Results 41 to 50 of about 438,838 (312)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Considerations Regarding Theoretical Foundations of Information Infrastructure and Economic Growth [PDF]

open access: yesRevista de Management Comparat International
This paper provides an in-depth theoretical analysis of the fundamentals of information infrastructure and its relationship to economic growth and development.
Xiaoliang ZHANG   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The Level of Cybersecurity of the BRICS Member Countries in International Ratings: Prospects for Cooperation

open access: yesBRICS Law Journal, 2023
Creating a legal framework for cybersecurity is a key factor in the digitalization of an economy. The interaction between the BRICS member countries has undergone a digital transformation, which has improved their ability to work together economically ...
O. Ovchinnikova, N. K. Upadhyay
doaj   +1 more source

Global Information Infrastructure

open access: yes, 2006
Identify the major components of the global information infrastructure. Ö Begin to understand how communication network technologies are bringing the world closer together. Ö Come to understand the growing dependence that societies and businesses have on
Andrew Colarik
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

„WEITER WISSEN. Mit uns.“ Ein Bericht über die Kampagne der wissenschaftlichen Bibliotheken

open access: yesGMS Medizin – Bibliothek – Information
Academic libraries play a central role as a driving force for open science and society. They provide researchers, academics and students with access to information and promote media literacy.
Ostrzinski, Ulrike
doaj   +1 more source

A procedure for evaluating the influence of road context on drivers’ visual behaviour

open access: yesTransport, 2016
In this paper, we investigated drivers’ visual behaviour while travelling a road regularly opened to traffic in order to evaluate the effectiveness of the traditional scientific models and propose, at the same time, further measures useful for ...
Nicola Bongiorno   +2 more
doaj   +1 more source

THE NATIONAL 3-D GEOSPATIAL INFORMATION WEB-BASED SERVICE OF KOREA [PDF]

open access: yesISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2013
3D geospatial information systems should provide efficient spatial analysis tools and able to use all capabilities of the third dimension, and a visualization.
D. T. Lee, C. W. Kim, I. G. Kang
doaj   +1 more source

A Reference Model for Information Infrastructures [PDF]

open access: yes, 1999
There are a number of different approaches to information infrastructures, all of which purport to be an answer to the problem of integrating diverse heterogeneous systems. Frameworks and Reference Models are also used for similar purposes. Each has a slightly different focus and approach, yet all are essentially addressing the same problem.
Ramez Elmasri   +3 more
openaire   +1 more source

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