Results 81 to 90 of about 2,539,971 (262)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Artequakt: Generating tailored biographies from automatically annotated fragments from the web [PDF]
, 2002 The Artequakt project seeks to automatically generate narrativebiographies of artists from knowledge that has been extracted from the Web and maintained in a knowledge base.
Alani, Harith +6 more
core
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
An Ostensive Information Architecture to Enhance Semantic Interoperability for Healthcare Information Systems. [PDF]
Inf Syst Front, 2023 Guo H, Scriney M, Liu K.
europepmc +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Information Architecture / Enformasyon Mimarisi [PDF]
Bilgi Dünyası, 2004 For some time now, the pundits have been declaiming that “Information is the fourth resource”, and that to ignore that fact will inevitably lead to organisational catastrophe.
Alan Gilchrist
doaj
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Architectures of Information [PDF]
Études de communication, 2013 L’article soutient que, dans le cadre du passage du paradigme postmoderniste au paradigme pseudo-moderniste, l’environnement technologique, economique, social et culturel a profondement modifie l’architecture de l’information depuis les annees 1990.
openaire +2 more sources
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Metadados de negócio: representação da informação dos processos de trabalho
Transinformação, 2019 Resumo Metadados são considerados elementos fundamentais na Ciência da Informação e suas características, aplicações e tipologias vêm sendo bastante estudados pelos pesquisadores da área, principalmente a partir dos anos 2000.
Mariana Baptista BRANDT +1 more
doaj +1 more source