Results 111 to 120 of about 17,455,412 (293)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Unsupervised and interpretable track‐to‐track association based on homography estimation of radar bias

IET Radar, Sonar & Navigation
Track‐to‐track association methods based on machine learning and deep learning have greatly improved the association results, but the scope of application is limited by the poor interpretability and manual association labelling.
Xiong Wei, Xu Pingliang, Cui Yaqi
doaj   +1 more source

A Small Maritime Target Detection Method Using Nonlinear Dimensionality Reduction and Feature Sample Distance

Remote Sensing
Addressing the challenge of radar detection of small targets under sea clutter, target detection methods based on a three-dimensional feature space have shown effectiveness.
Jian Guan, Xingyu Jiang, Ningbo Liu, Hao Ding, Yunlong Dong, Zhongping Guo   +5 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

CIAG: Conditional Idempotent Association Generation for Heterogeneous Track‐to‐Track Association

IET Radar, Sonar & Navigation
In advanced defence and security systems, multi‐sensor fusion is widely used to improve the overall observation capability, and heterogeneous sensors are a typical deployment in multi‐sensor systems.
Pingliang Xu, Yaqi Cui, Wei Xiong
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Publisher Correction: Initial analytical theory of plasma disruption and experimental evidence

Scientific Reports, 2023
Huibin Qiu, Zuozhi Hu, Shengfa Wu, Jiangcun Chen, Chengjie Zhong, Junjie Wu, Xiaobin Li, Donghua Xiao, Chunhui Shi, Junhui Liu, Wenjun Xiong, Tianyi Hu, Qilong Cai, Youlong Yuan   +13 more
doaj   +1 more source

Explainable Recognition of Complex Flight Maneuvers via Retrieval-Augmented Large Language Models

Entropy
Complex flight maneuver recognition (FMR) underpins intelligent flight training, including training assessment, pilot skill profiling, and flight safety monitoring.
Liqiang Ren, Haipeng Wang, Xinlong Pan, Tiantian Tang, Hongdong Wan   +4 more
doaj   +1 more source