Results 61 to 70 of about 10,118,950 (292)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Users' Perceived Difficulties and Corresponding Reformulation Strategies in Google Voice Search [PDF]

Journal of Library and Information Studies, 2016
In this article, we report users’ perceptions of query input errors and query reformulation strategies in voice search using data collected through a laboratory user study.
Wei Jeng, Jiepu Jiang, Daqing He
doaj   +1 more source

Wikiformer: Pre-training with Structured Information of Wikipedia for Ad-hoc Retrieval [PDF]

, 2023
Weihang Su, Qingyao Ai, Xiangsheng Li, Jia Chen, Yiqun Liu, Xiaolong Wu, Shengluan Hou   +6 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

An ECC with error detection and against side channel attacks for resource constrained devices

Journal of King Saud University: Computer and Information Sciences
As more devices are integrated into the Internet of Things (IoT) ecosystem, accurate and efficient information transmission between resource-constrained equipment has become particularly important.
Jun Ye, Zewen Yang
doaj   +1 more source

Species Distribution Modelling via Feature Engineering and Machine Learning for Pelagic Fishes in the Mediterranean Sea

Applied Sciences, 2020
In this work a fish species distribution model (SDM) was developed, by merging species occurrence data with environmental layers, with the scope to produce high resolution habitability maps for the whole Mediterranean Sea.
Dimitrios Effrosynidis, Athanassios Tsikliras, Avi Arampatzis, Georgios Sylaios   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Explainable self-supervised learning for medical image diagnosis based on DINO V2 model and semantic search

Scientific Reports
Medical images have become indispensable for decision-making and significantly affect treatment planning. However, increasing medical imaging has widened the gap between medical images and available radiologists, leading to delays and diagnosis errors ...
Alaa Hussien, Abdelkareem Elkhateb, Mai Saeed, Nourhan M. Elsabawy, Alaa Ebraheem Elnakeeb, Nora Elrashidy   +5 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Ethical Dimensions of Music Information Retrieval Technology

Transactions of the International Society for Music Information Retrieval, 2018
This article examines ethical dimensions of Music Information Retrieval (MIR) technology.  It uses practical ethics (especially computer ethics and engineering ethics) and socio-technical approache ...
A. Holzapfel, Bob L. Sturm, Mark Coeckelbergh   +2 more
semanticscholar   +1 more source