Results 81 to 90 of about 19,190,977 (299)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Predictive information in Gaussian processes with application to music analysis [PDF]
, 2013 This is the author's accepted manuscript of this article. The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-40020-9.Lecture Notes in Computer ScienceLecture Notes in Computer ScienceWe describe an information ...
Geometric Science of Information +2 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Information-making-related information needs and the credibility of information
, 2020 Introduction. Even if trust in the process of how information is made has been acknowledged as a key aspect of the credibility of information, there is little earlier research on how and if people use or want information on information making when doing ...
Huvila, Isto, Huvila, Isto,, Isto Huvila
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
EntropyFunctional near-infrared spectroscopy (fNIRS) is a non-invasive imaging technique that measures brain hemodynamic activity by detecting changes in oxyhemoglobin and deoxyhemoglobin concentrations using light in the near-infrared spectrum. This study aims
Irene Franzone +6 more
doaj +1 more source
Will the Semantic Web Change Education?
Journal of Interactive Media in Education, 2004 : To say that the Web has affected many societies and cultures is to understate its impact along several dimensions. The Web is a technology which not only affects, but in some sense encompasses societies, cultures, and certainly institutions.
Kendall Clark +2 more
doaj +1 more source
General Dynamics Corporation Report GA-1612
, 1960 From preface: This report presents the status of design of the MGCR prototype plant as of July 1 ...
General Dynamics Corporation
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
pSpatiocyte: a high-performance simulator for intracellular reaction-diffusion systems
BMC Bioinformatics, 2020 Background Studies using quantitative experimental methods have shown that intracellular spatial distribution of molecules plays a central role in many cellular systems.
Satya N.V. Arjunan +3 more
doaj +1 more source