Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Providing Secure Access to Confidential Patient Information Detailing Diabetic Condition [PDF]
, 2001 Can secure access be granted to confidential patient records using the Internet? Our study has involved providing distributed access to one such confidential information database in a United Kingdom (UK) secondary care (hospital) organisation.
McDowell, D.M. +3 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Pattern Reduction for Low-Traffic Speculative Video Transmission in Cloud Gaming System
IEEE AccessCloud gaming allows users to play high-quality games on low-end devices by offloading game processing to the cloud. However, network latency remains a significant issue affecting the gaming experience.
Takumasa Ishioka +6 more
doaj +1 more source
Disparate impacts on online information access during the Covid-19 pandemic. [PDF]
Nat Commun, 2022 Suh J, Horvitz E, White RW, Althoff T.
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Adaptive decentralized AI scheme for signal recognition of distributed sensor systems
Opto-Electronic AdvancesArtificial intelligence (AI) plays a critical role in signal recognition of distributed sensor systems (DSS), boosting its applications in multiple monitoring fields. Due to the domain differences between massive sensors in signal acquisition conditions,
Shixiong Zhang +8 more
doaj +1 more source
Enhance Software-Defined Network Security with IoT for Strengthen the Encryption of Information Access Control. [PDF]
Comput Intell Neurosci, 2022 Vimal V +6 more
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Rural small scale farmers' smart mobile phone usage acceptance prognosticators for agricultural marketing information access. [PDF]
SN Soc Sci, 2022 Nyagadza B +5 more
europepmc +1 more source