Results 91 to 100 of about 17,455,412 (293)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Implications of a Weickian perspective on decision making for information fusion research and practice

, 2007
The purpose of information fusion is to support and improve decision making. However, theories of decision making differ significantly on their view of what a good decision actually is. Hence, depending on which decision making theory one (un)consciously
Nilsson, Maria,, Tom Ziemke, Maria Nilsson, van Laere, Joeri,, Ziemke, Tom,, Joeri van Laere   +5 more
core   +1 more source

How certain is certain? Evaluation of uncertainty in the fusion of information derived from diverse sources

, 2022
S.1613-1620Todays asymmetric military operations, often involve multiple partners, including the armed forces of allied nations, relief agencies and other organizations.
Schade, U., Rein, K.
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison of tracklet fusion and distributed Kalman filter for track fusion

, 2022
8 S.In track fusion, the measurements of individual sensors for each target are processed to generate local state estimates, which are then fused to obtain the global state estimate for the target. When there is no process noise or the fusion rate equals
Chong, C.-Y., Govaers, F., Mori, S., Koch, W.   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Small target detection of floating objects in river channels based on improved YOLOv7

Scientific Reports
Computer vision-aided small target detection in moving streams, such as rivers/ roads, requires a fast-converging outcome as the frame requirements are high.
Weifeng Yang, Bing Zhang, Su Guo, Kebin Gao, Jianwei Ying, Jun Zheng, Chao Li, Jun Li, Weigang Xu, Qi Chen, Jun Cao, Youxiang Zuo, Yu Chen, Wenjie Wang   +13 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Multi-level fusion of hard and soft information [PDF]

, 2014
Proceedings of: 17th International Conference on Information Fusion (FUSION 2014): Salamanca, Spain 7-10 July 2014.Driven by the underlying need for a yet to be developed framework for fusing heterogeneous data and information at different semantic ...
Snidaro, Lauro, V. Nimier, Biermann, Joaquim, J. Garcia, K. Rein, Nimier, Vincent, Rein, Kellyn, Krenc, Ksawery, J. Biermann, K. Krenc, García, Jesús   +10 more
core   +1 more source