Results 91 to 100 of about 11,455,659 (340)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Ciência da informação: denominação de curso e diretrizes curriculares

open access: yesTransinformação
Discussão das especificidade da Ciência da informação e da Arquivologia e de suas relações interdisciplinares.
Maria Odila Fonseca
doaj  

University Library Information Resources as a Basis for Enhancing Educational and Professional Programmes in Information, Library and Archival Studies

open access: yesActa Informatica Pragensia
The article aims to explore the role of information resources provided by university libraries in strengthening educational and professional programmes in the field of Information, Library and Archival Studies based on the Scientific Library of Kyiv ...
Nadiia Bachynska   +4 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Web 2.1 : Toward a large and qualitative participation on the Web

open access: yesJournal of Information and Organizational Sciences, 2009
This article presents the results of research done on Web 2.0 within the School of Information Sciences ESI. It aims to study the behavior of different academic actors who deal with information, among whom we cite teachers, students of masters and ...
Boubker Sbihi   +2 more
doaj  

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