Results 111 to 120 of about 689,793 (290)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Trends in information behaviour research.

open access: yesInf. Res., 2014
Introduction. This paper traces current trends in information behaviour research, both in terms of methods and topics. Results are put into relation to the previous trend analysis by Julien et al. (2011) and Vakkari (2008).Method. Trends derive from a publication analysis taken from information behaviour related publication venues between 2012 and 2014.
openaire   +2 more sources

Mobile Information Literacy: a preliminary outline of information behaviour in a mobile environment

open access: yes, 2012
The purpose of this paper is to examine the idea that information searching and use may vary with the widespread use of internet capable movile devices.
Walsh, Andrew
core  

Multitasking information behaviour in public libraries : a survey study

open access: yes, 2007
Multitasking information behaviour is the human ability to handle the demands of multiple information tasks concurrently. When we multitask, we work on two or more tasks and switch between those tasks.
Narayan, Bhuva   +4 more
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Information seeking behaviour models in Information Retrieval

open access: yes
Information retrieval study can broadly be categorized into two portions; System centered research that centers on the systems perspectives of information retrieval counting retrieval algorithms, indexing, interface design, etc, and user-centered research that centers on the human information behavior and user-centered or cognitive approaches to the ...
openaire   +2 more sources

Examining Group Process through an Information Behaviour Lens: How Student Groups Work with Information to Accomplish Tasks

open access: yes, 2014
Organizations increasingly rely on groups of knowledge workers to make decisions, design products, manage projects, and develop strategy. Information is central to group task accomplishment.
Toze, Sandra L.
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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