mission, this paper explores the meaning of the concept in Australia and the US.
Bradley, Fiona
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Device-compatible ultra-high-order quantum noise stream cipher based on delta-sigma modulator and optical chaos

Communications Engineering
Data security is a key feature of future communications networks. Physical layer introduces rich physical mechanisms to increase the complexity of deciphering and provides extensive protection, but faces challenges in compatibility with commercial ...
Hanwen Luo, Ziheng Zhang, Longquan Dai, Linsheng Zhong, Qi Yang, Lei Deng, Deming Liu, Xiaoxiao Dai, Xiaojing Gao, Mengfan Cheng   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Application to Access Information

, 2012
Application to access ...
Information and Privacy
core  

Empfehlungen der Ad-hoc-AG Open-Access-Gold im Rahmen der Schwerpunktinitiative „Digitale Information“ der Allianz der deutschen Wissenschaftsorganisationen

, 2016
Die vorliegenden „Empfehlungen zur Open-Access-Transformation“ wurden von der Ad-hoc-Arbeitsgruppe „Open-Access-Gold“ im Rahmen der Schwerpunktinitiative „Digitale Information“ der Allianz der deutschen Wissenschaftsorganisationen erarbeitet und basieren
Hanig, Kristina, Geschuhn, Kai, Schäffler, Hildegard, Scholze, Frank, Timm, Arnulf, Ad-hoc-Arbeitsgruppe Open-Access-Gold der Schwerpunktinitiative „Digitale Information“ der Allianz der deutschen Wissenschaftsorganisationen, Pampel, Heinz, Bruch, Christoph, Hillenkötter, Kristine, Scheiner, Annette, Stanek, Ursula, Tullney, Marco   +11 more
core   +1 more source

Real-Time Path-Recovery Method for Open-Fiber-Cross-Connect-Based Networks

IEEE Access
Cloud computing with direct optical paths utilizing fiber cross connects is a promising way to realize low-latency high-reliability applications cost effectively.
Hiroshi Ou, Ayako Iwaki, Tomoya Hatano, Tatsuya Shimada, Kenichi Nakura   +4 more
doaj   +1 more source