Results 71 to 80 of about 17,455,412 (293)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 2021 © 2019 ISIF-International Society of Information Fusion. The problem of distributed information (data) fusion is considered in this paper. Using a new class of functionals to perform data fusion-the power mean-information fusion can be performed in a ...
Bishop, AN, Taylor, CN
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Integration of soft data for information fusion: Pitfalls, challenges and trends
, 2022 8 S.This paper explores the question of soft data integration for information fusion. The topic is of particular interest in military and civilian fusion applications making use of both sensor and human-based information.
Dragos, V., Rein, K.
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Information fusion in practice: A distributed cognition perspective on the active role of users
, 2012 Traditionally, the focus of most information fusion research has been on computational aspects, as illustrated by, for example, different versions of the JDL data fusion model.
Susi, Tarja, +7 more
core +1 more source
International Journal of Distributed Sensor Networks, 2019 To handle nonlinear filtering problems with networked sensors in a distributed manner, a novel distributed hybrid consensus–based square-root cubature quadrature information filter is proposed.
Jun Liu +5 more
doaj +1 more source
IEEE Access, 2020 Conductor galloping seriously threatens the safe operation of power systems and may lead to various damages such as wire fractures or tower collapses and large-scale grid breakdowns.
Decheng Wu +3 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source