Results 91 to 100 of about 3,430,903 (260)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Expanding the Chemical Information Science gateway. [PDF]

F1000Res, 2021
Medina-Franco JL.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

La Documentación como ciencia integradora. Acercamiento sistemático a las unidades documentales

Anales de Documentación, 2006
Estructurado en dos partes: La Documentación como ciencia integradora y Acercamiento sistémico a las unidades documentales, este trabajo entiende la Documentación desde una perspectiva integradora traída del hermanamiento que supone el mismo modus ...
Rita Dolores Santaella Ruiz
doaj  

Impacts of covid-19 pandemic in the Brazilian research scenario on misinformation: Analysis of publications from information science journals. [PDF]

J Librariansh Inf Sci, 2022
de Assis SSD, Gerlin MNM.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Ações de pesquisa e extensão no projeto laboratório de tecnologias intelectuais

Transinformação
Este trabalho apresenta os primeiros resultados do Projeto Laboratório de Tecnologias Intelectuais, em desenvolvimento mediante parceria entre o Departamento de Ciência da Informação e o Programa de Pós-Graduação em Ciência da Informação da Universidade ...
Isa Maria Freire, Edvaldo Carvalho Aalves, Julio Afonso Sá de Pinho Neto, Marckson Ferreira de Souza   +3 more
doaj  

A scholarly network of AI research with an information science focus: Global North and Global South perspectives. [PDF]

PLoS One, 2022
Tang KY, Hsiao CH, Hwang GJ.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Knowledge Organization for Learning. Conjectures and Methods of Study

Ciência da Informação, 2015
This paper discusses and illustrates through examples how meaningful or deep learning can be supported through well-structured presentation of material, through giving learners schemas they can use to organize knowledge in their minds, and through ...
Dagobert Soergel
doaj