Results 121 to 130 of about 18,276,657 (278)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Information Research: An International Electronic JournalIntroduction. This paper examines academics’ information behaviour in undertaking research for societal impact. It explores how researcher-stakeholder relationships provide sites of information exchange where academics develop skills and knowledge needed
Joann Cattlin, Lisa M. Given
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Recent trends in user studies: action research and qualitative methods
Information Research: An International Electronic Journal, 1998 This paper was commissioned by Professor Gernot Wersig of the Freie Universität, Berlin in 1980, as part of his Project, Methodeninstrumentarium zur Benutzforschung in Information und Dokumentation.
T.D. Wilson
doaj
Information Need and Information Seeking Behaviour
Türk Kütüphaneciliği, 1997 Information need is one of the cognitive needs of humankind. Information need causes information seeking behaviour and these concepts complement each other. Information need and information seeking behaviour are effected by many factors. It is necessary to know these factors in establishing the effective information centers and services.
openaire +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Agentic behaviours are often characterised as actions that revolve around being assertive and achievement-oriented, whereas communal behaviours are centered on cooperation, empathy, and promoting social harmony.
Zhang, Xue, Goh, Zhang Hao
core +1 more source
Health information-seeking among Latino newcomers - an exploratory study
Information Research: An International Electronic Journal, 2005 ntroduction. This exploratory study examines health information-seeking practices among Latin American newcomers to a small city in the United States. The framework locates these practices within social networks, the local institutional context and the ...
Christina Courtright
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Introduction to information behaviour
, 2015 This landmark textbook is an essential primer for students and practitioners interested in information seeking, needs and behaviour, user studies and information ...
Ford, Nigel
core