Results 61 to 70 of about 1,048,956 (299)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Designing Edutainment Games for Intangible Cultural Heritage: the BNREG Project
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2019 This paper presents the preliminary investigation and game design process of Beijing Nursery Rhyme Edutainment Game (hereinafter referred to as BNREG), from which we think edutainment concept can provide an innovative gamification method for the impart ...
Xiaoshuang Jia +4 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2019 On the basis of the historical classics of Guangxu emperor’s wedding held in the Forbidden City, we build a website to preserve and reappear Guangxu Emperor’s wedding, with the purpose of promoting the rite and the royal wedding culture of Qing dynasty.
Jihong Liang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Digital Inheritance of POPF Based on Image Database and Identification Model
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2019 Pecking Opera Painted Faces (POPF) is a Chinese intangible cultural heritage full of aesthetic value. However, their cultural connotations become less known in modern society.
Guancan Yang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Вестник университета, 2017 In the article, authors considered value of information resource as bases of high-quality comparison of public-private partnership at development of transport infrastructure at different social and economic stages of development of Russia.
T. Bogdanova
doaj
Using Digital Storytelling in a Virtual 3D-Museum for Beijing Old Objects
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2019 This paper presents an overview of the construction of a virtual online 3D-museum for Beijing old objects (3D-BOOM) through digital storytelling. The project of 3D-BOOM proposed, implemented and evaluated an innovative conceptual and technological ...
Yanyan Wang +4 more
doaj +1 more source